A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Dound, Yogesh
- Nosocomial Infections:A Challenge to the Indian Healthcare Industry
Authors
1 Bomay College of Pharmacy, IN
Source
The Indian Practitioner, Vol 69, No 7 (2016), Pagination: 28-30Abstract
Nosocomial infections (NI) also known as hospital acquired infections (HAI) are one of the major concerning issues in healthcare industry. It can result in morbidity and also mortality. Common multi-drug-resistant organisms include Vancomycin-resistant enterococci (VRE), P. aeruginosa and Klebsiella pneumonia, Methicillin-resistant S. aureus (MRSA). Safety measures can be adopted by hospital authorities to control NI's, such as hand hygiene, proper surveillance system appropriate use of antibiotics etc. This will not only reduce the prolonged Nosocomial stay and morbidity, mortality associated with NI's but also the cost for the treatment.References
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- Dr. Anand Saxena, Dr. Mahendra Pratap Singh, Dr. Swagata Brahmchari, et al., Surgical Site Infection Among Postoperative Patients Of Tertiary Care Centre In Central India - A Prospective Study, © Asian Journal of Biomedical and Pharmaceutical Sciences, all rights reserved. Volume 3, Issue 17, 2013
- Noyal Mariya Joseph, Sujatha Sistla, Tarun Kumar Dutta,et al., Ventilator-Associated Pneumonia In A Tertiary Care Hospital In India: Role Of Multi-Drug Resistant Pathogens, J Infect Dev Ctries 2010; 4(4):218-225
- Nishat Hussain Ahmed1, Tabish Hussain2, Indu Biswal3, Antimicrobial Resistance Of Bacterial Isolates From Respiratory Secretions Of Ventilated Patients In A Multi-Specialty Hospital, Avicenna J Med 2015;5:74-8.
- Arindam Dey, Indira Bairy, Incidence Of Multidrug-Resistant Organisms Causing Ventilator-Associated Pneumonia In A Tertiary Care Hospital: A Nine Months’ Prospective Study Department Of Microbiology, Kasturba Medical College, Manipal, India, Ann Thorac Med. 2007 Apr-Jun; 2(2): 52–57.
- Neelima Ranjan, Uma Chaudhary, Dhruva Chaudhry, KP Ranjan, Ventilator-Associated Pneumonia In A Tertiary Care Intensive Care Unit: Analysis Of Incidence, Risk Factors And Mortality, Indian J Crit Care Med [serial online] 2014 [cited 2016 Jun 3];18:200-4.
- Relative Oral Bioavailability Study of Liposomal Curcumin
Authors
1 Shreepad Shree Vallabh SSV Phytopharmaceuticals, Mumbai, IN
2 TheraIndx LifeSciences, Pvt. Ltd., Bengaluru, IN
Source
The Indian Practitioner, Vol 73, No 10 (2020), Pagination: 21-25Abstract
Background: Curcumin is a naturally derived yellow polyphenolic compound from the rhizome Curcuma longa. Curcumin modulates various signalling pathways, such as Cyclooxygenase-2 (COX-2), Matrix metallopeptidases (MMPs), glutathione, protein kinase C, ATPase, nuclear Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-kb), Activator protein 1 (AP-1), P-glycoprotein 1 (P-gp), Multidrug resistance-associated proteins (MRP-1, MRP-2), Receptor tyrosine-protein kinase (ErbB2), Alpha-1-acid glycoprotein AGP), Cyclin D1 etc. Curcumin, as a free drug, has a short plasma half-life because it is rapidly metabolised in the liver. Its oral bioavailability is extremely poor, and hence Curcumin is classified as a class IV compound in the BCS system.
Materials and Methods: Authors of the current study have formulated Liposomal Curcumin and conducted a Relative Oral Bioavailability Study of Liposomal Curcumin in comparison with plain Curcumin in rats. The treatment group was given Curcumin 25% I lipo at the dose of 500 mg/kg body weight and the control group was given plain Curcumin 500 mg/ kg body weight of the rats.
Observations: Oral administration of Liposomal Curcumin showed rapid absorption (tmax =15 min) with Peak plasma concentration (Cmax), Area under Curve (AUC) and half-life (t1/2) of 42.3 ng/ml, 244 ng.h/ml and 5.5 h, respectively. In the control group, the Curcumin levels were below the level of quantitation (5.43 ng/ml).
Conclusion: This study shows that Liposomal Curcumin has higher bioavailability as compared to the marketed formulations of Curcumin. Further extensive clinical studies are needed to prove efficacy of Liposomal Curcumin in various human applications.
Keywords
Liposomal Curcumin, Bioavailability, Pharmacokinetics.References
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- Feng T, Wei Y, Lee RJ, Zhao L. Liposomal curcumin and its application in cancer. Int J Nanomedicine. 2017; 12: 6027-44.
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- He W, Zou C, Tian Z, Tan W, Shen W, Chen J, et al. Nasopharyngeal carcinoma treated with bevacizumab combined with paclitaxel liposome plus cisplatin: a case report and literature review. Onco Targets Ther. 2017; 10:67-72.
- Mahmud M, Piwoni A, Filipczak N, Janicka M, Gubernator J. Long-Circulating Curcumin-Loaded Liposome Formulations with High Incorporation Efficiency, Stability and Anticancer Activity towards Pancreatic Adenocarcinoma Cell Lines In Vitro. PLoS One. 2016; 11: e0167787.
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- Storka A, Vcelar B, Klickovic U, Gouya G, Weisshaar S, Aschauer S, et al. Safety, tolerability and pharmacokinetics of liposomal curcumin in healthy humans. Int J Clin Pharmacol Ther. 2015; 53: 54-65.
- Relative Bioavailability of Liposomal Vitamin C – ‘VitaLip-C’
Authors
1 Proprietor, Shreepad Shree Vallabh SSV Phytopharmaceuticals, Mumbai, India, IN
2 Research Associate, Shreepad Shree Vallabh SSV Phytopharmaceuticals, Mumbai, India, IN
Source
The Indian Practitioner, Vol 75, No 3 (2022), Pagination: 22-26Abstract
Background: Vitamin C is a water-soluble vitamin and one of the most commonly used vitamins. With increasing vitamin C intake, the plasma steady state concentration reaches a maximal level of about 70–80 µM. However, from the available literature, it appears that a daily intake of about 200–400 mg of vitamin C ensures saturation of the blood in healthy individuals. Bioavailability can be increased by various methods, such as encapsulation, micronisation, etc. VitaLip-C is a liposomal form of vitamin C, which is shown to be clinically proven and evaluated by Transmission Electron Microscopy (TEM) for the presence of liposomes.
Keywords
Vitamin C, liposome, relative bioavailability, pharmacokinetics, VitaLip-CReferences
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- Effect of a Novel Phytopharmaceutical Formulation with an Innovative Potential in Patients with Treated Uncontrolled Type 2 Diabetes Mellitus
Authors
1 Proprietor, Shreepad Shree Vallabh, SSV Phytopharmaceuticals, Mumbai, Maharashtra, India., IN
2 Consulting Physician, Kokan Hospital, Mumbai, Maharashtra, India., IN
Source
The Indian Practitioner, Vol 75, No 4 (2022), Pagination: 21-27Abstract
Background and Aims: Diabetes mellitus is a major health problem in India. The development of a new drug of natural origin that assures safety with moderate but definite efficacy is the need of the time. Authors have developed formulation containing phytoactives from Pterocarpus marsupium Roxb and Andrographis paniculata Nees in specific proportion for the first time, as an anti-diabetic supplement which improves the glycemic control. We aim to study the effect of PtyroneTM in patients with treated uncontrolled T2DM and its safety and tolerability.
Study Design: In an open labelled trial, 115 patients with T2DM were divided in three groups: Metformin, Metformin + Gliptins and Metformin + Sulphonylurea. PtyroneTM capsules were given to all the patients along with their OHA’s, orally twice a day for 12 weeks. Laboratory investigations were studied at the baseline and at fixed intervals till the end of the study.
Results: There was a statistically significant decrease (p value< 0.0001) in fasting and post prandial blood sugar along with triglycerides in all groups. There was reduction in levels of glycosylated haemoglobin also in all the groups. All other biochemical investigations were within normal limits. PtyroneTM capsules were well tolerated clinically and no serious adverse events were reported during the period of therapy.
Conclusion: The authors have shown, for the first time, the therapeutic potential of PtyroneTM at a dose of 450 mg twice a day supplemented along with anti-diabetic medications. This therapeutic efficacy needs to be evaluated further in a larger sample size, with a placebo/active controlled randomized double blind multicentric trial
Keywords
Treated uncontrolled type 2 diabetes mellitus, andrographolide, Pterostilbene, blood sugar, lipids.References
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- Dound YA, Chaudhary S, Rawat S, Alqarni MG, Ahmad MM, Geesi MH and Alam P. Novel Mechanistic Understanding of PtyroneTM: A Plant based Natural Anti-Diabetic Product. Journal of King Saud University - Science 2021;33(5):101454.
- Efficacy and Safety of Liposomal Curcumin in the Management of Pain due to Osteoarthritis
Authors
1 Proprietor, Shreepad Shree Vallabh, SSV Phytopharmaceuticals, IN
2 Consultant Orthopedist, Vakratund Hospital Pvt Ltd, PathardiPhata, Nashik, IN
Source
The Indian Practitioner, Vol 76, No 2 (2023), Pagination: 16-20Abstract
Aims and Background: The most prevalent chronic joint disease, which remains as one of the few chronic disorders of ageing is Osteoarthritis (OA). One of the predominant symptoms of OA is pain, with very little effective treatment and contributes to limitations in daily functioning. Therapy of pain due to OA includes pharmaceutical agents that need to be used in lowest possible dose to avoid adverse effects. Lot of advances have taken place in understanding the pathogenesis of OA, however, relief of pain have always remained an unfulfilled need. The anti-inflammatory property of Curcumin is mediated through the inhibition of induction of COX-2, LOX, iNOS and production of cytokines and tumor necrosis factor and activation of transcription factors like NF-κB, and AP-1. Its oral bioavailability is extremely poor.
Material and Methods: In the current study, Liposomal Curcumin was administered to 30 patients suffering from pain due to OA for 30 days. The therapeutic activity was assessed by reduction in the pain severity based on NPRS Score.
Results: By 30 days, there was statistically significant decrease in NPRS score. The pain reduced significantly along with decrease in weakness and fatigue. Improvement in daily physical functioning was shown by the WOMAC Arthritis Index. In 10 subjects the serum levels of Interleukin-6 (IL-6) and Tumour Necrosis Factor (TNF)α were examined at baseline and at 30th day. There was 76% improvement in TNF-α levels and 62% improvement in IL-6 levels in these subjects.
Conclusion: These results have shown for the first time in Indian population the efficacy of Liposomal Curcumin for OA Pain.
Keywords
Osteoarthritis, Pain, Liposomal Curcumin, Anti-Inflammatory.References
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