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Pandey, V.
- A Prospective Study of Adverse Drug Reactions Monitoring in a Tertiary Care Hospital, Rewa (MP)
Authors
1 Department of Pharmacology, S.S. Medical College, Rewa, (MP), IN
2 Department of Medicine, S.S. Medical College, Rewa, (MP), IN
Source
The Indian Practitioner, Vol 69, No 11 (2016), Pagination: 11-15Abstract
Aims and Objectives: The aim of study is to determine the pattern of suspected ADRs reported in ICU and ward admitted patients in a tertiary care hospital.
Material and methods: Study was conducted in the department of Pharmacology and department of Medicine, SS Medical College and SGM Hospital, Rewa, MP, during October 2014 to September 2015. Total 130 cases were enrolled in study that presented with suspected ADRs during study period, after taking written informed consent. Clinical evaluation and scrutiny of data was done to assess pattern, extent and duration of the suspected adverse drug reactions, affected organ system and involvement of therapeutic drugs classes as a part of the drug reaction.
Results: The result of this study showed that maximum (25%) patients belonged to the 18-25 years of age group, of these 55% was males and 45% were females. Mean (± SD) age of these patients was 34.84 ± 20.99 years. Among the reported suspected ADRs; maximum (26%) were skin rashes, followed by pruritus (15%), nausea, vomiting and rigor each occur 7%; Fever 6%, Apnea, oral ulcers and headache 3%. The most commonly affected organ system was skin and mucous membrane (44%), followed by central nervous system (11%), gastrointestinal system (10%), respiratory system (7%), and cardiovascular system (5%) in decreasing order. Of these; majority of suspected ADRs were associated with use of antimicrobials (68%), followed by NSAIDs (9%); Hematinics (5%); Antihypertensive, Antianginal, Antiepileptics, Hypoglycemis, Corticosteroids and Ionotrops (2%).
Conclusions: The Hospital-based monitoring of suspected ADRs is convenient but it is under reported and the limitation of these studies is that they do not yield the exact incidence of suspected ADRs associated with particular drug use.
Keywords
Drugs, Adverse Drug Reaction, Morbidity, Organ System.References
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- Cutaneous Adverse Drug Reaction (CADR): An Overview
Authors
1 Department of Pharmacology, S.S. Medical College, Rewa, (MP) – 486001, IN
2 Department of Physiology, S.S. Medical College, Rewa, (MP) – 486001, IN
3 Department of Anatomy, Sukh Sagar. Medical College & Hospital, Jabalpur, MP, IN
4 Department of Medicine, S.S. Medical College, Rewa, (MP) – 486001, IN
5 Department of Ayurveda Rewa, (MP) – 486001, IN
Source
The Indian Practitioner, Vol 70, No 1 (2017), Pagination: 11-15Abstract
Aims and Objectives: Aim of this prospective, hospital based study is to determine the pattern of cutaneous adverse drug reactions (ADR). Material and methods: The study was conducted in the department of Pharmacology and department of Medicine, at SS Medical College and associated SGM Hospital, Rewa, MP from Oct 2014 to Sept 2015; total 130 cases were enrolled with suspected ADRs. Results: In this study maximum (25%) patients belonged to 18-25 years of age group. Mean (± SD) age of these patients was 34.84 ± 20.99 years. The skin and mucous membrane are most commonly (52.29%) affected organ system with suspected ADRs followed by central nervous system (9.19%) and gastrointestinal system (8.62%). Among the cutaneous ADRs; 51.64% were skin rashes followed by 29.67% pruritus, 5.49% oral ulcers, 3.29% Stevens-Johnson syndrome (SJS), 2.19% bullous eruption, 2.19% lips swelling, 2.19% toxic epidermal necrolysis (TEN), 1.09% oral candidiasis, 1.09% red man syndrome and 1.09% hair changes. Of these ADRs; 82.41%were associated with use of antimicrobials followed by 14.28% NSAIDs. Amongst AMAs 20.97% ADRs were associated with fluoroquinolones, 18.68% with cephalosporin, 10.98% with penicillin and 5.49% with sulphonamide. Conclusions: In this study, skin and mucous membrane is most commonly (52.29%) affected organ system; skin rashes and pruritus are the most common cutaneous ADRs and majority of cases were associated with use of fluoroquinolones and cephalosporins AMAs.Keywords
Cutaneous Adverse Drug Reactions (CADR), Exanthematous Drug Eruptions, Antimicrobial Agents (AMAs), Fluoroquinolones.References
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