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Singh, J.
- Metronidazole in the Treatment of Amoebiasis
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Authors
Affiliations
1 Dept. of Haematology and Nuclear Medicine, Safdarjang Hospital, New Delhi, IN
2 Dept. of Haematology & Nuclear Medicine, Safdarjang Hospital, New Delhi, IN
3 Deparhnent of Biochemistry, All India Institute of Medical Sciences, New Delhi, IN
1 Dept. of Haematology and Nuclear Medicine, Safdarjang Hospital, New Delhi, IN
2 Dept. of Haematology & Nuclear Medicine, Safdarjang Hospital, New Delhi, IN
3 Deparhnent of Biochemistry, All India Institute of Medical Sciences, New Delhi, IN
Source
The Indian Practitioner, Vol 29, No 4 (1976), Pagination: 207-216Abstract
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- To Study the Prevalence of Iron Deficiency Anemia in Children Aged 6 Months-6 Years Presenting with Febrile Seizures in Department of Pediatrics
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Authors
Affiliations
1 Department of Pediatrics, Govt. Medical College, Patiala, IN
1 Department of Pediatrics, Govt. Medical College, Patiala, IN
Source
The Indian Practitioner, Vol 69, No 11 (2016), Pagination: 16-19Abstract
Background:- Febrile seizure is a common cause of seizures in young children but with an excellent prognosis. In addition to genetic predisposition, febrile seizures are generally thought to be induced by elemental changes such as iron deficiency. Regarding the high prevalence of febrile seizures with iron deficiency anemia in children, the aim of our study is to investigate the role of iron deficiency anemia in febrile seizures patients. Iron deficiency (ID) is the most common nutritional deficiency. The peak age for ID is between 1 and 2 years, which coincides with the peak incidence for febrile seizures. Aim: To study the prevalence of iron deficiency anemia in children aged 6 months to 6 years having febrile seizures. Study design: It is a prospective observational case control study. Material&Method: The present study was included 50 children aged 6 months to 6 years with febrile seizures (cases) and 30 febrile children without seizures (controls), coming to Pediatrics OPD and emergency, Rajindra Hospital Patiala. Hemoglobin level (Hb) and serum ferritin levels were estimated in all the patients. Results: In cases the mean serum ferritin levels was 25.52±2.9 ng/dl and in controls was 61.36±7.7 ng/dl. It was seen that serum ferritin levels were significantly low in children with febrile seizures as compared to controls (p < 0.004). Conclusion: Prophylactic iron supplementation should be considered in all children who are anemic as it may have a preventable role in febrile seizures.Keywords
Febrile Seizure, Iron Deficiency Anemia.References
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- Mikati MA. Febrile Seizures. In: Nelson Textbook of Pediatrics. Kliegman RM, Stanton BMD, Geme JS, Schor N, Behrman RE. 19th edn. 2011;586.1:2017.
- Hartfield DS, Tan J, Yager JY, Rosychuk RJ, Spady D, Haines C et al. The Association Between Iron Deficiency and Febrile Seizures in Childhood Clinical Pediatrics 2009;48(4)2009:420-26.
- Bidabadi E, Mashouf M. Association between iron def. Anemia & and first febrile convulsion: A case control study. Seizure 2009;18:347–51.
- Parks YA, Wharton BA. Iron deficiency and the brain. Acta Paediatr Scand 1989;55(suppl 361):71-7.
- Auvichayapat P, Auvichayapat N, Jedsrisuparp A, Thinkhamrop B et al. Incidence of Febrile Seizures in Thalassemic Patients. J Med Assoc Thai 2004;87(8):970-3.
- Pisacane A, Sansone R, Impagliazzo N, Coppola A, Rolando P, D’Apuzzo A et al. Iron deficiency anemia and febrile convulsions: case-control study in children under 2 years. BMJ 1996;313(7053):343.
- Vaswani RK,Dharaskar PG,Kulkarni S, Ghosh K. Iron Deficiency as a Risk Factor for First Febrile Seizure. Indian Pediatr 2010;47:437-39.
- Kumari PL, Nair MK, Nair SM, Kailas L, Geetha S. Iron deficiency as a risk factor for simple febrile seizures--a case control study. Indian Pediatr. 2012;49(1):17-9.
- Kobrinsky NL, Yager JY, Cheang MS, Yatscoff RW, Tenenbein M. Does iron deficiency raise the seizure threshold? J Child Neurol. 1995 Mar;10(2):105-9.
- Momen AA, Nikfar R, Karimi B. Evaluation of iron status in 9 months to 5 years old children with febrile seizures: a case controle study in south west of Iran. Iran J Child Neurology 2010;4(2):45-50.
- Daoud AS, Batieha A, Abu-Ekteish F, Gharaibeh N, Ajlouni S, Hijazi S. Iron status: a possible risk factor for the first febrile seizure. Epilepsia. 2002;43(7):740-3.
- Yager JY, Hartfield DS. Neurologic manifestations of iron deficiency in childhood. Pediatr Neurol. 2002;27(2):85-92.
- Naveed-ur-Rehman, Billoo AG. Association between Iron deficiency anemia and febrile seizures. J Coll Physicians Surg Pak. 2005;15(6):338-40.
- Miri-Aliabad G, Khajeh A, Arefi M. Iron Status and Iron Deficiency Anemia in Patients with Febrile Seizure. Zahedan J Res Med Sci 2013;15(9):14-17.
- Boshra A.T. Ahmed. Iron Deficiency as a Risk Factor for Simple Febrile Seizures Med. J. Cairo Univ. 2013;81(2): 51-54.
- Breathing Pattern in Healthy Preterm Babies
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Authors
Affiliations
1 Deptt. of Pediatrics, GMC, Patiala (Pb.), IN
1 Deptt. of Pediatrics, GMC, Patiala (Pb.), IN
Source
The Indian Practitioner, Vol 70, No 5 (2017), Pagination: 16-21Abstract
This observational study was conducted on 200 healthy preterm babies delivered in the department of Obstetrics and handled by the Neonatology section of Pediatrics department with the aim to study the breathing pattern in healthy preterm babies and to compare pattern of breathing with gestational age, birth weight and other relevant parameters. The breathing pattern was observed in all preterm babies starting from day 3 of life till the hospital stay. It was found that with increasing gestational age the incidence of Normal breathing increased while the incidence of Periodic breathing and Apnea decreased(table 1). Also a highly significant correlation between birth weight and breathing pattern was found with increase in incidence of periodic breathing and incidence of apneas in low birth weight babies (table 2). The incidence of periodic breathing in healthy Preterm infants was found to be 42% and rest 58% had normal breathing during the period of observation. The incidence of apnea of prematurity in preterm babies was found to be 5.5% (table 3).References
- Control of Breathing and Abnormal Breathing Patterns. Available at:http://d3jonline.tripod.com/20-Pulmonary_II/Control_of_Breathing_and _ Abnormal_Breathing_Patterns.htm.
- Vaughan D. Newborn Breathing Patterns. 2012. Available at: http://www.santanvalley.com/news/ health-news/item/8190-newborn-breathing-patterns.
- Steer P: The epidemiology of preterm labour. BJOG. 2005;112Suppl 1:1-3.
- Fenner A, Schalk U, Hoenicke H, Wendenburg A, Roehling T. Periodic breathing in premature and neonatal babies: Incidence, Breathing Pattern,Respiratory Gas Tentions, Response to Changes in the Composition of Ambient Air. Pediatr Res. 1973;7 (4) :174-83.
- Weintraub Z, Cates D, Kwiatkowski K, Al-Hathol K, Hussain A, Rigatto H. The morphology of periodic breathing in infants and adults. Respiratory Physiol. 2001;127:173-84.
- Engoren M, Courtney SE, Habib RH. Effect of weight and age on respiratory complexity in premature neonates. J Appl Physiol.2009;106 (3) :76673.
- Hoch B, Michael B. Central apnoea and periodic breathing in preterm twins compared with preterm singletons. Somnologie. 2004:8 (1) :20-24.
- Bouterline-Young HJ, Smith CA. Respiration of full-term and premature infants. Amer. J. Dis. Childhood 1950;80 (5) :753-66.
- Graham BD, Reardon HS, Wilson JL, Asao MU, Baumann ML. Physiologic and chemical response of premature infants to oxygen-enriched atmosphere. Pediatrics 1950;6 (1) : 55-71.
- Martin RJ, Abu Shaweesh JM, Baird TM. Apnoea of prematurity. Paediatr Respir Rev. 2004;5 Suppl 1:S377-S382.
- Cardiovascular Status in Regularly Transfused Thalassemia Major Children
Abstract Views :216 |
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Authors
Affiliations
1 Dept of Pediatrics, GMC, Patiala, Punjab, IN
2 GMC, Patiala, Punjab, IN
1 Dept of Pediatrics, GMC, Patiala, Punjab, IN
2 GMC, Patiala, Punjab, IN
Source
The Indian Practitioner, Vol 70, No 8 (2017), Pagination: 15-20Abstract
The study was conducted among 100 beta thalassemic children in the age group of 5 to 8 yrs, enrolled at the Thalassemia Unit, Department of Pediatrics, Rajindra Hospital, Patiala, who were diagnosed to have beta thalassemia for atleast 3 years. A detailed history, clinical examination, laboratory workup, electrocardiography and echocardiography were done as per the proforma attached.
Data was analyzed using Chi Square test for significance. The strength of association was assessed using Odd's ratio and its 95% confidence limits. Binary logistic regression analysis was done following a stepwise method, among variable with a value <0.1 in univariate analysis to eliminate confounders.
Among the 100 study subjects 14% had cardiac involvement. Most common age group with cardiac complications was 15 to 18 years (57.14%). Most common cardiac complication associated with beta thalassemia was left ventricular hypertrophy with 50% subjects detected by echocardiography, closely followed by systolic dysfunction. The determinants of cardiac complications among regularly transfused beta thalassemics were subjected to univariate analysis showed tachycardia (p 0.004), lower diastolic blood pressure (p 0.0028), irregular chelation therapy (0.045), higher number of blood pressure (p 0.043) and older age (p 0.000) to have statistically significant association (p<0.05) for cardiac complications. Determinants with p values <0.1 in univariate analysis were further analyzed using multivariate binary logistic stepwise regression. Higher number of blood transfusion (p 0.020), lower pre transfusion hemoglobin (p 0.045) and older age (p 0.003) were noted as the independent determinants of cardiac complications.
The important message to be put out from this study is the presence of factors which can suggest an impending cardiac involvement. Early detection of the same and checking the progression of the disease process to stem the eventual cardiac damage is possible and should be done regularly.
References
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- Kremastinos DT, Toutouzas PK, Vyssoulis GP, Venetis CA, Avgoustakis DG. Iron overload and left ventricular performance in beta thalassemia. Acta Cardiol 1984; 29-40.
- Kilegman, Stanton, St. Geme, Schor, Behrman, Neison Textbook Of Paediatrics, Volume 2, 19th edition, Elsevier Publications, 2011 pages 16741677.
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- Wood. JC., Enriquez. C, Ghugre. N, Otto-duessel M, Aguilar M,. Neison M D, et al Physiology and Pathophysiology of Iron Cardiomyopathy in Thalassemia Ann N Y Acad Sci. 2005; 1054: 386-395.
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- Rund D, Rachmilewitz E. Beta-thalassemia. N Engl J Med. 2055; 353: 1135-1146.
- Hahalis G, Manolis AS, Apostolopoulos D, Alexopoulos D, Vagenakis AG, Zoumbos NC. Right ventricular cardiomyopathy in betathalassaemiamajor. Eur Heart J. 2002; 23:147-156.
- Ladis V, Chouliaras G, Berdousi H, Kanavakis E, Kattamis C. Longitudinal study of survival and causes of death in patients with thalassemia major in greece. Ann N Y Acad Sci. 2005; 1054:445-450