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Gangadhar, A.
- Novel, Nanoparticle Based Liquid Oral Formulation of Vitamin D3 for Managing Vitamin-D Deficiency: a Survey of Doctor's Preferences and Practices in India
Authors
1 Medical Sciences Division, Abbott India Limited, 271, Business park, Model Industrial Colony, Off Aarey Road, Goregaon (E), Mumbai – 400063, IN
Source
The Indian Practitioner, Vol 69, No 3 (2016), Pagination: 26-31Abstract
Objective: To understand the overall opinion of Orthopedicians on their perceptions, practices and preferences regarding a nano-droplet formulation of vitamin-D3. (Arachitol-NANOTM).Design&Setting: Survey study conducted in 81 locations across India.
Methods: This was a cross-sectional survey study conducted across India, in both rural and urban regions spanning 81 locations. A total of 205 practicing orthopedicians were included in this survey. Data was compiled and analyzed from the responses received for a 10 item survey questionnaire. The questionnaire was designed to capture the perceptions, practices and preferences of Orthopedicians, based on their clinical experience with at least 25 patients with vitamin D deficiency, managed with Arachitol Nano.
Results: 77.77% doctors' responses suggested that Vitamin D Deficiency was present in more than 50% patients attending the clinics. From an orthopedician's clinical practice perspective, the most common age group affected by Vitamin D Deficiency was adults and elderly(87.91% responses). Approximately 60% responses received, favored a 'single-dose oral liquid formulation' of vitamin-D as the most convenient dosage format for the treatment of Vitamin D Deficiency. Responses from almost all the doctors (99.51%) suggested that the use of nanoparticles technology in vitamin D3 formulations could improve absorption of vitamin-D. While 67.53% of the doctors' responses recommended the use of Nano formulation for all patients with Vitamin D deficiency, the rest of the responses suggested its use in specific patient profiles of vitamin D deficiency. Approximately 99% of the responses received, rated the clinical experience with the nano droplet formulation to be good to excellent, both in terms of efficacy and tolerability. The responses also suggested that the nano droplet formulation is both, a convenient and an accepted format by the patient, reflected by the fact that more than 99.5% of the doctors' responses suggested it to be beneficial in their patients.
Conclusions: The study results reflect that Arachitol Nano has the acceptance of both doctors and patients as well, which is reiterated in the overwhelming number of responses from orthopedicians suggesting that Arachitol Nano would be beneficial for their patients with Vitamin D deficiency.
Keywords
Nano-Droplet, Nanoparticles, Nanotechnology, Vitamin-D Deficiency.
- A Randomised, Comparative Study to Evaluate the Efficacy and Tolerability of Two Fixed Dose Combinations of Camylofin & Mefenamic Acid and Dicyclomine & Mefenamic Acid in the Management of Primary Dysmenorrhea
Authors
1 Sakthi Hospital and Research Centre, IN
2 Abbott Healthcare Pvt Ltd, IN
Source
The Indian Practitioner, Vol 70, No 2 (2017), Pagination: 16-20Abstract
Primary dysmenorrhea (PD) is a common gynaecological disorder affecting nearly 50% of menstruating women. Camylofin combination with paracetamol has demonstrated superior efficacy than dicyclomine- paracetamol combination, in the treatment of colicky abdominal pain. However, comparative data on these two antispasmodics in combination with Mefenamic acid in PD is not available.
Aim: To compare the efficacy and tolerability of fixed dose combinations of Camylofin + Mefenamic acid and Dicyclomine + Mefenamic acid in patients with Primary Dysmenorrhea.
Methods: A randomised, open-label, comparative study, to evaluate the efficacy and tolerability of a fixed-dose combination of Camylofin 50 mg + Mefenamic acid 250 mg (Study Group) and Dicyclomine 10 mg + Mefenamic acid 250 mg (Control Group) in 50 PD patients.
Results: In the study group (Camylofin + Mefenamic Acid) the VAS scores reduced by 86% and 100% on day 3 and day 5 respectively as compared to a marginally less decrease in VAS scores by 82% and 95% on day 3 and day 5 respectively in the control group(P>0.05). Patients with complete pain relief (study end) were almost 96% and 88% patients in the study and control groups respectively (P>0.05). Global assessment of efficacy by the investigator showed that 73% of the patients in the study group were rated as 'Very Good' to 'Excellent' as compared to 54% of the patients in the control group (P>0.05).
Conclusion: These findings suggest that Camylofin + Mefenamic acid may be a better alternative to Dicyclomine + Mefenamic acid. However, the results did not attain statistical significance.
References
- Ramya Sugumar, Vasundara Krishnaiah et al. Comparison of the pattern, efficacy, and tolerability of self medicated drugs in primary dysmenorrhea: A questionnaire based survey. Indian J Pharmacol. 2013 MarApr; 45(2): 180–183.
- Marjoribanks J, Proctor M et al.Nonsteroidal antiinflammatory drugs for dysmenorrhoea. Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD001751
- V. G. Padubidri, Shirish N Daftary. Shaw’s Textbook of Gynecology. Elsevier Health Sciences. 2014; 472-473
- Kamini. A. Rao. Textbook Of Gynaecology. Elsevier India, 2009; 42-43
- Warke H, Chauhan A, Raut V, Ingle KM. Efficacy of camylofin dihydrochloride in acceleration of labour: A randomised double blind trial. Bombay Hospital Journal 2003; 45(3): 420–3
- C Gupta. Drug Trial Report-Use of Anafortan intravenous injection for treatment of colicky pain. J Indian Med Assoc. 98(8):497-482
- Mohd Ali, Manoj Naik et al. Open,randomized comparative study to evaluate efficacy, safety and tolerability of Anafortan Vs. dicyclomine+paracetamol in treatment of mild to moderate abdominal colic and spasmodic abdominal pain. Indian Medical Gazette.2010: 314-321
- Lefebvre G, Pinsonneault O et al. Primary dysmenorrhea consensus guideline. J Obstet Gynaecol Can. 2005 Dec;27(12):1117-46.
- Dabholkar KM. Mefenamic acid with dicyclomine is a highly effective and well tolerated treatment for spasmodic dysmenorrhea. The Indian Practitioner. 1999 Nov; 52(11): 767
- Rajani U, Binu P. A Randomized Comparative Study of Intramuscular Camylofin Dihydrochloride and Intravenous Drotaverine Hydrochloride on Cervical Dilatation in Labor. Indian Journal of Clinical Practice. 2015; 26(6):558-563
- Shridhar S. Dayama, Sunil S. Patil et al. A Randomised Controlled Study of Intramuscular Camylofin Dihydrochloride vs Intravenous Hyoscine Butylbromide in Augmentation of Labour. Global Journal of Medical Research: E Gynecology and Obstetrics. 2016; 16(1)
- K Sarbhjit, Bawja K. To Compare the Effect of Camylofin Dihydrochloride (Anafortin) with Combination of Valethamate Bromide (Epidosin) and Hyoscine ButylN-Bormide (Buscopan) on Cervical Dilation. Journal of Clinical and Diagnostic Research. 2013 Sept, 7(9): 1897-1899
- Abdominal Colic in Gynaecological Practice:A Cross Sectional Survey of Practices and Preferences in the Diagnosis and Management of Abdominal Colic in Indian Women and Usage of Anafortan Tablets in Gynaecological Practice
Authors
1 Medical Affairs, Abbott Healthcare Pvt. Ltd., IN
Source
The Indian Practitioner, Vol 71, No 1 (2018), Pagination: 17-22Abstract
Objective: To understand the preferences and practices in the diagnosis and management of abdominal colic in Indian women from a gynaecologist perspective and the usage of Anafortan Tablets in gynaecological practice.
Design & Setting: Survey conducted in 18 locations across India.
Methods: A cross-sectional, interview based, survey conducted across India, in both rural and urban regions, spanning 18 locations. A total of 200 practicing gynaecologists were included in this survey. Data was compiled and analysed from the responses received for a 15 item survey questionnaire. The questionnaire was designed to capture the practices and preferences of gynaecologists in the diagnosis and treatment of abdominal colic in their clinical practice and their perceptions on the attributes of an oral antispasmodic-analgesic combination-Anafortan (Camylofin+Paracetamol), based on their clinical experience in managing abdominal colic cases with this combination.
Results: A total of 200 practicing gynaecologists were included in the survey. Respondent experience on the disease profiles of patients managed by them in routine practice, included menstrual issues, menopause, pregnancy and colic pain related cases, followed by UTI and other conditions. The most common type of colic presentation was menstrual colic and pregnancy associated pain, followed by renal colic, GI colic, UTI related pain and biliary colic. Majority of the respondents indicated that they manage almost all the colic cases in their practice with antispasmodics. Camylofin was considered as a more suitable molecule for women with colic pain compared to drotaverine, dicyclomine and hyoscine. Further, Camylofin was rated as the most potent antispasmodic by respondents, followed by dicyclomine, hyoscine and drotaverine.On the tolerability front amongst anti-spasmodics, camylofin was rated as having superior tolerability by majority respondents, as compared to hyoscine, drotaverine and dicyclomine. Anafortan combination seemed to be considered by more respondents in intestinal colic patients. A high proportion of respondents rated Anafortan as having high potency. A very high proportion of gynaecologists considered the use of Anafortan to have 'High' to 'Very High' impact on the quality of life of their patients. Amongst reasons to prefer Anafortan, quick onset of action emerged the strongest reason, followed by its potency, long duration of action and good tolerability.
Conclusions: The findings of the current survey suggest that gynaecologists encounter different types of colic pain patients, with menstrual colic topping the diagnosis charts. Majority of the doctors recommend antispasmodics for the management of colic pain in most of their patients. Camylofin was considered as a suitable molecule for female patients by more gynaecologists compared to other antispasmodics like dicyclomine, drotaverine and hyoscine. Camylofin was also considered as the anti-spasmodic which has the highest potency and tolerability compared to dicyclomine, drotaverine and hyoscine by a higher proportion of gynaecologists. Quick onset of action, high potency, long duration of action and good tolerability are the key reasons for a gynaecologist to recommend Anafortan in their patients with colic pain.
References
- Anantharaman V. V, Logaraj Muthunarayanan. Prevalence of pain among female patients attending mobile medical camp in a rural block of Tamilnadu, India. Int J Community Med Public Health. 2016; 3(6):1606-1611
- Andrieli Daiane Zdanski de Souza, Marjoriê da Costa Mendieta et al. Menstrual cramps: A new therapeutic alternative care through medicinal plants. Health. 2013;5: 1106-1109
- Bernard Karnath, William Mileski. Acute Abdominal Pain-Review of clinical signs. Hospital Physician; 2002:4550
- Sarah L. Cartwright, Mark P. Knudson. Evaluation of Acute Abdominal Pain in Adults. American Family Physician. 2008;77(7): 971-978
- Mool Raj Kural, Naziya Nagori Noor et al. Menstrual characteristics and prevalence of dysmenorrhea in college going girls. Journal of Family Medicine and Primary Care. 2015; 4(3): 426-431
- Suresh K. Kumbhar, Mrudula Reddy et al. Prevalence of dysmenorrhea among adolescent girls (14-19 yrs) of kadapa district and its impact on quality of life: a cross sectional study. National Journal of Community Medicine. 2011; 2(2): 265-268
- N. Mayadeo, A. Gangadhar et al. Camylofin in the management of prolonged labor: a review of evidence. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2017; 6(3):776-780.
- S. Dhandapani, A. Gangadhar et al. A Randomised, Comparative Study to Evaluate the Efficacy and Tolerability of Two Fixed Dose Combinations of Camylofin & Mefenamic Acid and Dicyclomine & Mefenamic Acid in the Management of Primary Dysmenorrhea. The Indian Practitioner. 2017; 70 (2): 1620.