A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Singh, Ravinder
- Comparison of Efficacy and Tolerability of Aceclofenac and Diclofenac in Osteoarthritis of Knee Joint
Authors
1 General hospital, Narainangarh, Haryana, IN
2 Pharmacology, Govt. Medical College, Patiala, Punjab, IN
3 Orthopaedics Gian Sagar Medical College & Hospital, Ram Nagar, Banur, Patiala, IN
Source
International Journal of Medical and Dental Sciences, Vol 4, No 2 (2015), Pagination: 745-750Abstract
Background: Osteoarthritis is a slowly progressive disorder associated with a hyaline cartilage loss. Non-steroidal anti-inflammatory drugs play a pertinent role in management of osteoarthritis.
Objectives: The study was carried out for the comparison of efficacy and tolerability of Aceclofenac and Diclofenac in patients of osteoarthritis of knee joint.
Material and Methods: It is a randomised parallel group double blinded study. The study included 60 patients of confirmed osteoarthritis of knee joint, 30 patients were given Aceclofenac and 30 patients were given Diclofenac after food for 8 weeks and the patients were evaluated and compared statistically for pain intensity by VAS Score, Joint tenderness, Swelling, Erythema, Pain on movement, Functional capacity and Overall Assessment on LIKERT Scale.
Results: Both the drugs caused marked improvements in the parameters of - Pain intensity, Joint tenderness, Swelling, Erythema, Pain on movement of OA knee joint but there was increased improvement in all the parameters with aceclofenac.
Conclusion: Aceclofenac is the NSAID of choice in the osteoarthritis of knee joint as compare to Diclofenac.
Keywords
NSAID, Osteoarthritis, Aceclofenac, Diclofenac, Joint.Full Text
References
- Brandt KD. Osteoarthritis. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL editors. Harrison’s Principles of Internal Medicine. 16th ed. New YORK: Mc Graw-HILL;2005.p.2036-2045.
- Anderson JJ, Felson DT. Factors associated with osteoarthritis of the knee in the first National Health and Nutrition Examination Survey (HANES I). Evidence for an association with overweight, race and physical demands of work. Am J Epidemiol 1988;128:179-89.
- Brandt KD, Radin EL, Dieppe PA, Van de Putte L. Yet more evidence that osteoarthritis is not a cartilage disease. Ann Rheum Dis 2006;65(10):1261–1264.
- Bedson J, Jordan K, Croft P. The prevalence and history of knee osteoarthritis in general practice: a case control study. Fam Pract 2005;22:103-108.
- Felson DT, Zhang Y, Anthony JM, Naimark A, Anderson JJ. Weight loss reduces the risk of symptomatic knee osteoarthritis in women: The Framingham Study. Ann Intern Med 1992; 116:535-39.
- Felson DT, Anderson J, Naimark A. Obesity and knee Osteoarthritis: The Farmigham Study. Ann Int Med 1991;18:109.
- Felson DT, Zhang Y, Hannan MT, Naimark A, Weissman BN, Aliabadi P, et al. The incidence and natural history of knee osteoarthritis in the elderly. The Framingham osteoarthritis Study. Arthritis Rheum 1995;38:1500-1505.
- Blobaum AL, Marnett LJ. Molecular determinants for the selective inhibition of cyclo-oxygenase-2 by lumiracoxib. J Biol Chem 2007;282:16379–90.
- Burian M, Tegeder I, Seegel M, Geisslinger G. Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain. Clin Pharmacol Ther 2003;74:113–20.
- Dooley M, Spencer CM, Dunn CJ. Aceclofenac. A Reappraisal of its use in the management of pain and rheumatic disease. Drugs 2001;61(9):1351-78.
- Reginster JY, Paul L, Henrotin Y. What is the role of aceclofenac in the therapeutic arsenal against chronic osteoarthritis pathologies? Rev Med Liege 2001 Jul;56(7):484-8.
- Hart DJ, Spector TD. Radiographic criteria for epidemiological studies of osteo arthriti rheumatol 1995;22(43):46-48.
- Burke A, Smyth E, Fitzgerald GA. Analgesics – Antipyretic agents, Pharmacotherapy of gout. In: Brunton LC, Lazo JS, Parker KL editors. Goodman and Gilman’s pharmacological basis of therapeutics. 11th edn. New York: McGraw Hill; 2006.p.671-715.
- Hochberg MC. Osteoarthritis: Clinical features and treatment. In: Hochberg MC, editor. Primer on the Rheumatic diseases. 11th edn. Atlanta: Arthritis Foundation; 1997.p.218- 221.
- Ward DE, Veys EM, Bowdler JM. Comparison of aceclofenac with diclofenac in the treatment of osteoarthritis. Clin Rheumatol 1995 Nov;14:656-62.
- Kornasoff D, Frerick H, Bowdler J, Montull E. Aceclofenac is a well tolerated alternative to Naproxen in the treatment of osteoarthritis. Clin Rheumatol 1997 Jan;16(1):32-8.
- Diaz C, Rodriguez de la Serna A, Geli C, Belmonte MA, Olmedo J, Bltran J. Efficacy and tolerability of aceclofenac versus diclofenac in the treatment of knee arthritis: a multicentre study. Eur J Rheumatol Inflamm 1996;16(1):17-22.
- Gualda EB, Ivorra JR, Mola EM, Abello JC, Ferrando LFL, Molina JT, et al. Aceclofenac vs paracetamol in the management of symptomatic osteoarthritis of the knee: a double blind 6 week randomized controlled trial. Osteoarthritis and cartilage 2007;15(8):900-908.
- Role of Ilizarov Ring Fixator in Infected Non Union Tibia
Authors
1 PIMS, Jalandhar, Punjab, IN
2 PIMS, Jalandhar, Punjab, India, IN
3 Department of Orthopaedics, Government Medical college, Patiala, Punjab, IN
Source
International Journal of Medical and Dental Sciences, Vol 3, No 2 (2014), Pagination: 451-459Abstract
Background: The main surgical principle in the management of diaphyseal bone infection is thorough debridement of all nonviable tissue. None of the previously mentioned techniques afford surgeon the ability to correct deformities, eliminate antibiotic therapy, regenerate new bone without grafts and allow weight bearing during treatment.
Objectives: The present study was conducted to evaluate the clinical follow-up results with Ilizarov technique using three parameters: union, infection and function and to know the complications if any faced by the patients.
Material and Methods: This was a prospective study planned to evaluate the results of Ilizarov ring fixator on follow-up of 18 cases of either sex with infected non-union tibia. Average age of presentation was 34.5 years. Follow-up roentgenographs were used to assess alignment, bone contact and later callus formation. Healing status of the fracture was monitored using biplane roentgenographs, unchanged fracture alignment with loosening of the frame, absence of pain during ambulation with the frame destabilized. The data thus collected were analysed by using percentage and valid conclusions were drawn.
Result: Pain and swelling were the most common complication after application of ilizarov ring fixator. In this study of 18 cases, 11 (61.11%) patients had excellent, 2 (11.11%) good, 5 (27.77%) fair and none had poor results as per criterion laid down by Catteneo et al.
Conclusion: Ilizarov technique was found to be useful to progressively lengthen the extremity, achieve union without bone grafting and to correct deformities in infected non-union with or without bone gap.
Keywords
Ilizarov Ring Fixator, Non Union Tibia, Infection, Compression, Distraction.Full Text
References
- Cattaneo R, Cattagni M, Johnson EE. The treatment of infected nonunions and segmental defects of the tibia by methods of llizaro. Clin Orthop 1992;280:143-152.
- Green SA. Editiorial comment.Clin Orthop 1992;280:2-6.
- Ilizarov GA. Tension stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft tissue preservation. Clin Orthop 1989;238:249-81.
- Moore and Dahl quoted by DiParquale D, M Ochsner, Kelly AM, Maloney DM. The llizarov method for complex fractures nonunion. The Journal of Trauma 1999;37(4):630631.
- Ong CT, Choson DSK, Cabrera NP, Maffulli N. The treatment of open tibial fractures and of tibial nonunion with a novel external fixator. Injury Int J Care Injured 2002;33:829-834.
- Lalit M, Chadha M, Vishwanath J, Kapoor S, Mehtani A, Dhaon BK. The llizarov method in infected nonunion of fractures. Injury Int J Care Injured 2000;31:509-517.
- Honsy G, Shawky MS. The treatment of infected nonunion of the tibia by compression-distraction techniques using the llizarov external fixator. Internal Orthopaedics (SICOT) 1998;22:298-302.
- Patel VR, Menon DK, Poot RD, Simonis RB. Nonunion of the humerus after failure of surgical treatment, management using the llizarov circular fixator. JBJS 2000;82B(7):97-983.
- Dandrinos GK, Kontos G, Cyritsis E. Use of llizarov techniques for treatment of nonunion of tibia associated with infection. JBJS (Amer)1995;77(6):835-46.
- Paley D, Maurizio A, Catagni. llizarov treatment of tibial nonunion with bone loss. Clin Orthop 1989;241:146-164.
- Thirumal M, Shong HK. Bone transport in the management of fractures of the tibia. Med J Malaysia 2001;56(1):44-52.
- Dooren D, Oschsner MG, Marie AK, Maloney DM. The Ilizarov method for complex fracture non unions. The Journal of trauma 1994;37(4):629-634.
- Vladamir S, Sidney NM, Ronald AR, Roman S. Tibial Fractures- The llizarov Alternative 1992;278:207216.
- Aldegheri R. Distraction osteogenesis for lengthening of the tibia in patients who have limblength discrepancy or short stature. JBJS 1999;81(A):624-634.
- Tucker H, Kindra J, Todd E. Management of unstable open and closed tibial fractures by llizarov methods. Clin Orthop 1992;125:280.
- Changing Paradigm of Doctor Patient Relationship-Issues of Cost, Communication, Compassion, Consumerism or More?
Authors
1 Fortis Escorts Hospital, Amritsar, Punjab, IN
2 Dept of Minimal Access and Bariatric Surgery, Fortis Escorts Hospital, Amritsar, Punjab, IN
Source
International Journal of Medical and Dental Sciences, Vol 6, No 1 (2017), Pagination: 1350-1351Abstract
Ilhealth is always considered an uninvited guest and so is the pain of spending for it. For something that is unexpected and unwelcome, a negative sentiment gets tagged with it at the very start itself. It someone falls sick, there is a feeling of victimization by the force unknown. These are the pack of emotions with which a patients walks into hospital surrounded by anxious, restless attendants and most of the anxiety and disturbed look is borne out of the forced eventuality of accompanying their own kin. Another pertinent cause is the loss of the working days which are not easy to afford in the present era of cut throat competition. And not to lag behind is the constant prayer buzzing in their mind wishing a quick discharge and slim as a Barbie doll hospital bill.Full Text
References
- A Banerjee, D Sanyal. Dynamics of doctor patient relationship: A cross sectional study on concordance, trust and patient enablement. J Family community Med 2012 Jan Apr;19(1):12-9.
- Ambesh P. Violence against doctors in the Indian tub continent: A rising bane. Indian heart Journal 2016;68(5):749-50.