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Kaur, R.
- Cardiodepressant Activity of Newer Dihydropyrimidine Derivative in Comparison to Nifedipine on Perfused Rabbits Heart
Authors
1 Department of Pharmacology, Punjab Institute of Medical Sciences (PIMS), Jalandhar, Punjab, IN
2 GMC, Patiala, Punjab, IN
3 Punjabi University, Patiala, Punjab, IN
4 Genesis Institute of Dental Sciences & Research, Ferozepur, Punjab, IN
Source
International Journal of Medical and Dental Sciences, Vol 1, No 2 (2012), Pagination: 6-14Abstract
Background: Substituted dihydropyridine calcium channel blockers are used in the treatment of cardiovascular diseases. Dihydropyridines are considered as analogue of dihydropyrimidines.
Objectives: In present study newly synthesized test compound 5- Acyl-6-methyl-4(2',3'-methylenedioxy) phenyl - 2 - S - ethyl - 1, 4- dihydropyrimidine, a dihydropyrimidine derivative was investigated with an aim to get valuable substitute for the well known dihydropyridine, Nifedipine.
Material & Methods: The Calcium Channel blocking actiuity of test compound was studied on Rabbit's Heart and its effects were compared with Nifedipine used as control.
Results: Test compound has dose-dependent negative chronotropic and negative inotropic effect on Rabbit's heart but these effects appeared at doses higher than those of Nifedipine. Test compound had no significant change in coronary flow however Nifedipine show significant increase in coronary flow at lower doses.
Conclusion: Test compound appears to be less potent myocardial depressant compared to Nifedipine. Test compound produced calcium channel blocking activity which was dose related and in order to ascertain the status of this compound as a drug, further studies are needed not only in other animals and tissue models but also in various pathophysiological models.
Keywords
Test Compound (5-Acyl-6-Methyl-4(2’,3’-Methylenedioxy) Phenyl - 2 - S - Ethyl - 1, 4-Dihydropyrimidine), DMSO (Dimethylsulphoxide), Nifedipine.Full Text
- Effect of Antihypertensive Drugs on Quality of Life in Elderly Patients
Authors
1 Genesis Institute of Dental Sciences and Research Ferozepur, Punjab, IN
2 Punjab Institute of Medical Sciences Jalandhar, Punjab, IN
3 Christian medical college &hospital Ludhiana, Punjab, IN
Source
International Journal of Medical and Dental Sciences, Vol 1, No 1 (2012), Pagination: 9-13Abstract
The use of drugs to increase human happiness and to improve the quality of life physically, mentally and socioeconomically is a serious matter of concern. Chronic disabling conditions become common in old age and affect the quality of life. Quality of life (QOL) is an important measure of health care, which measures the gap between expectations and achievements. Effect of Drug use on quality of life in elderly Indian population with hypertension was studied using Mc Master Health Index. The study population was divided into test group (hypertensive patients on regular treatment) and control group (Not on any treatment or on treatment for less than 3 months). All three parameters of QOL namely physical, emotional and social were studied using Mc Master Health Index questionnaire. The results were statistically compared using ANOVA and chi square. Our results point toward better overall QOL in patients on regular treatment.Keywords
Quality of Life, Hypertension, Elderly.Full Text