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Mahajan, Amita
- Magnesium Sulphate as a Tocolytic Agent in Preterm Labour
Authors
1 Department of obstetrics and Gynaecology, Punjab Institute of Medical Sciences, Jalandhar, Punjab, IN
Source
International Journal of Medical and Dental Sciences, Vol 4, No 1 (2015), Pagination: 618-623Abstract
Background: Prematurity and its prevention continue to be a major challenge for both the obstetrician and neonatologist. Preterm labour is the most common obstetrical complication associated with perinatal deaths. Despite all advances in neonatology, the delivery of a preterm neonate is a clinical crisis that threatens the life and health of an infant. The obstetrician thus faces the challenge of affecting the delivery in such a way as to optimize the status of fetus-infant at birth. It is far more preferable to prevent the intiation of preterm labour than once the cascade of events has already been established.
Objective: To assess the efficacy of magnesium sulphate as a tocolytic agent in preterm labour.
Material and Methods: 50 pregnant patients with gestational age 28- 37 weeks with cervical dilatation not more than 3cm and cervical effacement not more than 50 % with intact membranes with regular uterine contractions with a frequency of 2 or more per 10 minutes lasting for at least 30 seconds were put on magnesium sulphate.
Results: Magnesium sulphate was successful in attaining tocolysis in majority of patients and had no adverse effects on immediate neonatal out come.
Conclusion: Magnesium sulphate is effective, safe and well tolerated tocolytic agent with no adverse effects on the fetus-infant.
Keywords
Magnesium Sulphate, Preterm Labour, Tocolytic Agent, Perinatal, Premature.Full Text
- Study of Risk Factors for Preterm Births in a Teaching Hospital: A Prospective Study
Authors
1 Department of Obstetrics and Gynaecology, Punjab Institute of Medical Sciences, Jalandhar, Punjab, IN
Source
International Journal of Medical and Dental Sciences, Vol 6, No 1 (2017), Pagination: 1407-1412Abstract
Background: Preterm birth is a leading cause of perinatal mortality and long term morbidity as well as the long term health consequences and neurodevelopmental outcome.
Objectives: To study the relationship between sociodemographic factors, obstetric, fetal factors, chronic maternal diseases and preterm births and to study the percentage of late preterm, moderately preterm and very preterm births.
Material and Methods: 100 preterm births (cases) and 100 term births (control cases) which took place in Department of Obstetrics and Gynaecology of a teaching hospital were enrolled in the study. A detailed questionnaire was used to record sociodemographic factors, maternal and antenatal characteristics of current and previous pregnancies. Data was analyzed.
Results: Pre-eclampsia (p<0.01), preterm prelabour rupture of membranes (p<0.01), previous history of preterm births (p<0.01), IUD (p<0.05), genitourinary infections (p<0.02) and polyhydramnios or oligohydramnios (p<0.05) were determined as significant risk factors for preterm birth. 53.1% preterm babies were late preterm babies.
Conclusions: Early detection and treatment of diseases or disorders among pregnant women especially hypertension, genitourinary infections, oligohydramnios/ polyhydramnios as well as improving health care quality delivered to pregnant women may reduce the risk of preterm births according to our study.
Keywords
PIH, Preterm Birth, Oligohydramnios, Polyhydramnios, Preterm Prelabour Rupture of Membranes.Full Text
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- The Effect of Supplementation of Standard Antibiotic Therapy with Oral Probiotics for Bacterial Vaginosis
Authors
1 Punjab Institute of Medical Sciences, Jalandhar, Punjab, IN
Source
International Journal of Medical and Dental Sciences, Vol 7, No 1 (2018), Pagination: 1628-1631Abstract
Background: Bacterial vaginosis is a common cause of vaginal infection worldwide in women of child bearing age. It can be asymptomatic or mild infection but can lead to many complications especially during pregnancy. Recurrence is also frequently seen in women suffering from bacterial vaginosis. This infection usually occurs when normal lactobacillus flora in vagina is disrupted and replaced by pathogens. Administration of probiotics will restore normal vaginal flora and maintain normal pH and it could prove to be a reliable alternative to antibiotics in future.
Objective: To assess the effect of supplementation of standard antibiotic therapy with oral probiotics (Lactobacillus) for treatment of bacterial vaginosis.
Material Methods: It was an open labeled prospective study in which 100 women diagnosed with bacterial vaginosis were randomly divided into two groups. Diagnosis was made using Amsel’s criteria and Nugent scoring was done. Group A was given Oral Metronidazole, 400 mg BD for 7 days along with oral probiotic tablet containing Lactobacillus rhamnosus BD for 6 weeks whereas Group B was administered Oral Metronidazole, 400 mg BD for 7 days. Patients were assessed at 7 days for symptomatic improvement and again at the end of 6 weeks using Nugent scores. Results obtained were then compared.
Results: Out of all patients 2 patients in Group A and 5 patients in Group B could not complete the study. At the end of 7 days, there was improvement in symptoms ie decrease in itching, odour and discharge. There was a significant difference in mean Nugent score before and after treatment between group A and group B at the end of 6 weeks.
Conclusion: This study concluded that improvement in patients taking probiotics along with standard antibiotic therapy was significantly more as compared to antibiotics alone.
Keywords
Nugent Score, Metronidazole, Amsels Criteria, Prebiotics, Vaginal Infections.Full Text
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