International Journal of Innovative Research and Development

Abstract

Substituted quinoline derivatives are found as substructures in natural products as well as in synthetic molecules. They find use in therapeutics because of their biological properties such as antimalarial, anti-inflammatory, antihypertensive and tyrosine kinase PDGF-RTK inhibiting activity. These pharmacological properties have prompted the researchers to give significant importance for the construction of these compounds by new synthetic routes. Present work reports the synthesis of a series of polysubstituted quinolines by a one-pot four-component reaction from araldehydes, dimedone, malononitrile and anilines in the presence of a readily available low cost organocatalyst: imidazole in water as a reaction medium. The mild reaction conditions and operational simplicity are the main advantages of this protocol.

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