Chemopharmacological Correlation Of Antidepressant Structures For Drug-Design

The chemopharmacological correlation is based on the principles of chemical pharmacology. Possibly it may be new attempt to design antidepressant of therapeutical specificity, by correlating the antidepressive  structures of natural origin and synthetic through molecular association or simplification. Serotonim and Norepinepherine selected as the structural standards. They have Indolyl, catechol, aliphatic chain of two carbons and the protonated tertiary nitrogen at the physiological pH are topographical entities for the receptor affinity and intrinsic efficacy of pharmacodynamic value, thus induce the conformational change for the biological response.The structural diveregence of non-SSRIs was rationalized by agumentation, receptor diversification and topographical selectivity. Mitrazepin, Neurontin, Pregabalin and Tramadol have special structural values. Receptor specificity and critical moieties of agonist, partial agonist and antagonist studied  for finding out their role in correlation. The overall chemopharmacological correlation has empirically defined the partial components of antidepressive receptor specificity as indolyl, tertiary nitrogen, catechol and aryls. The concepts of isosterism and bioisosterism were not considered. The topographical entities of antidepressants belonging to natural and synthetic, termed as critical for utilizing them for the molecular design.