Concentration Dependent Physical Behaviour of Superparamagnetic Iron Oxide NanoparticleMR Contrast Agents

Magnetic Resonance Imaging (MRI) is a high resolution diagnostic imaging modality without radiation. Superparamagnetic (SPIO)iron oxide contrast agents are useful to enhance the detection of liver pathology in MR technique.Considering the physiochemical properties of these contrast agents, the particle size plays an important roleas it is a valuable indicator of the efficiency. Therefore, the objective of this study was to evaluate and compare the mean hydrodynamic particle diameter in two types of commonly used superparamagnetic MRI contrast agents, with respect to their concentrations. Measurements onmean hydrodynamicdiameters of Feridex and Resovist were performed in an aqueous medium by Dynamic Light Scattering (DSL) technique. According to the results,specific relationship between the diameters with the concentrations of the considered SPIO was unable to establishin this study. However, a larger surface area was demonstrated for Feridex with comparable to Resovist.