International Journal of Health Research and Medico Legal Practice

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Erythrocyte Plasma Membrane Redox System, Plasma Vitamin C and Protein Carbonyl in Carcinoma Cervix Patients


Affiliations
1 R G Kar Medical College, Kolkata-004, West Bengal, India
2 ICARE Institute of Medical Science and Research, Haldia, Purba Medinipur- 721631, West Bengal, India
 

Introduction: Though cervical cancer is a multi-factorial disease, the importance of oxidative stress in the pathogenesis cannot be underestimated.

Methods: 40 cervical cancer patients (10 patients of each stage) and 40 age matched female controls were recruited for the study. Plasmaascorbate, protein carbonyl and erythrocyte plasma membrane redox system (PMRS) were studied in each subject.

Results: Compared to controls plasma protein carbonyl and erythrocyte plasma membrane redox system are significantly higher and plasma ascorbate is significantly lower in cervical cancer.

Conclusion: For the first time we have showed significant increase of erythrocyte PMRS activity in cervical cancer to mitigate oxidative stress in the body.


Keywords

Carcinoma Cervix, Protein Carbonyl, PMRS Activity.
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  • Erythrocyte Plasma Membrane Redox System, Plasma Vitamin C and Protein Carbonyl in Carcinoma Cervix Patients

Abstract Views: 160  |  PDF Views: 72

Authors

Banerjee Ivy
R G Kar Medical College, Kolkata-004, West Bengal, India
Mukherjee Amrita
R G Kar Medical College, Kolkata-004, West Bengal, India
Lahiri Surajit
ICARE Institute of Medical Science and Research, Haldia, Purba Medinipur- 721631, West Bengal, India
Rout Jayanta Kumar
R G Kar Medical College, Kolkata-004, West Bengal, India
Ghosh Debdutta
R G Kar Medical College, Kolkata-004, West Bengal, India
Sarkar Chandan
R G Kar Medical College, Kolkata-004, West Bengal, India

Abstract


Introduction: Though cervical cancer is a multi-factorial disease, the importance of oxidative stress in the pathogenesis cannot be underestimated.

Methods: 40 cervical cancer patients (10 patients of each stage) and 40 age matched female controls were recruited for the study. Plasmaascorbate, protein carbonyl and erythrocyte plasma membrane redox system (PMRS) were studied in each subject.

Results: Compared to controls plasma protein carbonyl and erythrocyte plasma membrane redox system are significantly higher and plasma ascorbate is significantly lower in cervical cancer.

Conclusion: For the first time we have showed significant increase of erythrocyte PMRS activity in cervical cancer to mitigate oxidative stress in the body.


Keywords


Carcinoma Cervix, Protein Carbonyl, PMRS Activity.