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Pheochromocytoma:A Case Report


Affiliations
1 Assam Medical College, Dibrugarh, Assam, India
2 Gauhati Medical College, Guwahati, Assam, India
 

Pheochromocytoma refers to the intra adrenal chromaffin neoplasm which is derived from neuroblast from neural crest. Signs and symptoms associated with pheochromocytoma are due to excessive secretion of catecholamines. 65% to 70% cases are sporadic and 30% to35% are manifestation of inherited tumor syndromes. There is germline mutation in gene which encode B, C and D subunit of Succinate dehydrogenase (SDH). Here, we present a case of a 50 year old male patient presenting with paroxysmal attacks of hypertention, palpitation, dizziness, blurring of vision and headache for six month. Clinically he had high systolic and diastolic blood pressure. Radiological imaging studies (CT scan) and abdominal ultrasonography suggested suspected left adrenocortical carcinoma. However histopathological (HP) and immunohistochemical (IHC) examinations confirm the diagnosis of pheochromocytoma. Appropiate diagnosis of pheochromocytoma is important to avoid fatal concequences due to excessive secretion of catecholamines. Moreover, it is a cause of surgically correctable hypertention.

Keywords

Pheochromocytoma, Hypertention, Histopathology, Immunohistochemistry.
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  • Pheochromocytoma:A Case Report

Abstract Views: 146  |  PDF Views: 67

Authors

Junu Devi
Assam Medical College, Dibrugarh, Assam, India
Mayurpankhi Saikia
Gauhati Medical College, Guwahati, Assam, India

Abstract


Pheochromocytoma refers to the intra adrenal chromaffin neoplasm which is derived from neuroblast from neural crest. Signs and symptoms associated with pheochromocytoma are due to excessive secretion of catecholamines. 65% to 70% cases are sporadic and 30% to35% are manifestation of inherited tumor syndromes. There is germline mutation in gene which encode B, C and D subunit of Succinate dehydrogenase (SDH). Here, we present a case of a 50 year old male patient presenting with paroxysmal attacks of hypertention, palpitation, dizziness, blurring of vision and headache for six month. Clinically he had high systolic and diastolic blood pressure. Radiological imaging studies (CT scan) and abdominal ultrasonography suggested suspected left adrenocortical carcinoma. However histopathological (HP) and immunohistochemical (IHC) examinations confirm the diagnosis of pheochromocytoma. Appropiate diagnosis of pheochromocytoma is important to avoid fatal concequences due to excessive secretion of catecholamines. Moreover, it is a cause of surgically correctable hypertention.

Keywords


Pheochromocytoma, Hypertention, Histopathology, Immunohistochemistry.

References