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Clinical Study of Cardiovascular Complications in Chronic Kidney Disease Patients with Special Reference to Echocardiography


Affiliations
1 Dept of Nephrology, Gauhati Medical College and Hospital, Guwahati, Assam, India
2 Gauhati Medical College and Hospital, Guwahati, Assam, India
3 Department of Nephrology, Gauhati Medical College and Hospital, Guwahati, Assam, India
 

Background: Cardiovascular abnormalities are commonly encountered in patients with chronic kidney disease (CKD) or end stage renal disease (ESRD) and these include left ventricular hypertrophy (LVH), left ventricular dilatation, and left ventricular systolic and diastolic dysfunction. Uremic cardiomyopathy is thought to be the pathological cardiac hypertrophy, indicating the influence of impaired renal function on the myocardium. Cardiovascular complications lead in all causes of mortality among patients with CKD, accounting for approximately 50% of deaths. Method: It was a hospital based study conducted from March 2014 to March 2015 in Guwahati Medical College where CKD patients were evaluated for presence of any cardiovascular morbidity. Results: Cardiomegaly on chest x-ray was present in 64% of the patients. Electrocardiography and 2D echocardiography of patients revealed LVH in76% and 84% of patients. Left ventricular systolic dysfunction (LVSD) was found in 52 % of patient of which 34 % had mild dysfunction (LVEF= 45% -54%) and 18 % had moderate dysfunction (LVEF= 35% -44%). Diastolic dysfunction was found in 54 % of patient. Conclusion: Cardiovascular complications are common in patients with chronic kidney disease, which is an important cause of morbidity and mortality in these patients and the most common morbidity found in this study was left ventricular hypertrophy.

Keywords

Chronic Kidney Disease, Cardiovascular Complications, Echocardiography.
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  • Jardine AG, McLaughlin K. Cardiovascular complications of renal disease. Heart 2001;86:459–466.
  • Nolan CR. Strategies for improving long-term survival in patients with ESRD. J Am Soc Nephrol 2005;16:S120–S127.
  • Foley RN1, Parfrey PS, Harnett JD, Kent GM, Martin CJ, Murray DC et al. Clinical and echocardiographic disease in patients starting end-stage renal disease therapy. Kidney Int 1995 Jan;47(1):186-92.
  • Ulasi LL, Arodiwe EB, Ijoma CK.Left ventricular hypertrophy in African Black patients with chronic renal failure at first evaluation. Ethn Dis 2006 Autumn; 16(4):859-64.
  • Levin Adeera. Clinical epidemiology of cardiovascular disease in chronic kidney disease prior to dialysis. Semin Dial 2003 Mar-Apr;16(2):101-5
  • Stewart GA, Gansevoort RT, Mark PB, Rooney E, McDonagh TA, Dargie HJ et al. Electrocardiographic abnormalities and uremic cardiomyopathy. Kidney Int 2005 Jan;67(1):217-26.
  • Costa Fde A, Rivera IR, Vasconcelos ML, Costa AF, Povoa RM, Bombig MT et al. Electrocardiography in the diagnosis of ventricular hypertrophy in patients with chronic renal disease.[Article in English, Portuguese, Spanish]. Arq Bras Cardiol 2009 Oct;93(4):380-6.
  • Shapira OM1, Bar-Khayim Y. ECG changes and cardiac arrhythmias in chronic renal failure patients on hemodialysis. J Electrocardiol 1992 Oct;25(4):273-9.
  • Chinwuba Ijoma, Ejikeme Arodiwe, Ifeoma Ulasi, Benedict Anisiuba. Pericardial Thickening is a Major Cardiac Complication in Patients with Chronic Kidney Disease at First Presentation. International Journal of Nephrology & Urology 2010;2(3):438-446.
  • Kamalesh M, Campbell S, Chong CK, Gipson A, Patel N, Ng C et al. Metabolic syndrome attenuates effect of chronic kidney disease on prevalence of coronary disease in men referred for stress imaging study. Clin Nephrol 2009 Mar;71(3):255-62.
  • de Lusignan, Chan T, Stevens P, O’Donoghue D, Hague N, Dzregah B, et al. Identifying patients with chronic kidney disease from general practice computer records. Fam Pract 2005;22(3):234–241.
  • Takenori Otsuka, Makoto Suzuki, Hisao Yoshikawa, Kaoru Sugi. Ventricular diastolic dysfunction in the early stage of chronic kidney disease. Journal of Cardiology 2009;54(2):199–204.
  • Parfrey PS,Foley RN, Harnett JD, Kent GM, Murray DC, Barre PE. Outcome and risk factors for left ventricular disorders in chronic uremia. Nephrol Dial Transplant 1996 Jul;11(7):1277-85.

Abstract Views: 198

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  • Clinical Study of Cardiovascular Complications in Chronic Kidney Disease Patients with Special Reference to Echocardiography

Abstract Views: 198  |  PDF Views: 82

Authors

Manjuri Sharma
Dept of Nephrology, Gauhati Medical College and Hospital, Guwahati, Assam, India
Dhiraj Das
Gauhati Medical College and Hospital, Guwahati, Assam, India
Santosh Kumar
Gauhati Medical College and Hospital, Guwahati, Assam, India
Himanab Jyoti Das
Department of Nephrology, Gauhati Medical College and Hospital, Guwahati, Assam, India

Abstract


Background: Cardiovascular abnormalities are commonly encountered in patients with chronic kidney disease (CKD) or end stage renal disease (ESRD) and these include left ventricular hypertrophy (LVH), left ventricular dilatation, and left ventricular systolic and diastolic dysfunction. Uremic cardiomyopathy is thought to be the pathological cardiac hypertrophy, indicating the influence of impaired renal function on the myocardium. Cardiovascular complications lead in all causes of mortality among patients with CKD, accounting for approximately 50% of deaths. Method: It was a hospital based study conducted from March 2014 to March 2015 in Guwahati Medical College where CKD patients were evaluated for presence of any cardiovascular morbidity. Results: Cardiomegaly on chest x-ray was present in 64% of the patients. Electrocardiography and 2D echocardiography of patients revealed LVH in76% and 84% of patients. Left ventricular systolic dysfunction (LVSD) was found in 52 % of patient of which 34 % had mild dysfunction (LVEF= 45% -54%) and 18 % had moderate dysfunction (LVEF= 35% -44%). Diastolic dysfunction was found in 54 % of patient. Conclusion: Cardiovascular complications are common in patients with chronic kidney disease, which is an important cause of morbidity and mortality in these patients and the most common morbidity found in this study was left ventricular hypertrophy.

Keywords


Chronic Kidney Disease, Cardiovascular Complications, Echocardiography.

References