International Journal of Health Research and Medico Legal Practice

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A Clinical Study of Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus


Affiliations
1 Assam Medical College, Dibrugarh, Assam, India
2 Gauhati Medical College, India
3 Tezpur Medical College, Assam, India
 

Background: Non-alcoholic fatty liver disease (NAFLD) is no longer considered a benign condition and has been identified as a common cause of chronic liver disease globally. Methods: This study was done on 199 cases of Type 2 Diabetes Mellitus with proper history, thorough clinical examination, including exact height, weight with relevant investigations. Results: The prevalence was 65.8%. Evidence of NAFLD was noted in 59.15% of male and 82.45% of female. Most of the cases were asymptomatic and hepatomegaly was the only commonest physical sign. 83.47% participants with high BMI were found to have NAFLD. The mean of fasting, post-prandial glucose levels and that of HbA1C in NAFLD, were significantly higher as compared to that with normal liver. The mean AST, ALT and ALKP levels were significantly higher as compared to the normal liver group. The ratio between AST and ALT was found to be 0.96. The mean of the total cholesterol, triglycerides and LDL were found significantly higher in the group with NAFLD, while difference in the mean value of HDL in both the groups were insignificant. Conclusion: NAFLD is more frequently encountered in poorly controlled Diabetes Mellitus, more so in presence of obesity and/or dyslipidaemia.

Keywords

Non-Alcoholic Fatty Liver Disease, Hepatic Steatosis, Transaminases, Hyperlipidamia.
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  • Prashanth M, Ganesh HK, Vima MV, John M, Bandgar T, Joshi SR et al. Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. JAPI 2009;57:205-210.

  • Suzuki A, Angulo P, Lymp J, St Sauver J, Muto A, Okada T, Lindor K. Chronological development of elevated aminotransferases in a non-alcoholic population. Hepatology 2005;41:64-71.

  • ShobhaLuxmi, Rukshana Abdul Sattar, Jamal Ara.Association of non-alcoholic fatty liver with type 2 diabetes mellitus. JLiaquatUniv Med Health Sci 2008;7(3):188-193.

  • Akber DH, Kawther AH. Non-alcoholic fatty liver disease in Saudi Type diabetic subjects attending a medical outpatient clinic. Diabetes Care 2003;26:3351-65.

  • Jayarama N, Sudha R. A study of non-alcoholic fatty liver disease in type 2 diabetes mellitus in a tertiary care centre, southern India. J of clin and diagnostic research 2012;6:243-45.

  • Lee RG. Non-alcoholic steatohepatitis: A study of 49 patients. Hum Pathol 1989;20:594-98.

  • Mofrad P, Contos MJ, Haque M, Segeant C, Fisher RA, Luketic VA et al. Clinical and histologic spectrum of NAFLD associated with normal ALT values. Hepatology 2003;37:1286-92.

  • Ludwig Y, Viaggiano TR, McGill DB, Oh BJ. Non alcoholicsteatohepatitis. Mayo Clin Proct 1980;55:434-38.

  • Neuschwander-Tetri BA, Bacon BR. NASH. Med Clin North Am 1996;80:1147-1166.

  • Gupte P, Amarapurkar D, Agal S, Baijal R, Kulshrestha P, Pramik s et al. Non alcoholic steatohepatitis in type 2 diabetes mellitus. J Gastroenterlol Hepatol 2004;19:854-8.

  • Powell EE, Cooksley WG, Hanson R, Searle J, Haliday JW. The natural history of nonalcoholic steatohepatitis: A follow up study of 42 patients upto 21 years. Hepatology 1990;11:74-80.

  • Angulo P, Keach JC, Batts KP, Lindor KD.Independent predictor of liver fibrosis in patients with non-alcoholic steatohepatitis. Hepatology 1999; 30:1356-62.

  • Williams CD, Stangel J, Asike MI, Torres DM, Shaw J, Contreras M et al. Prevalence of non-alcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle aged population utilizing ultrasound and liver biopsy: A prospective study. Gastroenterol 2011;140:124-31.


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  • A Clinical Study of Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus

Abstract Views: 259  |  PDF Views: 96

Authors

Dipen Kumar Bhattacharyya
Assam Medical College, Dibrugarh, Assam, India
Bikash Narayan Choudhury
Gauhati Medical College, India
Sanjeeb Bharadwaj
Gauhati Medical College, India
Madhumita Priyadarshini Das
Tezpur Medical College, Assam, India

Abstract


Background: Non-alcoholic fatty liver disease (NAFLD) is no longer considered a benign condition and has been identified as a common cause of chronic liver disease globally. Methods: This study was done on 199 cases of Type 2 Diabetes Mellitus with proper history, thorough clinical examination, including exact height, weight with relevant investigations. Results: The prevalence was 65.8%. Evidence of NAFLD was noted in 59.15% of male and 82.45% of female. Most of the cases were asymptomatic and hepatomegaly was the only commonest physical sign. 83.47% participants with high BMI were found to have NAFLD. The mean of fasting, post-prandial glucose levels and that of HbA1C in NAFLD, were significantly higher as compared to that with normal liver. The mean AST, ALT and ALKP levels were significantly higher as compared to the normal liver group. The ratio between AST and ALT was found to be 0.96. The mean of the total cholesterol, triglycerides and LDL were found significantly higher in the group with NAFLD, while difference in the mean value of HDL in both the groups were insignificant. Conclusion: NAFLD is more frequently encountered in poorly controlled Diabetes Mellitus, more so in presence of obesity and/or dyslipidaemia.

Keywords


Non-Alcoholic Fatty Liver Disease, Hepatic Steatosis, Transaminases, Hyperlipidamia.

References