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A Study on Pineal Gland and Melatonin in Relation to 'Severe Depressive Episode'


Affiliations
1 Gauhati Medical College, Guwahati-32, Assam, India
2 Dept. of Anatomy, Gauhati Medical College, Guwahati-32, Assam, India
 

The pineal gland or epiphysis cerebri is a small grey organ occupying a depression between the superior colliculi. The importance of the pineal gland lies in its function. The gland is a neuroendocrine gland and consists of parenchymal cells, called pinealocytes and neuroglial cells. The pinealocytes secrate a hormone called melatonin. Melatonin, 5methoxy-N-acetyltryptamin, is a neurohormone of the brain produced by pineal gland. The precursor to melatonin is serotonin, a neurotransmitter that itself is derived from the amino acid tryptophan. On the other hand 'severe depressive episode' is one of the commonest problems encountered by the doctors in the tropical countries like India, Pakistan and Bangladesh. Two particularly notable features of depression is diminished nighttime release of melatonin and abnormal sensitivity to melatonin suppression. Variation of the blood melatonin level, in the patients suffering from "severe depressive episode" with the normal individuals was seen in two groups: group "A"&group "B". In group "A" (control) subjects were selected from the medical and non medical voluntaries working at Gauhati Medical College&Hospital. In the other group "B" (case) patients attending the Psychiatry 'Out Patient Department' of Gauhati Medical College&Hospital with "severe depressive episode" were taken. The data recorded was analysed statistically using Student's T-test. P value ≤ 0.05 is considered as statistically significant. Such a study may be useful in establishing a database which may be useful in treating the patients suffering from 'severe depressive episode'.

Keywords

Pineal Gland, Melatonin, Depression.
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  • Singh V. Textbook of Clinical Neuroanatomy. Elsevier. New Delhi. 2005;1:170.

  • Bowen R. Other endocrine tissues and hormones. Hypertexts for Biomedical Sciences. 2003;2(3):169.

  • Ying-Hui Wu & Dick F. Swaab. The human pineal gland and melatonin in aging and Alzheimer's disease. J. Pineal Res. The Netherlands. 2005;2(38):145-152.

  • Snell RS. Clinical Neuroanatomy. Lippincott Williams & Wilkins, West Camden Street, Baltimore. 2006;6:247.

  • Dean WMD, Morgenthaler J & Fowkes SW. The Melatonin Chapter. Smart Drugs II. Cognitive Enhancement Research Institute. Menlo Park. California. 94026 USA. 2000;2:178.

  • Sandy KR, Anninos PA & Tsagas N. Age-related disruption of circadian rhythms. possible relationship to memory impairment and implications for therapy with magnetic fields. Int J Neurosci (England). 1991;59(4):259-62.

  • Ovanesov KB. The effect of the acute and chronic administration of melatonin on the relearning of rats in a Y maze and their sensitivity to haloperidol. Farmakol Toksikol. 1990;53(2):15-17.

  • Regelson W & Pierpaoli W. Melatonin: a rediscovered antitumor hormone, Cancer Investigation. 1987;5:379-385.

  • Piccardi G. The Chemical Basis of Medical Climatology. Thomas. Springfield Illinois. 1962;2:146

  • Phillip W & Long MD. Chapter V. The ICD-10 Classification of Mental and Behavioural Disorders World Health Organization, Geneva. 2005;119-124.

  • Webb SM & Puig-Domingo M. Role of melatonin in health and disease. Clinical Endocrinology. UK. 1995;42:221-234.

  • DeVries MW & Peeters FP. Melatonin as a therapeutic agent in the treatment of sleep disturbance in depression. J Nerv. Ment. Dis. USA. 1997;185(3):201-202.

  • Dolber OT, Hirschmann S, & Grunhaus L. Melatonin for the treatment of sleep disturbances in major depressive disorder. Am.J Psychiatry. 1998;155(8):1119-1121

  • Dalton EJ, Rotondi D, Levitan RD, Kennedy SH & Brown GM. Use of slow-release melatonin in treatment-resistant depression. J Psychiatry Neurosci. USA. 2000;25(1):48-52.

  • Kripke DF, Youngstedt SD, Rex KM, Klauber MR & Elliott JA. Melatonin excretion with affect disorders over age 60. Psychiatry. USA. 2003;118(1):47-54.

  • Brownstein MJ & Heller A. Hydroxyindole -0- methyl transferase activity: effect of sympathetic nerve activity. Science. UK. 1968;162:365.

  • Law SP. The regulation of menstrual cycle and its relationship to the moon. Acta Obstetrica et Gynecoogical Scandinavica. UK. 1986;65(1):45.

  • Thompson C, Franey C, Arendt J. & Checkley SA. A comparison of melatonin secretion in depressed patients and normal subjects. The British Journal of Psychiatry. 1988;152:260-265.

  • American Accreditation Health Care Commission. Melatonin, University of Maryland Medical Center (UMMC). University of Maryland Medical System. 22 S. Greene Street. Baltimore. 2008;2(1):43

  • Gibbons RD. & Davis JM. Consistent evidence for a biological subtype of depression characterized by low CSF monoamine levels. Acta Psychiatr Scand. 1986;74(1):8-12.


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  • A Study on Pineal Gland and Melatonin in Relation to 'Severe Depressive Episode'

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Authors

Deka Rup Sekhar
Gauhati Medical College, Guwahati-32, Assam, India
Baro Baneswar
Dept. of Anatomy, Gauhati Medical College, Guwahati-32, Assam, India

Abstract


The pineal gland or epiphysis cerebri is a small grey organ occupying a depression between the superior colliculi. The importance of the pineal gland lies in its function. The gland is a neuroendocrine gland and consists of parenchymal cells, called pinealocytes and neuroglial cells. The pinealocytes secrate a hormone called melatonin. Melatonin, 5methoxy-N-acetyltryptamin, is a neurohormone of the brain produced by pineal gland. The precursor to melatonin is serotonin, a neurotransmitter that itself is derived from the amino acid tryptophan. On the other hand 'severe depressive episode' is one of the commonest problems encountered by the doctors in the tropical countries like India, Pakistan and Bangladesh. Two particularly notable features of depression is diminished nighttime release of melatonin and abnormal sensitivity to melatonin suppression. Variation of the blood melatonin level, in the patients suffering from "severe depressive episode" with the normal individuals was seen in two groups: group "A"&group "B". In group "A" (control) subjects were selected from the medical and non medical voluntaries working at Gauhati Medical College&Hospital. In the other group "B" (case) patients attending the Psychiatry 'Out Patient Department' of Gauhati Medical College&Hospital with "severe depressive episode" were taken. The data recorded was analysed statistically using Student's T-test. P value ≤ 0.05 is considered as statistically significant. Such a study may be useful in establishing a database which may be useful in treating the patients suffering from 'severe depressive episode'.

Keywords


Pineal Gland, Melatonin, Depression.

References