International Journal of Ethnomedicine and Pharmacognosy

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Moduretic Administration in Salt-Induced Hypertension:Cardiovascular Response


Affiliations
1 Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo state, Nigeria
2 Department of Anatomy, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo state, Nigeria
3 Department of Physiology, College of Medicine, Ekiti State University, Ado-Ekiti, Ekiti State, Nigeria
 

It is a known fact that diuretics play a role in the management of hypertension; however none of the several studies done on hypertension and diuretics has reported the haemodynamic effect of moduretic on saltinduced hypertension. Aim: This study documents the haemodynamic changes in salt loading and the effect of moduretic administration on the changes. Methods: Rats of comparable weight were randomized into three groups (n=10) and allowed to acclimatized for two weeks before treatment. The control rats were administered 5 mls of distilled water. Rats were saltloaded by administering 5 ml of 5% salt solution, while the moduretic-treated rats were salt-loaded and then treated with 0.92 ml per 100g body weight (b.w) of moduretic. Treatments were per os (p.o), omni die (od) and lasted for 21 days. Results: Salt loading led to significant rise in systolic arterial pressure, diastolic arterial pressure, mean arterial pressure and heart rate, with a marginal increase in pulse pressure. The perturbing haemodynamic state caused by salt loading was improved by moduretic administration. Conclusion: The results of the study confirmed alteration of haemodynamic state by salt loading evident by increased arterial blood pressure and heart rate. The results also demonstrated that moduretic treatment is valuable in the management of salt-induced hypertension and possible associated complications.

Keywords

Moduretic, Hypertension, Salt Loading, Arterial Pressure, Weight, Haemodynamic.
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  • Moduretic Administration in Salt-Induced Hypertension:Cardiovascular Response

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Authors

W. A. Saka
Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo state, Nigeria
E. A. Ashamu
Department of Anatomy, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo state, Nigeria
O. O. Ogundipe
Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo state, Nigeria
R. E. Akhigbe
Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo state, Nigeria
F. M. Moronkeji
Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo state, Nigeria
O. O. Akintoye
Department of Physiology, College of Medicine, Ekiti State University, Ado-Ekiti, Ekiti State, Nigeria

Abstract


It is a known fact that diuretics play a role in the management of hypertension; however none of the several studies done on hypertension and diuretics has reported the haemodynamic effect of moduretic on saltinduced hypertension. Aim: This study documents the haemodynamic changes in salt loading and the effect of moduretic administration on the changes. Methods: Rats of comparable weight were randomized into three groups (n=10) and allowed to acclimatized for two weeks before treatment. The control rats were administered 5 mls of distilled water. Rats were saltloaded by administering 5 ml of 5% salt solution, while the moduretic-treated rats were salt-loaded and then treated with 0.92 ml per 100g body weight (b.w) of moduretic. Treatments were per os (p.o), omni die (od) and lasted for 21 days. Results: Salt loading led to significant rise in systolic arterial pressure, diastolic arterial pressure, mean arterial pressure and heart rate, with a marginal increase in pulse pressure. The perturbing haemodynamic state caused by salt loading was improved by moduretic administration. Conclusion: The results of the study confirmed alteration of haemodynamic state by salt loading evident by increased arterial blood pressure and heart rate. The results also demonstrated that moduretic treatment is valuable in the management of salt-induced hypertension and possible associated complications.

Keywords


Moduretic, Hypertension, Salt Loading, Arterial Pressure, Weight, Haemodynamic.