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Sanmukh, Swapnil G.
- Yersinia Phages and their Novel Proteins
Abstract Views :205 |
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Authors
Affiliations
1 Ecosystem Division, National Environmental Engineering Research Institute (NEERI), Nehru Marg, Nagpur-440020, Maharashtra, IN
1 Ecosystem Division, National Environmental Engineering Research Institute (NEERI), Nehru Marg, Nagpur-440020, Maharashtra, IN
Source
Data Mining and Knowledge Engineering, Vol 4, No 5 (2012), Pagination: 205-209Abstract
The Yersinia species are responsible for plague disease. These host bacteria are infected by their specific phages. The association of phage-host and their genetic interaction within the living bacterial cell are imparting various beneficial characteristics to its host helping it for retaining suitable characteristics for adaptation as well as evolution. The understanding of Yersinia phages can help us to know how they influence their host functional characteristics. The Yersinia phages can be understood by analyzing their hypothetical protein sequences within its genome. Our study included 102 hypothetical proteins from 6 different Yersinia phage genomes. The function predictions in 48 hypothetical proteins and 3-D structures were predicted for 5 protein sequences using PS2 server. The probable function prediction was done by using Bioinformatics web tools like CDD-BLAST, INTERPROSCAN, PFAM and COGs by searching sequence databases for the presence of orthologous enzymatic conserved domains in the hypothetical sequences. This study identified many proteins, whose roles are yet to be discovered in Yersinia phage or their bacterium. These results can be used for understanding the role of Yersinia phages in co-evolution of their hosts.Keywords
Plague, Genetic Interactions, Hypothetical Proteins, Bioinformatics Web Tools, Co-Evolution.- Insilico Function Prediction for Hypothetical Proteins in Vibrio Parahaemolyticus Chromosome II
Abstract Views :222 |
PDF Views:2
Authors
Affiliations
1 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, Nagpur-440020, IN
1 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, Nagpur-440020, IN
Source
Data Mining and Knowledge Engineering, Vol 3, No 7 (2011), Pagination: 404-432Abstract
The Vibrio parahaemolyticus is the potential food poisoning agent. The complete genome sequencing of Vibrio parahaemolyticus has been done which deciphered the presence of various gene for hypothetical proteins whose function is not yet understood. We analyzed complete genome of Vibrio parahaemolyticus for hypothetical proteins from which 458 were functionally classified into their respective protein families. Our attempt is to predict the functions of these hypothetical proteins by the application of computational methods and Bioinformatics. The probable function prediction of the hypothetical protein was done by using Bioinformatics web tools like CDD-BLAST, INTERPROSCAN, PFAM and COGs by searching sequence databases for the presence of orthologous enzymatic conserved domains in the hypothetical sequences. These study revealed presences of enzymatic functional domain in 458 uncharacterized proteins; their roles are yet to be discovered in Vibrio parahaemolyticus. These deciphered enzymatic data for hypothetical proteins can be used for the understanding of functional, structural, evolutionary and metabolic development of Vibrio parahaemolyticus and its life cycle along with their role in host evolution and pathogenicity.Keywords
Bioinformatics Web Tools, Conserved Domains, Uncharacterized Proteins, Life Cycle, Host Evolution.- Computational Approach for Structure and Functionality Search for Hypothetical Proteins in Mycobacterium Leprae
Abstract Views :194 |
PDF Views:4
Authors
Affiliations
1 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, Nehru Marg, Nagpur-440020, IN
1 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, Nehru Marg, Nagpur-440020, IN