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Nagarajan, Usha
- Crumbs Top and ‘Notch’ed Bottom in Tumours
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Authors
Affiliations
1 Department of Biochemistry and Molecular Biology, Dalhousie University, Dalhousie Medicine, New Brunswick, Saint John, NB, E2L4L5, CA
2 Chemical Biology Laboratory, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, IN
3 Department of Biochemistry, Central University of Haryana, Mahendergarh 123 029, IN
1 Department of Biochemistry and Molecular Biology, Dalhousie University, Dalhousie Medicine, New Brunswick, Saint John, NB, E2L4L5, CA
2 Chemical Biology Laboratory, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, IN
3 Department of Biochemistry, Central University of Haryana, Mahendergarh 123 029, IN
Source
Current Science, Vol 121, No 10 (2021), Pagination: 1297-1301Abstract
Membrane-bound proteins integrate and coordinate various signalling activities to maintain tissue architecture. In recent years, research updates indicate that these proteins undergo post-translational modification like glycosylation to maintain tissue integrity. Here we discuss research updates from Drosophila, about two essential membrane-bound proteins, Notch and Crumbs, that undergo such modifications to interact with each other and their implications in tumorigenesisKeywords
Epidermal-Growth-Factor Repeats, Glycosyltransferases, Membrane-Bound Proteins, Tumorigenesis, Xylosylation.Full Text
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