Refine your search
Collections
Co-Authors
Journals
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Vattikuti, Uma Maheswara Rao
- Antioxidant and Alleviatory Effects of Hydroalcholic Extract of Cauliflower Leaves against Sodium Fluoride-Induced Cardiotoxicity in Wistar Male Rats
Abstract Views :379 |
PDF Views:125
Authors
Raghavendra Mitta
1,
Ravindra Reddy Kandula
2,
Raghuveer Yadav Pulala
3,
Narasimha Jayaveera Korlakunta
4,
Uma Maheswara Rao Vattikuti
5
Affiliations
1 Department of Pharmacology, CMR College of Pharmacy, Hyderabad 501 401, IN
2 Creative Education Society’s College of Pharmacy, Kurnool 518 218, IN
3 Department of Biotechnology, Rayalaseema University, Kurnool 518 002, IN
4 Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu 515 002, IN
5 Department of Pharmacognosy, CMR College of Pharmacy, Hyderabad 501 401, IN
1 Department of Pharmacology, CMR College of Pharmacy, Hyderabad 501 401, IN
2 Creative Education Society’s College of Pharmacy, Kurnool 518 218, IN
3 Department of Biotechnology, Rayalaseema University, Kurnool 518 002, IN
4 Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu 515 002, IN
5 Department of Pharmacognosy, CMR College of Pharmacy, Hyderabad 501 401, IN
Source
Current Science, Vol 112, No 06 (2017), Pagination: 1183-1186Abstract
The objective of the present study was to explore the alleviatory effects of hydroalcoholic extract of Brassica oleracea var. botrytis (BOB) leaves against sodium fluoride (NaF)-induced cardiotoxicity. Animals served as group I (normal control), group II (toxic control) and groups III-V (treatment groups) received extract at doses of 100, 200 and 400 mg/kg body wt respectively. Group VI served as plant control and received extract at a dose of 400 mg/kg body wt. All groups, except groups I and VI, received NaF (100 ppm) through drinking water for 30 days. Results showed that administration of extract significantly minimized elevated serum levels of CK-MB and LDH, decreased cardiac lipid peroxidation, increased levels of reduced glutathione content and catalase enzyme in a dosedependent manner. The study revealed that BOB leaves show moderate antioxidant and alleviated sodium fluoride induced cardiotoxicity.Keywords
Antioxidant Activity, Cardiac Markers, Cauliflower Leaves, Hydroalcoholic Extract, Sodium Fluoride.Full Text
References
- Shivarajashankara, Y. M. et al., Effect of fluoride intoxication on lipid peroxidation and antioxidant systems in rats. Fluoride, 2001, 31, 108–113.
- Struneeka, A. et al., Fluoride interactions: from molecules to disease. Curr. Signal Transd. Ther., 2007, 2, 190–213.
- Barbier, O. et al., Molecular mechanisms of fluoride toxicity. Chem. Biol. Interact., 2010, 188, 319–333.
- Sinha, M. et al., Terminalia arjuna protects mouse hearts against sodium fluoride induced oxidative stress. J. Med. Food, 2008, 11, 733–740.
- Nabavi, S. F. et al., Protective effects of quercetin against sodium fluoride induced oxidative stress in rat’s heart. Food Funct., 2012, 3, 437–441.
- Hertog, M. G. L. et al., Dietary antioxidant flavonoids and risk of coronary heart disease, the Zutphen Elderly Study. Lancet, 1993, 342, 1007–1011.
- Lamp, W. J., Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies. Am. J. Clin. Nutr., 1999, 70, 475S–490S.
- Raghavendra, M. et al., Evaluation of acute toxicity and hepatoprotective effect of Brassica oleracea var. botrytis in experimental animals. J. Pharm. Chem., 2014, 8, 12–16.
- Naggayi, M. et al., The protective effects of aqueous extract of Carica papaya seeds in paracetamol induced nephrotoxicity in male Wistar rats. Afr. Health Sci., 2015, 15, 598–605.
- Sani, U. M., Phytochemical screening and antidiabetic effect of extracts of the seeds of Citrullus lanatus in alloxan-induced diabetic albino mice. J. Appl. Pharm. Sci., 2015, 5, 051–054.
- Gavamukulya, Y. et al., Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola). Asian Pac. J. Trop. Med., 2014, 7, S355–S363.
- Senthamilselvan, P. et al., Anti-hyperlipidemic activity of the bark extract of Terminalia arjuna in caffeine induced mice. Indian J. Appl. Res., 2015, 5, 310–313.
- Blois, M. S., Antioxidant determinations by the use of a stable free radical. Nature, 1958, 29, 1199–2000.
- Roberta, Re. et al., Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic. Biol. Med., 1999, 26, 1231–1237.
- Dinis, T. C. P. et al., Action of phenolic derivates (acetoaminophen, salycilate, and 5-aminosalycilate) as inhibitors of membrane lipid peroxidation and peroxyl radical’s scavengers. Arch. Biochem. Biophys., 1994, 315, 161–169.
- Prieto, P. et al., Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: Specific application to the determination of vitamin E. Anal. Biochem., 1999, 269, 337–341.
- Manisha, P. et al., Sida Veronicaefolia as a source of natural antioxidant. Int. J. Pharam. Sci. Drug Res., 2009, 1, 180–182.
- Zhishen, J. et al., The determination of flavonoid content in mulberry and their scavenging effects on superoxide radicals. Food Chem., 1999, 64, 555–559.
- Blainski, A. et al., Application and analysis of the Folin–Ciocalteu method for the determination of the total phenolic content from Limonium brasiliense L. Molecules, 2013, 18, 6852–6865.
- Vasant, R. A. and Narasimhacharya, A. V. R. L., Ameliorative effect of tamarind leaf on fluoride-induced metabolic alternations. Environ. Health Prev. Med., 2012, 17, 484–493.
- Niehaus, W. G. et al., Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur. J. Biochem., 1968, 6, 126–130.
- Jollow, D. J. et al., Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology, 1974, 11, 151–169.
- Greenwald, A. R., Handbook of Methods for Oxygen Radical Research, CRC Press, USA, 1985, pp. 283–284.
- Martinez-Cayuela, M., Review: oxygen free radicals and human disease. Biochemica, 1995, 77, 147–161.
- Nabavi, S., et al., Protective effect of methyl-3-o-methyl gallate against sodium fluoride-induced oxidative stress in rat cardiac tissues. Fluoride, 2012, 45, 290–296.
- Pavlova, V. et al., Antioxidant effect of Aronia melanocarpa extract after doxorubicin Treatment. Bulg. J. Agric. Sci., 2014, 20, 188–192.
- Singh, G. et al., Protective effect of Terminalia arjuna against doxorubicin induced cardiotoxicity. J. Ethnophamacol., 2008, 117, 123–129.
- Ibrahim, A. A. and El-Khalek, A. M. A., Possible protective role of calcium against fluoride induced cardio toxicities in adult male albino rats. J. Am. Sci., 2013, 9, 499–510.