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John, T. Jacob
- Covid-19: India’s Endemic Phase Heralds The Beginning of The End of The Pandemic
Abstract Views :233 |
PDF Views:84
Authors
Affiliations
1 Christian Medical College, Vellore 632 004, IN
1 Christian Medical College, Vellore 632 004, IN
Source
Current Science, Vol 121, No 12 (2021), Pagination: 1519-1520Abstract
No Abstract.Keywords
No Keywords.Full Text
- Interpreting the Omicron drama
Abstract Views :126 |
PDF Views:62
Authors
Affiliations
1 formerly at Department of Clinical Virology, Christian Medical College, Vellore 632 002, India, IN
2 Thirumalai Mission Hospital, Ranipet 632 404, India, IN
3 Apollo Hospitals, Navi Mumbai 400 614, India, IN
1 formerly at Department of Clinical Virology, Christian Medical College, Vellore 632 002, India, IN
2 Thirumalai Mission Hospital, Ranipet 632 404, India, IN
3 Apollo Hospitals, Navi Mumbai 400 614, India, IN
Source
Current Science, Vol 124, No 8 (2023), Pagination: 893-898Abstract
Omicron variant of SARS-CoV-2 emerged in southern Africa in November 2021, showing more mutations on the spike protein gene than other variants, high efficiency in transmission, immune evasion, causing a mild disease, mostly upper respiratory and low mortality. Its proximate parent is unknown. We argue that its evolutionary pathway was reverse zoonosis in rodents, acquiring rodent adaptation mutations and subsequently infecting humans as zoonosis – conceptually a ‘deviant’ with antigenic shift rather than variant with antigenic drift; its pathogenesis is modified by its cell entry pathway resulting in the absence of syncytia, low virus load, sparing lungs of pneumonia and hypoxiaKeywords
Omicron variant of concern, reverse zoonosis, SARS-CoV-2.Full Text
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