Abstract Views :244 |
PDF Views:75
Authors
Affiliations
1 Department of Veterinary Medical Sciences, University of Bologna, via Tolara di Sopra 50, 40064 Ozzano Emilia (BO), IT
Source
Current Science, Vol 113, No 10 (2017), Pagination: 1820-1821
Abstract
Recently, He et al. asserted that their new data ‘definitively’ disprove the cring of the mitochondrial F1F0-ATPase as molecular identity of the permeability transition pore (PTP). The authors’ conclusion is also confirmed by the results of the calculated ionic conductance of cring lumen, which would be incompatible with the PTP channel properties. However, in my opinion, the role of calcium- activated F1F0-ATPase as an alternative functioning mode of the F1F0 complex should also be considered in events that trigger the PTP opening.
Full Text
References
- He, J., Ford, H. C., Carroll, J., Ding, S., Fearnley, I. M. and Walker, J. E., Proc. Natl. Acad. Sci. USA, 2017, 114, 3409–3414; doi:10.1073/pnas.1702357114.
- Zhou, W., Marinelli, F., Nief, C. and Faraldo-Gómez, J. D., eLife, 2017, 6; doi:10.7554/eLife.23781.
- Alavian, K. N. et al., Proc. Natl. Acad. Sci. USA, 2014, 111, 10580–10585; doi:10.1073/pnas.1401591111.
- Giorgio, V. et al., Proc. Natl. Acad. Sci. USA, 2013, 110, 5887–5892; doi: 10.1073/pnas.1217823110.
- Zoratti, M. and Szabo, I., Biochim. Biophys. Acta, 1995, 1241, 139–176.
- Nesci, S., Trombetti, F., Ventrella, V. and Pagliarani, A., J. Membr. Biol., 2015, 248, 163–169; doi:10.1007/s00232-014-9760-y.
- Nesci, S., Ventrella, V., Trombetti, F., Pirini, M. and Pagliarani, A., Biochim. Biophys. Acta, 2016, 1860, 345–353; doi:10.1016/j.bbagen.2015.11.004.
- Nesci, S., Trombetti, F., Ventrella, V., Pirini, M. and Pagliarani, A., Biochimie, 2017, 140, 73–81; doi:10.1016/j.biochi.2017.06.013.
- Casadio, R. and Melandri, B. A., J. Biol. Inorg. Chem., 1996, 1, 284–291.
- Buzhynskyy, N., Sens, P., Prima, V., Sturgis, J. N. and Scheuring, S., Biophys. J., 2007, 93, 2870–2876; doi:10.1529/biophysj.107.109728.
