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Janardhanan, Reshma
- Fish models in experimental pharmacology: on the mark or off the mark?
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Authors
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1 Department of Pharmacology, College of Pharmaceutical Sciences, Government Medical College, Thiruvananthapuram 695 011, India, IN
2 Marine Biotechnology Division, ICAR-Central Marine Fisheries Research Institute, Kochi 682 018, India, IN
3 ICAR-Central Coastal Agricultural Research Institute, Old Goa, Goa 403 402, India, IN
1 Department of Pharmacology, College of Pharmaceutical Sciences, Government Medical College, Thiruvananthapuram 695 011, India, IN
2 Marine Biotechnology Division, ICAR-Central Marine Fisheries Research Institute, Kochi 682 018, India, IN
3 ICAR-Central Coastal Agricultural Research Institute, Old Goa, Goa 403 402, India, IN
Source
Current Science, Vol 123, No 10 (2022), Pagination: 1199-1206Abstract
Fish has emerged as an alternative model organism in biomedical research for conducting experimental pharmacological and toxicological studies. As a vertebrate, it shares many conserved physiological and molecular features with humans making it a valuable model for diagnosing, investigating disease states and testing drugs to check toxicity and therapeutic activity against the target. Zebrafish and medaka are mainstream models that are widely employed in pharmaceutical research. This study aims to highlight the probability and potential of fish as an alternative model organism in biomedical research, drug discovery and development. Further, it discusses the limitations of fish models in experimental pharmacological and toxicological studies considering the changes in the residing environment, physiology, metabolism, unpredictable inter-individual variability due to diseases, variable conditioning, and interspecific and intraspecific variabilityKeywords
Drug screening, fish, model organism, phar-macology, toxicology.Full Text
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