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Pulala, Raghuveer Yadav
- Antioxidant and Alleviatory Effects of Hydroalcholic Extract of Cauliflower Leaves against Sodium Fluoride-Induced Cardiotoxicity in Wistar Male Rats
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Authors
Raghavendra Mitta
1,
Ravindra Reddy Kandula
2,
Raghuveer Yadav Pulala
3,
Narasimha Jayaveera Korlakunta
4,
Uma Maheswara Rao Vattikuti
5
Affiliations
1 Department of Pharmacology, CMR College of Pharmacy, Hyderabad 501 401, IN
2 Creative Education Society’s College of Pharmacy, Kurnool 518 218, IN
3 Department of Biotechnology, Rayalaseema University, Kurnool 518 002, IN
4 Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu 515 002, IN
5 Department of Pharmacognosy, CMR College of Pharmacy, Hyderabad 501 401, IN
1 Department of Pharmacology, CMR College of Pharmacy, Hyderabad 501 401, IN
2 Creative Education Society’s College of Pharmacy, Kurnool 518 218, IN
3 Department of Biotechnology, Rayalaseema University, Kurnool 518 002, IN
4 Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu 515 002, IN
5 Department of Pharmacognosy, CMR College of Pharmacy, Hyderabad 501 401, IN
Source
Current Science, Vol 112, No 06 (2017), Pagination: 1183-1186Abstract
The objective of the present study was to explore the alleviatory effects of hydroalcoholic extract of Brassica oleracea var. botrytis (BOB) leaves against sodium fluoride (NaF)-induced cardiotoxicity. Animals served as group I (normal control), group II (toxic control) and groups III-V (treatment groups) received extract at doses of 100, 200 and 400 mg/kg body wt respectively. Group VI served as plant control and received extract at a dose of 400 mg/kg body wt. All groups, except groups I and VI, received NaF (100 ppm) through drinking water for 30 days. Results showed that administration of extract significantly minimized elevated serum levels of CK-MB and LDH, decreased cardiac lipid peroxidation, increased levels of reduced glutathione content and catalase enzyme in a dosedependent manner. The study revealed that BOB leaves show moderate antioxidant and alleviated sodium fluoride induced cardiotoxicity.Keywords
Antioxidant Activity, Cardiac Markers, Cauliflower Leaves, Hydroalcoholic Extract, Sodium Fluoride.Full Text
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