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Gadgil, Mugdha
- Cell Culture Processes for Biopharmaceutical Manufacturing
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1 Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory, Pune 411 008, IN
1 Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory, Pune 411 008, IN
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Current Science, Vol 112, No 07 (2017), Pagination: 1478-1488Abstract
Recombinant proteins manufactured using animal cell culture processes comprise a significant fraction of biopharmaceuticals. With the expiry of patents on this class of therapeutics, there is also a significant interest in manufacture of biosimilar versions of such therapeutics. This article provides a birds-eye view of upstream process development for animal cell culture processes, with a focus on advances pertinent to the development of processes for biosimilars.Keywords
Biopharmaceutical, CHO, Cell Line Development, Glycosylation, Monoclonal Antibody.References
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