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Mojiang mine, RaTG13, miners’ disease and related samples remain essential clues in the origin SARS-CoV-2


Affiliations
1 Bioenergy Group (former Microbial Sciences Division), MACS Agharkar Research Institute, Pune 411 004, India
2 BAIF Development Research Foundation, Central Research Station, Pune 412 202, India
 

We had published an article about the link between the Mojiang mineshaft, RaTG13, and the miners’ disease (2012), Yunnan, China which has gained a lot of attention in the question on the origin of the COVID-19. The miners’ pneumonia resembled COVID-19 in many aspects on retrospective analysis. Recently, Frutos et al. reported that the miners did not have SARS-CoV-2 infection, and hence they tried to debunk the laboratory origin of the coronavirus. In the present article, we indicate the flaws in the interpretation and analysis of Frutos et al. We also discuss how Wuhan Institute of Virology (WIV), China, shared the information about the mine, miners and RaTG13 in an incomplete and delayed manner. None of the samples have been shared with the international community so far. Many of the journalists’ attempts to visit the mineshaft were in vain, as they were not allowed to reach the site. We also discuss why all the information related to the Mojiang mine samples, details of experiments done on these and sequences of all the SARS-like viruses would be crucial for the investigation on the origins of SARS-COV-2

Keywords

Clues, COVID-19, miners’ disease, origin, SARS-CoV-2
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  • Adidi, P., Bahulikar, R. and Butler, C., Call for a comprehensive investigation of the origin of SARS-CoV-2, if possible with Chinese government participation. 2021; doi:10.13140/RG.2.2.21927.27042/1.

  • Bloom, J. D. et al., Investigate the origins of COVID-19. Science, 2021, 372(6543), 694–694. doi:10.1126/science.abj0016%JScience.

  • Helden, J. V. et al., An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2. Lancet, 2021, 398(10309), 1402–1404.

  • Latinne, A. et al., Origin and cross-species transmission of bat coronaviruses in China. Nature Commun., 2020, 11(4235).

  • Rahalkar, M. C. and Bahulikar, R. A., Understanding the origin of ‘BatCoVRaTG13’, a virus closest to SARS-CoV-2. Preprints 2020, 2020050322 (https://www.preprints.org/manuscript/202005.0322/v2).

  • Rahalkar, M. C. and Bahulikar, R. A., Lethal pneumonia cases in Mojiang miners (2012) and the mineshaft could provide important clues to the origin of SARS-CoV-2. Front. Public Health, 2020, 8(638); doi:10.3389/fpubh.2020.581569.

  • Frutos, R., Javelle, E., Barberot, C., Gavotte, L., Tissot-Dupont, H. and Devaux, C. A., Origin of COVID-19: dismissing the Mojiang mine theory and the laboratory accident narrative. Environ. Res., 2021, 204, Part B, March 2022, 112141, 1–5, EPub: 28 September 2021.

  • Alex, S., Commentary: lethal pneumonia cases in Mojiang miners (2012) and the mineshaft could provide important clues to the origin of SARS-CoV-2. Front. Public Health, 2021; doi:10.3389/ fpubh.2021.702199.

  • Zhu, J. et al., Clinical characteristics of 3062 COVID-19 patients: a meta-analysis. J. Med. Virol., 2020, 92(10), 1902–1914; doi:10.1002/jmv.25884.

  • Huang, C. et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 2020, 395(10223), 497–506; doi:10.1016/S0140-6736(20)30183-5.

  • Kwee, T. C. and Kwee, R. M., Chest CT in COVID-19: what the radiologist needs to know. RadioGraphics, 2020, 40, 1848–1865; doi:https://doi.org/10.1148/rg.2020200159.

  • Valette, X., Cheyron, D. D. and Goursaud, S., Mediastinal lymphadenopathy in patients with severe COVID-19. Lancet, 2020, 20(11), 1230.

  • Zhan, N. et al., Clinical characteristics of COVID-19 complicated with pleural effusion. BMC Infect. Dis., 2021, 21(176), 1–10.

  • Huang, C., Novel virus discovery in bat and the exploration of receptor of bat coronavirus HKU9, Ph.D. thesis, National Institute for Viral Disease Control and Prevention, Beijing, China, 2016.

  • Vilar, V., 2021 (Documentary); https://www.francetvinfo.fr/sante/ maladie/coronavirus/video-coronavirus-le-mystere-des-origines_ 4328629.html

  • Xu, L., The analysis of 6 patients with severe pneumonia caused by unknown viruses. Master’s original thesis in Chinese language, Kunming Medical University, China, 2013.

  • Zhou, P. et al., Addendum: a pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 2020, 588; https://doi.org/10.1038/s41586-020-2951-z.

  • Zhou, P. et al., A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 2020, 579(7798), 270–273; doi:10.1038/s41586-020-2012-7.

  • Ge, X. Y. et al., Coexistence of multiple coronaviruses in several bat colonies in an abandoned mineshaft. Virol. Sin., 2016, 31(1), 31–40; doi:10.1007/s12250-016-3713-9.

  • Guo, H. et al., Identification of a novel lineage of bat SARSrelated coronaviruses that use bat ACE2 receptor. Emerg. Microb. Infect., 2021, 10, 1507–1513.

  • Yu, P., Geographic evolution of bat SARS-related coronaviruses. Master’s thesis, Chinese Academy of Sciences, 2019.

  • Vineis, P. and Salmaso, S., The origin of SARS-CoV-2: why it matters? Front. Public Health, 2021, 9, 719914; doi:10.3389/fpubh.2021.719914.

  • Kang, D., Cheng, M. and McNeil, S., China clamps down in hidden hunt for coronavirus origins, 2020; https://apnews.com/article/united-nations-coronavirus-pandemic-china-only-on-ap-bats-24fbadc58cee3a40bca2ddf7a14d2955 (accessed on 17 January 2022).

  • Sudworth, J., Covid: Wuhan scientist would ‘welcome’ visit probing lab leak theory, 2020; https://www.bbc.com/news/world-asiachina-55364445 (accessed on 17 January 2022).

  • Page, J., McKay, B. and Hinshaw, D., The Wuhan lab leak question: a disused Chinese mine takes center stage, 2021; https://www.wsj.com/articles/wuhan-lab-leak-question-chinese-mine-covid-pandemic-11621871125 (accessed on 17 January 2022).

  • Anon, Bostickson, B. and Demaneuf, G., An investigation into the WIV databases that were taken offline, 2021; doi:10.13140/RG. 2.2.28029.08160.

  • Hu, B. et al., Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus. PLoS Pathog., 2017, 13(11), e1006698. doi:10.1371/journal.ppat.1006698.


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  • Mojiang mine, RaTG13, miners’ disease and related samples remain essential clues in the origin SARS-CoV-2

Abstract Views: 180  |  PDF Views: 81

Authors

Monali C. Rahalkar
Bioenergy Group (former Microbial Sciences Division), MACS Agharkar Research Institute, Pune 411 004, India
Rahul A. Bahulikar
BAIF Development Research Foundation, Central Research Station, Pune 412 202, India

Abstract


We had published an article about the link between the Mojiang mineshaft, RaTG13, and the miners’ disease (2012), Yunnan, China which has gained a lot of attention in the question on the origin of the COVID-19. The miners’ pneumonia resembled COVID-19 in many aspects on retrospective analysis. Recently, Frutos et al. reported that the miners did not have SARS-CoV-2 infection, and hence they tried to debunk the laboratory origin of the coronavirus. In the present article, we indicate the flaws in the interpretation and analysis of Frutos et al. We also discuss how Wuhan Institute of Virology (WIV), China, shared the information about the mine, miners and RaTG13 in an incomplete and delayed manner. None of the samples have been shared with the international community so far. Many of the journalists’ attempts to visit the mineshaft were in vain, as they were not allowed to reach the site. We also discuss why all the information related to the Mojiang mine samples, details of experiments done on these and sequences of all the SARS-like viruses would be crucial for the investigation on the origins of SARS-COV-2

Keywords


Clues, COVID-19, miners’ disease, origin, SARS-CoV-2

References





DOI: https://doi.org/10.18520/cs%2Fv122%2Fi3%2F247-250