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Can Peptide Nucleic Acid be the Future Substitute for Antibiotics?


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1 Department of Biotechnology, Royal Global University, Guwahati 781 035, India
 

With the emergence of growing antibiotic resistance among microbes because of habitual use of antibiotics, there is an urgent need to develop appropriate and economical substitutes for antibiotics. Antimicrobial resistance (AMR) threatens the conventional method of treatment and prevention of a wide range of multidrug-resistant (MDR) microbes which include bacteria, parasites, fungi, etc. AMR is gradually establishing itself as a serious threat to global public health which requires immediate attention from the scientific community across the globe. According to a report of the World Health Organization (WHO), in 2016 alone, approximately 500,000 people developed MDR tuberculosis worldwide and it also expected that such growing antibiotic resistance will make the fight against HIV and malaria more complicated soon1.
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  • https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance (accessed on 26 September 2019).
  • Montazersaheb, S., Hejazi, M. S. and Charoudeh, H. N., Adv. Pharm. Bull., 2018, 8(4), 551–563.
  • Hansen, A. M., Bonke, G., Larsen, C. J., Yavari, N., Nielsen, P. E. and Franzyk, H., Bioconjugate Chem., 2016, 274, 863–867.
  • Lee, H. T., Kim, S. K. and Yoon, J. W., J. Microbiol., 2019, 57(6), 423–430.
  • Otsuka, T. et al., J. Antimicrob. Chemother., 2017, 72, 137–144.
  • Ghosal, A. and Nielsen, P. E., Nucleic Acid Ther., 2012, 22(5), 323–334.
  • Quijano, E., Bahal, R., Ricciardi, A., Saltzman, W. M. and Glazer, P. M., Yale J. Biol. Med., 2017, 90, 583–598.
  • Pellestor, F. and Paulasova, P., Eur. J. Human Genet., 2004, 12, 694–700.

Abstract Views: 269

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  • Can Peptide Nucleic Acid be the Future Substitute for Antibiotics?

Abstract Views: 269  |  PDF Views: 78

Authors

Rupesh Kumar
Department of Biotechnology, Royal Global University, Guwahati 781 035, India
Bhaskarjyoti Gogoi
Department of Biotechnology, Royal Global University, Guwahati 781 035, India
Debajit Borah
Department of Biotechnology, Royal Global University, Guwahati 781 035, India

Abstract


With the emergence of growing antibiotic resistance among microbes because of habitual use of antibiotics, there is an urgent need to develop appropriate and economical substitutes for antibiotics. Antimicrobial resistance (AMR) threatens the conventional method of treatment and prevention of a wide range of multidrug-resistant (MDR) microbes which include bacteria, parasites, fungi, etc. AMR is gradually establishing itself as a serious threat to global public health which requires immediate attention from the scientific community across the globe. According to a report of the World Health Organization (WHO), in 2016 alone, approximately 500,000 people developed MDR tuberculosis worldwide and it also expected that such growing antibiotic resistance will make the fight against HIV and malaria more complicated soon1.

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DOI: https://doi.org/10.18520/cs%2Fv117%2Fi11%2F1766-1767