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Biogenic Silver Nanoparticles Embedded Polyvinyl Alcohol Nanofibrous Scaffolds Avert Tumour and Bacterial Growth


Affiliations
1 Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram 695 019, India
2 Chemical Sciences and Technology Division, Organic Chemistry Section, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695 019, India
 

This communication describes a carefully designed strategy which blends biogenic silver nanoparticles with PVA scaffolds to fabricate SNP@PVA electrospun scaffolds with admirable physico-chemical properties. The hybrid scaffold demonstrated cyto-compatibility and hemo-compatibility with no adverse effects on the surrounding cells, as demonstrated by multiple assays. The growth of cancer cells was greatly prevented by SNP@PVA scaffolds, while allowing growth of normal cells. The outstanding antimicrobial features of the scaffold can be attributed to the presence of silver na-noparticles and proves the use of SNP@PVA for bio-medical applications.

Keywords

Cancer Cells, Electrospinning, Nanofibrous Scaffold, Polyvinyl Alcohol, Silver Nanoparticles.
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  • Biogenic Silver Nanoparticles Embedded Polyvinyl Alcohol Nanofibrous Scaffolds Avert Tumour and Bacterial Growth

Abstract Views: 217  |  PDF Views: 74

Authors

G. U. Preethi
Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram 695 019, India
B. S. Unnikrishnan
Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram 695 019, India
Manu M. Joseph
Chemical Sciences and Technology Division, Organic Chemistry Section, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695 019, India
R. Shiji
Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram 695 019, India
T. T. Sreelekha
Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram 695 019, India

Abstract


This communication describes a carefully designed strategy which blends biogenic silver nanoparticles with PVA scaffolds to fabricate SNP@PVA electrospun scaffolds with admirable physico-chemical properties. The hybrid scaffold demonstrated cyto-compatibility and hemo-compatibility with no adverse effects on the surrounding cells, as demonstrated by multiple assays. The growth of cancer cells was greatly prevented by SNP@PVA scaffolds, while allowing growth of normal cells. The outstanding antimicrobial features of the scaffold can be attributed to the presence of silver na-noparticles and proves the use of SNP@PVA for bio-medical applications.

Keywords


Cancer Cells, Electrospinning, Nanofibrous Scaffold, Polyvinyl Alcohol, Silver Nanoparticles.

References





DOI: https://doi.org/10.18520/cs%2Fv116%2Fi10%2F1735-1741