Current Science

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In this study, Chromobacterium violaceum was subjected to sonic (100–2000 Hz) stimulation. Sound waves of 300 Hz frequency promoted bulk production of the quorum-regulated pigment, violacein. Whole transcriptome analysis indicated that a total of 342 genes (i.e. 4.63% of the whole genome) were significantly upregulated in the sonic stimulated culture. Enhanced violacein production in the sound-stimulated culture seems to have stemmed from enhanced expression of the genes involved in pentose phosphate pathway, resulting in an increased availability of erythrose-4-phosphate to be used in the synthesis of tryptophan – the precursor of violacein synthesis. This study is a good demonstration of the ability of sound waves to alter bacterial metabolism.

Keywords

Altered Gene Expression, Chromobacterium violaceum, Sonic Stimulation, Violacein.
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