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Synbiotics Prevent Neonatal Sepsis in Rural India


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1 2380, Sector 28, Faridabad, India
 

Neonatal sepsis is one of the primary causes of 2.7 million neonatal deaths every year followed by preterm birth. Although large-scale statistics is not available, India contributes to a major portion of this disease burden. Sepsis refers to culture-confirmed bacterial infections; however, in developing countries it primarily refers to possible severe bacterial infection (pSBI). Several conditions are clubbed together as ‘bacterial infection’ and treated with antibiotics. While preterm birth is the most common cause of death (41%) during early neonatal period (0–6 days), sepsis (37%) is the most common cause during late neonatal period (7–27 days).
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  • Lawn, J. E. et al., Lancet, 2003, 384, 189–205.

  • Zaidi, A. K. M., Thaver, D., Ali, S. A. and Khan, T. A., Pediatr. Infect. Dis. J., 2009, 28, S10–S18.

  • Edmond, K. and Zaidi, A., PLoS Med., 2010, 7, e1000213.

  • Calvano, S. E. et al., Nature, 2005, 437, 1032.

  • The INIS Collaborative Group, N. Engl. J. Med., 2011, 365, 1201–1211.

  • Niewiesk, S., Front. Immunol., 2014, 5, 446.

  • Levy, O., Nature Rev. Immunol., 2007, 7, 379–390.

  • Mullany, L. C., Darmstadt, G. L. and Tielsch, J. M., Pediatr. Infect. Dis. J., 2006, 25, 665–675.

  • Darmstadt, G. L. et al., Lancet, 2005, 365, 1039–1045.

  • Ashraf, R. N. et al., Arch. Dis. Child., 1991, 66, 488–490.

  • Patel, A. L. et al., J. Perinatol., 2013, 33, 514–519.

  • Panigrahi, P. et al., Nature, 2017, 548, 407–412.

  • Panigrahi, P. et al., J. Perinatol., 2017, 37, 911–921.

  • Khailova, L., Baird, C. H., Rush, A. A., McNamee, E. N. and Wischmeyer, P. E., Shock, 2013, 40, 496–503.

  • Dilli, D. et al., J. Pediatr., 2015, 166, 545–551.

  • Dilli, D. et al., Pediatrics, 2013, 132, e932–e938.

  • Nandini, L. P., Biswal, N., Adhisivam, B., Mandal, J., Bhat, B. V. and Mathai, B., J. Matern. Neonatal Med., 2016, 29, 821–825.

  • Jacobs, S. E. et al., Pediatrics, 2013, 132, 1055–1062.

  • Costeloe, K., Hardy, P., Juszczak, E., Wilks, M. and Millar, M. R., Lancet, 2016, 387, 649–660.

  • Sinha, A. et al., BMJ Open, 2015, 5, e006564.


Abstract Views: 242

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  • Synbiotics Prevent Neonatal Sepsis in Rural India

Abstract Views: 242  |  PDF Views: 68

Authors

P. Surat Saravanan
2380, Sector 28, Faridabad, India

Abstract


Neonatal sepsis is one of the primary causes of 2.7 million neonatal deaths every year followed by preterm birth. Although large-scale statistics is not available, India contributes to a major portion of this disease burden. Sepsis refers to culture-confirmed bacterial infections; however, in developing countries it primarily refers to possible severe bacterial infection (pSBI). Several conditions are clubbed together as ‘bacterial infection’ and treated with antibiotics. While preterm birth is the most common cause of death (41%) during early neonatal period (0–6 days), sepsis (37%) is the most common cause during late neonatal period (7–27 days).

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DOI: https://doi.org/10.18520/cs%2Fv114%2Fi04%2F719-720