Asian Journal of Research in Pharmaceutical Sciences

Swati S. Talokar ¹, Rohan R. Vakhariya ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon Tal Walwa, Dist Sangli, Maharashtra, IN

Abstract

Technology transfer is a critical and integral part of drug development process. This path for is dependent on completion of technology transfer to the product site at an affordable cost. The purpose of this review article is to discuss various aspects of technology transfer. This article highlights the goals, importance, facets and various models associated with technology transfer. This article also discuss some of examples of technology transfer in India as well as in global market.

Keywords

Technology Transfer, Facets, Model.

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Rohan R. Vakhariya ¹, Swati S. Talokar ¹, V. R. Salunkhe ¹, C. S. Magdum ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, IN

Abstract

The present research work support preformulation, formulation, development and optimization of solid lipid nanoparticles containing simvastatin as an antihyperlipidemic drug. The different batches of formulation were obtained using simvastatin as active pharmaceutical ingredient, stearic acid as the source of lipid and β - cyclodextrin as a polymer. Solid lipid nanoparticles of simvastatin were prepared by precipitation method. The prepared formulations were evaluated for various parameters like Particle size, Percentage entrapment efficiency, Measurement of Zeta Potential, FTIR, in-vitro release study. The result was found to be within standard limit. FTIR study reports indicated that there was no interaction between Simvastatin and other excipients. Motic microscope shown that the nanoparticles size ranges from 100-550nm. Percent entrapment efficiency was between 61.40% - 92.30%. Based on the resultants of the entrapment and particle size of nanoparticles, formulation S6 was observed to be optimized formulation. The optimized formulation exhibited 63.75% cumulative drug release after 24 h. The optimized batch shows mean of zeta potential at -44.0 mV.

Keywords

Antihyperlipidemic Drug, β–Cyclodextrin, Entrapment Efficiency, Zeta Potential, Motic Microscope.

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