A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Aher, Smita S.
- Mucoadhesive Formulations for Buccal Mucosa
Authors
1 Department of Pharmaceutical Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 3 (2016), Pagination: 146-152Abstract
Mucoadhesion could be a field of current interest within the style of drug delivery systems. Mucoadhesive drug delivery system prolongs the continuance of the indefinite quantity kind at the positioning of application or absorption associate degreed facilitates an intimate contact of the indefinite quantity kind with the underline absorption surface and so contributes to improved and higher therapeutic performance of the drug. In recent years several such mucoadhesive drug delivery systems are developed for oral, buccal, nasal, body part and canal routes for each general and native effects.
Issues like high first-pass metabolism and drug degradation within the canal surroundings is circumvented by administering the drug via the buccal route. Moreover, speedy onset of action is achieved relative to the oral route and therefore the formulation is removed if medical care is needed to be out of print. It’s additionally attainable to administer medication to patients UN agency unconscious and fewer co-operative. To forestall accidental swallowing of medicine adhesive tissue layer indefinite quantity forms were advised for oral delivery, including adhesive tablets, adhesive gels, adhesive patches and plenty of alternative indefinite quantity forms with numerous combos of polymers, absorption enhancers. Additionally to the current, studies are conducted on the event of controlled or slow unharness delivery systems for general and native medical care of diseases.
Keywords
Buccal Region, Mucoadhesive, 1st Pass Metabolism.- Fast Dissolving Sublingual Film
Authors
1 Department of Quality Assurance Technique, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 3 (2016), Pagination: 153-160Abstract
Orally fast dissolving films are an emerging technology with fast onset of activity and improved patient compliance. It enhances the viability of API's and gives better medication use. These formulations are suitable for cold, allergy rhinitis, asthma attacks, CNS issue where fast onset of activity is needed for quicker help. The sublingual course of medication organization is extremely compelling following the medication retained through the sublingual veins by passes hepatic first pass metabolic procedure and also gives a better bioavailability. The present article outlines the definition viewpoints, manufacturing methods like solvent casting method, evaluation parameters and applications of fast dissolving films by sublingual route It has been estimated that approximately 84% of all sales of the top selling commercially available products are delivered via the oral route. Thin film drug delivery has come forward as an advanced alternative to the traditional tablets, capsules and liquids frequently associated with prescription and OTC medications. Similar in size, shape, and thickness to a postage stamp, thin film strips are classically designed for oral administration, with the user placing the strip on or under the tongue(sublingual)or along the inside of the cheeks(buccal).These drug delivery options allows the medication to bypass the first pass metabolism thereby making the medication further available. As the strip dissolves, the drug can enter the blood stream enterically, buccally or sublingually. The permeation is superior with sublingual than buccal than palatal region.Keywords
Fast Dissolving Drug Delivery, Oral Strips, Sublingual Film, Mouth Dissolve.- Formulation and Evaluation of Controlled Release Matrix Tablet of Albuterol Sulphate
Authors
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 4 (2016), Pagination: 223-229Abstract
A sustained release matrix formulation for Albuterol Sulphate was designed and developed to achieve a 12 h release profile. Using HPMC K15M and HPMC K100M as an inert matrix forming agent to control the release of Albuterol Sulphate. The matrix tablets for these formulations were prepared by direct compression and their in-vitro release tests were carried out for a period of 12 hours using USP dissolution test apparatus (type II Paddle) at 37±0.5°C and 50 rpm speed. A 32 full factorial design was used for optimization by taking the concentration of HPMC K15M (X1) and HPMC K100M (X2) were selected as independent variables, whereas initial release at the (Y1, % drug release), (Y2, % drug Content) the concentration of Were chosen as dependent variables. The optimized formulation F9 follows Higuchi model and Korsemeyer - Pappas release kinetics with non- Fickian diffusion mechanism. From the study, it was concluded that the release of Albuterol Sulphate can be effectively controlled using combination of HPMC K15M, HPMC K 100M and Carbopol 940.Keywords
Albuterol Sulphate, Gelucire43/01, Melt Method, Direct Compression Method, Factorial Design.- Nanosuspension:An Overview
Authors
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN