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Khandare, Shubham
- Thiocolchicoside: An Updated Review
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1 Department of Pharmaceutics, P. R. Pote College of Pharmacy, Pote Patil Road, Amravati. 444602., IN
1 Department of Pharmaceutics, P. R. Pote College of Pharmacy, Pote Patil Road, Amravati. 444602., IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 12, No 03 (2022), Pagination: 213-218Abstract
Thiocolchicoside is a most common used muscle relaxant in the case of treating acute painful muscle spasms. It has a selective affinity for the inhibitory gamma-amino butyric acid and glycinergic receptors, although, the proper pathway of the muscle relaxation is unknown till the date. This drug should be strictly prohibited in the patients causing seizures. The recent studies done by the European medicines agency says that it causes aneuploidy which leads to use of the drug for limited time period which was earlier considered safe. Aneuploidy is a common chromosome disorder occurring in the humans, which leads to genetic cause of miscarriage, congenital birth defects and reduced fertility in men. During pregnancy, in breastfeeding and in children below 16 years, Thiocolchicoside is contraindicated.Keywords
Thiocolchicoside, Muscle Spasm, Seizures, Aneuploidy.
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