Asian Journal of Research in Pharmaceutical Sciences

Pooja M. Nikam ¹, S. B. Gondkar ¹, R. B. Saudagar ¹

Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik- 422003, IN

Abstract

The Overall prevalence rate for CNS pathology has demonstrated that approximately 1.5 billion people under going from disorders of central nervous system. The most distressing fact about delivery of drugs to the CNS is the presence of blood brain barrier that have a tendency to impair the drug distribution and denotes the major impediment for the development of CNS drugs. Neuropeptides and many drugs which are hydrophilic in nature, possibly will encompass the intricacy while passing the blood brain barrier. The net amount of delivered drug (medicinal agent) and its capability to gain access to the pertinent target sites are the main considering points for CNS drug development. In order to distribute the drugs into the CNS via passing the blood brain barrier, many new emerging approaches have been developed for example Magnetic drug targeting, chemical delivery Systems, Drug carrier systems (antibodies, liposomes or Nanoparticles). Among drug carrier system, Nanoparticles exhibit an impressive attention in the field of targeted drug delivery system because of possessing solid colloidal particles with a size range between 1- 1000nm. Gradual drug release reduced peripheral toxicity and potential totarget specific brain sites by crossing the blood brain barrier are major benefits contributed by Nanoparticles. In this review we will discuss the methodologies for targeting the brain site.

Keywords

Brain Barrier, Drug Delivery to Brain, Nanotechnology, Colloidal Drug Carriers.

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T. V. Kadam ¹, A. B. Darekar ¹, S. B. Gondkar ², R. B. Saudagar ³

Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

In these studies describes a simple, accurate, precise and cost effective UV-visible spectrophotometric method for the estimation of Azelaic acid in pure and pharmaceutical formulations. The method is based on the measurement of absorbance of Azelaic acid solution in Phosphate buffer pH 6.8 at 204nm in the wavelength range of 200-400nm. The method obeys Beer's Lambert's law in the selected concentration range10-50 μg/ml in selected media. The slope, intercept and correlation coefficient were also calculated. Results of percentage recovery study shows that the method was not affected by the presence of common excipients in tablets. The parameters like linearity, precision, accuracy, sensitivity study i.e. limit of detection and limit of quantitation were studied according to International Conference on Harmonization (ICH) guidelines. The developed method was validated in terms of accuracy, precision, linearity, limit of detection and limit of quantitation which proves suitability of proposed method for routine estimation of Azelaic acid in pure and pharmaceutical formulations.

Keywords

UV-Visible Spectrophotometer, Method Development, Azelaic Acid.

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