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Parmar, Ramesh B.
- Design Formulation and Evaluation of Reservoir Type Controlled Released Moxifloxacin Hydrochloride Ocular Insert
Abstract Views :773 |
PDF Views:81
Authors
Affiliations
1 S. J. Thakkar Pharmacy College, Opp NRI bungalow, Avadh Club Road, Munjka, Kalawad Road, Rajkot, IN
2 Matushree V B Manvar Pharmacy College, Dumiyani, Upleta, Rajkot, IN
1 S. J. Thakkar Pharmacy College, Opp NRI bungalow, Avadh Club Road, Munjka, Kalawad Road, Rajkot, IN
2 Matushree V B Manvar Pharmacy College, Dumiyani, Upleta, Rajkot, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 1 (2013), Pagination: 19-24Abstract
The present studies were mainly focus to developed ocular controlled release formulation of Moxifloxacin Hydrochloride. Reservoir type of ocular insert was developed by solvent casting method. Total nine formulations was developed using different ratio of Eudragit RS 100 and Eudragit RL100 in combination as a rate controlling membrane and reservoir was prepared by using sodium CMC. All the prepared formulation were subjected for evaluation of physicochemical parameter like thickness, weight variation, percentage moisture absorption, percentage moisture loss, surface pH, sterility, drug content and anti-microbial activity. Evaluated results were shown that all the prepared formulation was suitable for patient compliance. In-vitro release study was carried out by using commercial semipermeable membrane with the help of modified standard cylindrical tube method and best formulation F7 found 98.21 % at the end of 24 hrs. Formulated ocular inserts also passed the test for sterility. The above in vitro release studies revealed that the best ocular inserts formulation followed near to zero-order release kinetics. Higuchi’s plot and Peppa’s plot revealed that the mechanism of drug release involved in all the formulations was super case II transport diffusion. The antimicrobial study was shown that formulation was able to inhibit the microbial growth for extended period of time. The controlled release ocular insert was more suitable as compared to conventional dosage form.Keywords
Reservoir Drug Delivery System, Ocular Insert, Moxifloxacin Hydrochloride, Eudragit RS100, Eudragit RL 100.
References
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- Enhancement of Solubility and Dissolution Rate of Poorly Water Soluble Drug by Using Modified Guar Gum
Abstract Views :461 |
PDF Views:82
Authors
Vipul V. Jambukiya
1,
Ramesh B. Parmar
1,
Ashvin V. Dudhrejiya
1,
H. M. Tank
1,
Vipul D. Limbachiya
1
Affiliations
1 Dept. of Pharmaceutics, Saurashtra University, Rajkot -360005, IN
1 Dept. of Pharmaceutics, Saurashtra University, Rajkot -360005, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 1 (2013), Pagination: 25-30Abstract
Introduction: The increasing interest of the technology of dosage form with natural biopolymers has become the reason for undertaking present investigation on the possibility of guar gum application in the preparation of an oral solid dosage form of a poorly water soluble drug.
Method: Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC and FT-IR study.
Results: The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies using USP XXIII Dissolution apparatus. The rank order of solubility and dissolution study was IBU < grounded IBU < Physical mixture of IBU and GG < Physical mixture of IBU and MGG < Co-grinding mixture of IBU and GG < Co-grinding mixture of IBU and MGG.
Conclusion: The results of present investigation indicated that co-grinding mixture of ibuprofen with modified guar gum could be useful in developing an oral dosage form with improved dissolution and oral bioavailability of poorly water soluble drug.
Keywords
Guar Gum, Modified Guar Gum, Dissolution Rate Enhancement, Poorly Soluble Drug.References
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