Asian Journal of Research in Pharmaceutical Sciences

K. Solanki Divya ¹, Hasumati Raj ¹, Prajapati Neelam ¹

Affiliations
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, IN

Abstract

This review article presents the pharmacology of combined treatment of Aripiprazole and Escitalopram oxalate in treatment of Major Depressive Disorders. Aripiprazole is anti psychotic agent. Escitalopram Oxalate is also an antidepressant agent (Selective Serotonin Reuptake Inhibitor). Aripiprazole's antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex. Antagonism at D2 receptors relieves positive symptoms while antagonism at 5HT2A receptors relieves negative symptoms of schizophrenia. Escitalopram Oxalate is selective serotonin reuptake inhibitors (SSRIs) are a group of chemically diverse antidepressant drugs that specifically inhibit serotonin reuptake. The SSRIs block the reuptake of serotonin, leading to increased concentrations of the neurotransmitter in the synaptic cleft and, ultimately, to greater postsynaptic neuronal activity. The combination of both have decrease dose and improve Depression. Combination of both the drugs were approved by us government and has been used in Major Depressive Disorders. The main objective of this review article is to provide pharmacological information of combined therapy of of Aripiprazole and Escitalopram Oxalate to researcher in development of combined dosage form of this.

Keywords

Aripiprazole, Escitalopram Oxalate, Major Depressive Disorders, Pharmacology.

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S. Sisode Pranali ¹, C. Jain Vinit ¹, Prajapati Neelam ¹

Affiliations
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist. Surat, Gujarat, IN

Abstract

This review article presents the pharmacology of combined treatment of Saxagliptin hydrochloride and Glibenclamide therapy especially in type-2 diabetes. Saxagliptin hydrochloride is anti diabetic agent (dipeptidyl peptidase-4 inhibitor). Glibenclamide is also an anti-diabetic agent. If Glibenclamide is administered as a long term treatment and also in large quantities, the condition of patient becomes worse by causing sulphonylurea failure. And also occurrence of adverse effect of weight gain and hypoglycemia. The availability of newer agents such as dipeptidyl peptidase-4 inhibitors may allow for additional therapeutic combinations to improve glycaemic control without increasing the risk of adverse effects. Combination therapy of a DPP-4 inhibitor with a sub maximal dose of a sulphonylurea represents an alternative treatment approach that may provide improved glycaemic control earlier in the disease course and allow the use of lower doses of sulphonylurea to reduce the risk for dose-related adverse events. Combination therapy mainly used to treat patient having sulphonylurea failure. The mechanism of action of Saxagliptin hydrochloride and Glibenclamide is quite different. Saxagliptin hydrochloride inhibits the dpp-4 enzyme and promotes insulin synthesis and release. While Glibenclamide stimulation of insulin release from the B2 cells of the pancreas by blocking the ATP-sensitive k+ channels. The combination of both have decrease dose and improve the glycemic control. Combination of both the drugs were approved by us government and has been used in type-2 diabetes (diabetes mellitus). The main objective of this review article is to provide pharmacological information of combined therapy of saxagliptin hydrochloride and glibenclamide to researcher in development of combined dosage form of this.

Keywords

Saxagliptin Hydrochloride, Glibenclamide, Type-2 Diabetes, Pharmacology.

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