Refine your search
Collections
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Rama Rao, N.
- Solid Dispersions-An Approach to Enhance the Dissolution Rate of Clopidogrel Bisulphate
Abstract Views :173 |
PDF Views:0
Authors
Affiliations
1 Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P, IN
1 Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 4, No 4 (2014), Pagination: 165-168Abstract
Solid dispersions are one of the techniques to improve the solubility of the poorly soluble drugs. In this technique a poorly soluble drug is dispersed in the highly soluble hydrophilic matrix, two types of polymers are considered as carriers i.e., lactose, dextrose and cornstarch. Solubility is the basic step for formulation of different type of dosage forms. clopidogrel bisulphate is a BCS class II drug having low solubility and high permeability, used as ant platelet drug to inhibit blood clots in coronary artery disease, peripheral vascular disease and cerebrovascular disease. In this research article Clopidogrel bisulphate solubility has been increased by co-grinding method i.e.,one of the solid dispersion technique lactose (1:5,1:10,1:15), dextrose (1:10,1:15) cornstarch:lactose (1:10,1:15) from three different polymers cornstarch: lactose showed 99%solubility than dextrose and lactose. In-vitro dissolution studies were conducted in PH 6.8 buffer.Keywords
Clopidogrel Bisulphate, Solid Dispersions, Antiplatelet, Cornstarch, Lactose.- Rectal Drug Delivery:A Promising Route for Enhancing Drug Absorption
Abstract Views :236 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034, IN
1 Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034, IN