Asian Journal of Research in Pharmaceutical Sciences

Rahul Jodh ¹, Mukund Tawar ¹, Aparna Kachewar ¹, Vishal Mahanur ¹, Yash Sureka ¹, Virendra Atole ¹

Affiliations
1 Department of Pharmacology, P. R. Pote Patil College of Pharmacy, Amravati-444604., IN

Abstract

The liver assumes a significant part in keeping up with the metabolic capacity and discharge of poisons from the body. A physical issue or liver brokenness brought about by the utilization of poisonous synthetics, over-the-top liquor and microorganisms bring about a difficult condition called hepatotoxicity. Madhuca longifolia having a place with Sapotaceae family is found to have pharmacological properties in the treatment of different disorders. Madhuca longifolia is likewise considered a therapeutic tree also, is helpful for outside application in treating skin infections, stiffness, migraine, persistent clogging, heaps, hemorrhoids, and ethno clinical properties like antibacterial, anxiolytic qualities, anticancer, hepatoprotective, antiulcer, antihyperglycemic, pain-relieving exercises, and so on. Leaves of mahua are utilized in the treatment of dermatitis, wound mending, anti-burn, bone crack, anthelminthic, emollient, skin illness, stiffness, and cerebral pain. The flowers are used as a tonic, pain-relieving, and diuretic; bark for an ailment, persistent bronchitis, and diabetes mellitus and leaves as an expectorant and constant bronchitis and Cushing's sickness. In this review we make a compilation focused on the synonyms, botanical description, phytochemicals, pharmacological activity, and medicinal uses of Madhuca longifolia.

Keywords

Madhuca longifolia, Pharmacology, Anti-anxiety, Phytocompounds, Utilization.

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Rahul Jodh ¹, Mukund Tawar ¹, Aparna Kachewar ¹, Yogiraj Ingole ¹, Tejas Deshmukh ¹, Vipul Ijapure ¹

Affiliations
1 Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati., IN

Abstract

Tobramycin is another aminoglycoside anti-microbial with a wide antibacterial range in vitro, and pharmacokinetic properties like those for gentamicin. Tobramycin is more dynamic than gentamicin against Pseudomonas aeruginosa and dynamic against numerous gentamicin safe strains, yet isn't dynamic against enterobacteriaceae impervious to gentamicin. Hypothetically, tobramycin enjoys an upper hand over gentamicin against diseases brought about by P. aeruginosa, yet any benefit in clinical practice presently can't seem to be enough illustrated. Clinical involvement in tobramycin is significantly not exactly with gentamicin. While tobramycin seems to offer no unmistakable benefits over gentamicin against touchy organic entities it is shown in contamination brought about by strains of P. aeruginosa which are impervious to gentamicin, yet touchy to tobramycin. Like gentamicin, tobramycin acts synergistically with carbenicillin and the cephalosporins. The viability of the tobramycin-carbenicillin blend has been displayed in endocarditis brought about by P. aeruginosa which was lethargic to gentamicin in addition to carbenicillin. Ototoxicity and nephrotoxicity like that seen with other aminoglycosides have been experienced in helpful preliminaries with tobramycin and more extensive clinical experience is important to decide the general occurrence of these incidental effects with gentamicin and tobramycin utilized under comparable conditions. Antimicrobial movement: In relative examinations, in vitro, tobramycin is more dynamic than gentamicin against clinical separates of Pseudomonas aeruginosa. Likewise, the inhibitory file, which is the proportion between the serum fixations accomplished at common remedial portions and the base inhibitory focus, for Pseudomonas aeruginosa is higher for tobramycin than for gentamicin.

Keywords

Antibiotic, Tobramycin, Aminoglycoside, Anti-microbial, Pseudomonas aeruginosa

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Mukund Tawar ¹, Kiran Raut ¹, Reshma Chaudhari ¹, Nikita Jain ¹

Affiliations
1 Department of Pharmaceutics, P. R. Pote Patil College of Pharmacy, Amravati – 444604., IN

Abstract

Orally directed medications totally ingest just when they show reasonable dissolvability in gastric medium and such medications shows great bioavailability. The solvency and disintegration properties of medications assume a significant part during the formulation development. Greater part of the disappointments in the new medication improvement have been credited to poor water dissolvability of medication. It is widely accepted that poor water dissolvability is quite possibly the most every now and again experienced troubles in the field of pharmaceutics. Low solvency and ensuing unacceptable disintegration rate regularly bargain oral bioavailability. There are most remedial specialists used to create fundamental impacts by oral course that are the favored method of organization inferable from its few benefits and high quiet consistence contrasted with different courses. Thusly the current methodologies being utilized for BCS class II medications, along with retention enhancers, can be applied to detail class IV compound. Effervescent Assisted Fusion Technique, Solvent Evaporation method, Microemulsion, Liposomes are some imperative methodologies regularly utilized to improve the dissolvability of ineffectively water dissolvable medications. Determination of technique for solvency upgrade relies on drug qualities like dissolvability, substance nature, melting point, retention site, actual nature, pharmacokinetic conduct, etc, measurement structure necessity like tablet or capsule formulation, strength, quick or modified release. This review features the novel strategies accessible for improving solvency, disintegration and bioavailability of medications with poor fluid dissolvability.

Keywords

Solubility Enhancement, Drug Release, Nanocrystallization, BCS, Novel Techniques.

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Vedanshu Malviya ¹, Mukund Tawar ², Prashant Burange ³, Rahul Jodh ³

Affiliations
1 Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444602., IN
2 Department of Pharmaceutical Chemistry, P.R. Pote Patil College of Pharmacy, Amravati – 444602., IN
3 Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati – 444602., IN

Abstract

Resveratrol can be recognized as a best nutraceutical. Resveratrol is a novel nutraceutical in which not many details are known therefore an attempt was made to review the details which may be used for the further research. Resveratrol is known to be a polyphenol named as stilbenoid group which is a phytoalexin secreted by more than 70 plant species which is having many pharmacological activities like anticancer, anti-inflammatory, anti-ageing, neuroprotective, cardioprotective, anti-microbial and etc. This natural table top food has a lower bioavailability with lower aqueous solubility. From this review we can conclude that resveratrol is a unique complex having various properties with lots of other benefits.

Keywords

Resveratrol, Natural Phenol, Phytoalexin, Grape Skin, Stilbenoid.

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