Asian Journal of Research in Pharmaceutical Sciences

Ismail Hussain ¹, Ravikumar ², V. B. Narayanaswamy ³, Injamamul Haque ¹, Mohibul Hoque ⁴

Affiliations
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
3 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
4 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN

Abstract

Transdermal drug delivery systems are also known as patches, containing dispersed or dissolved drug with plasticizers, polymers, etc. are intended to deliver a therapeutically effective amount of drug across the skin. In the present work, Transdermal drug delivery of Risperidone were formulated in different concentration (10%, 20% and 30% ) of glycerine and polyethylene glycol 400 as plasticizer and a blend of two in different concentrations of polymers (PVPK30,HPMC,PVA and Eudragit RS 100) were formulated by solvent casting method. Drug polymer interaction study was carried out using FTIR and DSC studies. In this study the results indicates, as increase in the concentration of glycerine and Polyethylene glycol increases the diffusion rate of Risperidone patches. The physico-chemical parameters like weight variation, thickness, folding endurance. Percentage Flatness and Water vapour transmission of the Risperidone patches were evaluated. All the physico chemical parameters were found to be satisfactory. Risperidone patches formulated by using 30% glycerine 30% PEG400shows enhanced rate of diffusion than the patches prepared with 10% and 20% glycerine10% and 20% PEG400 respectively. Risperidone patches formulated with 20% glycerine 20% PEG400 had enhanced rate than the patches prepared with 10%glycerine/10% PEG400 respectively. Among polymers, combination of HPMC and Eudragit had enhanced diffusion rate than the combination of HPMC and PVPK30 in all formulations formulated by using glycerine as plasticizer. The polymers, combination of PVPK30 and Eudragit had enhanced diffusion rate than the combination of PVPK30 and PVA in all formulations formulated by using PEG400 as plasticizer. The Risperidone transdermal patches shows greater diffusion rate when formulated with higher concentration of plasticizer hence the30% of glycerine and PEG 400 had shown a values higher than 20 and 10 % glycerine and PEG 400. The kinetic study and mechanism for the diffusion of Risperidone transdermal patches obeys higuchi, peppas model. The correlation coefficient (R2) values were greater, indicating from the analysis of diffusion data as per above models. The T50 and T80 values for Risperidone patches formulated with glycerine andPEG400 are exhibited good results. The SEM films indicating uniform distribution of the drug with polymers and plasticizers.

Keywords

Transdermal Drug Delivery, Diffusion Rate, Eudragit, Risperidone, Plasticizer, HPMC.

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Monirul Islam ¹, J. Ramanjaneyulu ¹, D. Veeresh Babu ¹, Mohibul Hoque ¹, V. B. Narayana Swamy ²

Affiliations
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN

Abstract

In recent decades, it has become one of the principal pillars of a branch of science called cognitive neuroscience, an interdisciplinary link between cognitive and neuroscience. The objective of this to investigate the neuropsychological effect of a polyherbal formulation Bravobol on learning and memory processes in mice by elevated plus maze and Morris water maze model. Bravobol contains Evolvulus alsinoids (Shankhpushpi), Bacopa monnieri (Brahmi), Withania somnifera (Ashwagandha), Celastrus paniculatus (Malkangani) and Abhrak bhasma. Its effect (250, 500, and 750 mg/kg, p.o.) was tested on learning and memory processes. Activity of Bravobol on acquisition and retention was studied using elevated plus maze model (EPM) and spatial memory using Morris water maze model (MWM) in mice. The results were compared with the vehicle-treated group. Administration of Bravobol (250, 500 and 750 mg/kg, p.o) showed significant reduction in transfer latency in EPM and escape latency in MWM as compared to the control group. Bravobol may act as a memory enhancer formulation and may also be useful as a supportive adjuvant in the treatment of Alzheimers disease.

Keywords

Polyherbal Formulation, Elevated Pluz Maze, Moriss Water Maze.

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