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Panday, Manju
- A Review - Shivambu Kalpa - Various Therapeutic Uses of Urine
Authors
1 Azad Institute of Pharmacy and Research, Azadpur, Adjacent CRPF Camp, Bijnour, Lucknow UP, IN
2 Saroj Institute of Technology and Management, Ahimamau P.O. Arjunganj Sultanpur Road, Lucknow UP, IN
3 Hygia Institute of Pharmacy, Lucknow, UP, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 4, No 2 (2014), Pagination: 93-98Abstract
Human urine has strengthening and curative characteristics concerning many deficiencies. A mixture of potato and sulphur powder, mixed with heated, old urine helps against hair loss. One should rub this mixture into the scalp; this slows down loss of hair. All kinds of throat inflammation can be helped by gargling with urine to which a bit of saffron has been added. Trembling hands and knees can be helped by washing, and rubbing one's own warm urine into the skin directly after one has urinated. Drink your own water in the morning nine days together and it cures the scurvy, makes the body lightsome and cheerful. It is good against the dropsy and Jaundice, drunk as before. Wash your ears with it warm and it is good against deafness noises and nost other ailments in the ears. Wash your eyes with your own water and it cures sore eyes and clears and strengthens the sight. Wash and rub your hands with it and it take away numbness, chaps and sores and makes the joints limber. Wash any green wound with it and it is an extraordinary good thing. Wash any part that itches and it takes the itch away. More than any other method, urine therapy represents the principles of natural medicine. One's own urine is a specific medicine for anyone who is ill. It is made for him or her personally and is just right for what he or she needs at the present moment, because it changes its composition all the time.Keywords
Gargling, Scurvy.
References
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- Formulation and Evaluation of Efavirenz 600 mg Tablet
Authors
1 Azad Institute of Pharmacy and Research Azadpur, Adjacent CRPF Camp, Bijnour, Lucknow - 226 002, Uttar Pradesh, IN
2 Mangalayatan University, Beswan, Aligarh, Uttar Pradesh, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 3 (2015), Pagination: 153-167Abstract
Aim: Formulation and Evaluation of Efavirenz 600 mg Tablet.
Methodology: Accurately weighed amount of selected additive concentrates (F1, F2, F3, F4, F5, F6) representing 600 mg equivalent of drug was mixed with directly compressible excipients i.e. Croscarmellose Sodium and Sodium Starch Glycolate as superdisintegrants, Talcum as diluents and microcrystalline cellulose as diluents. Obtained mixture was subjected for wet granulation. Water was added and mixed thoroughly to form dough mass. The mass was passed through mesh no. 12 to obtain wet granulation. The wet granules were dried at 60° C for 4 hours. Dried granules were passed through mesh no. 16 to break aggregates. Lubricants talcum and magnesium stearates were passed through mesh no. 100 on to dry granules and blended in a closed polyethylene bag. The tablet granules were compressed by using 16 station tablet compression machine (electrical Motor-Crompton Greaves and A.C. Drives-Siemens) to a hardness of 5-6 kg/cm2 using 9 mm flat punches. In each case 500 tablets were compressed. Prepared tablets were collected in a poly bag.
Results: Evaluation of developed formulation for various pre-compression and post-compression parameters was found to be within pharmacopoeial limits.
Pre-compression parameters of the formulation- Pre-compression parameters were characterized on the basis of their physical parameters. Bulk density (0.338 g/ml), Tapped density (0.458 g/ml), Compressibility ratio (23.89 %), Hausner's ratio (1.38).
Post-compression parameters: Weight variation, hardness and friability pass U.S.P. specification. Tablets of all formulation showed good physical appearance, disintegration test indicated that the tablets of all formulation were dissolved in desire time. Disintegration time of all the formulation have to be less than 45 minute. Disintegration time of the various formulation were found in following order in min F5 (8.10±0.39)>F6 (8.15±0.42)>F3 (8.33±0.43)> F2 (8.35±0.46)> F4 (8.37±0.47)> F1 (8.40±0.43).
This is due to F5 and F6 contain maximum concentration of superdisintegrants (CCS-8.5%, SSG-9.2%), than followed by other formulation. Weight variation tests, hardness and friability test indicated that, tablets of all formulation were having good compactness and mechanical strength and passes U.S.P. specification.
In-vitro dissolution studies revealed that the release rate of Efavirenz coated tablets were found to be in following order F6>F5>F4>F3>F2>F1. This is due to F6 contain maximum concentration of superdisintegrants concentration.