Asian Journal of Research in Pharmaceutical Sciences

V. Jhansipriya Marabathuni ¹, P. Dinesh ¹, R. Ravikumar ¹, P. Yamini ¹, P. Sai Kiran ¹, P. Hussain ¹, M. M. Prasada Rao ²

Affiliations
1 Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili, IN
2 Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole, IN

Abstract

The buccal region of the oral cavity is an attractive target for administration of the drug of choice. Sustained release formulations have been developed and are gaining in popularity and medical acceptance. To increase bioavailability and prevent first pass metabolism of drug, Amlodipine besylate was embedded in sustained released buccal patch over period of 6 hour. The objective of present work was to characterize the effect of chitosan with PVP K-30 on water soluble drug by preparing mucoadhesive buccal patch. Each formulated batch was subjected to various evaluation parameters. The swelling percentage was found to be function of solubility of drug and PVP K-30. The mucoadhesive strength, vapour transmission and in-vitro released of water soluble drug through water insoluble chitosan base matrix were found satisfactorily. The AMB shows some suitability with those polymers.

Keywords

Buccal Patch, Sustained Drug Delivery, Bioadhesion, Mucoadhesive Buccal Delivery.

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Konda Ravi Kumar ¹, K. N. S. Karthik ¹, P. Reshma Begum ¹, M. M. Prasada Rao ²

Affiliations
1 Department of Pharmaceutical Chemistry, Hindu College of Pharmacy, Amaravathi Road, Guntur, IN
2 Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole-523272, IN

Abstract

Five series of benzothiazole moieties were efficiently synthesized and evaluated for antimicrobial and anticancer activities. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed higher activity against fungi than bacteria. Compounds BT-02 exhibited the greatest antimicrobial activity. Preliminary study of the structure-activity relationship revealed that electronic factors in benzothiazole rings had a great effect on the antimicrobial activity of these compounds. The analgesic activity of compounds performed by using tail immersion method. in this case, compound BT-02 shows activity at 100 mg/kg dose 46 ± 0.22, 51 ± 0.22,58 ± 0.43, 48 ± 0.27 at time interval of 30 min,1 hour,2 hour,3 hour respectively compare with the other compounds due to the greater electronic effects.

Keywords

Benzthiazole, Anti Microbial Activity, Tail Immersion Method.

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