Asian Journal of Research in Pharmaceutical Sciences

Manukonda Keerthi ¹, J. Lakshmi Prasanna ¹, K. Santho Sharuna ¹, N. Rama Rao ¹

Affiliations
1 Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P., IN

Abstract

Encase of all pharmaceutical products, with a clear information i.e;label about the information of drug nature, quantity manufacturing date and expiry date, with a clear information on storage of drugs. Single label shows whole information about drug. Packaging gives more information for a layman people about the use of drug.Nowdays packaging development is more important along with the drugsafety.packaging should be firm and safe up to the enduser of product. Packaging means a blends of science and technology. Packaging area not only helps in creation of wealth, preserving product quality, but also lengthens the shelf life of products. Growing demand of packaging in the pharmaceutical companies there is a demand for packaging professionals for producing consistent qualitative packaging materials in optimum cost. This review provides a brief introduction about packaging functions and packaging materials for different formulations like solid dosage forms, semisolid dosage forms, oral liquids, parenteral, liposome and transdermal patches.

Keywords

Packaging, Tamper Resistant Packaging, Liposome's, Suppositories, Packaging Materials.

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Keerthi Manukonda ¹, N. Rama Rao ¹, M. Santhosh Aruna ¹, J. Lakshmi Prasanna ¹

Affiliations
1 Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P, IN

Abstract

Solid dispersions are one of the techniques to improve the solubility of the poorly soluble drugs. In this technique a poorly soluble drug is dispersed in the highly soluble hydrophilic matrix, two types of polymers are considered as carriers i.e., lactose, dextrose and cornstarch. Solubility is the basic step for formulation of different type of dosage forms. clopidogrel bisulphate is a BCS class II drug having low solubility and high permeability, used as ant platelet drug to inhibit blood clots in coronary artery disease, peripheral vascular disease and cerebrovascular disease. In this research article Clopidogrel bisulphate solubility has been increased by co-grinding method i.e.,one of the solid dispersion technique lactose (1:5,1:10,1:15), dextrose (1:10,1:15) cornstarch:lactose (1:10,1:15) from three different polymers cornstarch: lactose showed 99%solubility than dextrose and lactose. In-vitro dissolution studies were conducted in P^H 6.8 buffer.

Keywords

Clopidogrel Bisulphate, Solid Dispersions, Antiplatelet, Cornstarch, Lactose.

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J. Lakshmi Prasanna ¹, B. Deepthi ¹, N. Rama Rao ¹

Affiliations
1 Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034, IN

Abstract

Rectal drug delivery is an efficient alternate to oral and parenteral route of administration in partial avoidance of first pass metabolism and protein peptide drug delivery. This route allows both local and systemic therapy of drugs. Controlled absorption enhancement of drugs can be achieved by the rectal route because of the constant conditions in the rectal environment. In the present review various absorption enhancers with their mechanism of action in improving drug absorption through rectal epithelium and the potential of rectal route in delivering protein and peptides, analgesics and antiepileptics are discussed. This review also presents affects of various absorption promoting adjuvant on the rectal absorption of drugs.

Keywords

Rectal Absorption, Enamine Derivatives, Salicylates, Fatty Acids, Cyclodextrins, Protease Inhibitors.

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