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Saha, Dibyajyoti
- Pharmacognostic Studies of Aerial Part of Methanolic Extract of Plumbago indica L
Abstract Views :397 |
PDF Views:4
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
2 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
2 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 3 (2012), Pagination: 88-90Abstract
The aerial part of Plumbago indica L. (family: Plumbaginaceae) was studied to fix the parameters for pharmacognostical standards. The results of organoleptic study offer a scientific basis for the use of Plumbago indica L. which possess characters like green colour, characteristic odour, mucilaginous and slightly bitter taste. The fluorescence analysis under visible UV light and under UV light by treatment with different chemical reagents showed different colour changes. These created an interest to test the possible phytochemical activity of the plant. In the screening process of Plumbago indica L. indicate the presence of Reducing sugars , Alkaloids, Steroids, Flavonoids and Gums. The Pharmacognostic study was performed by using standard procedure. Further, detailed studies are needed to know whether in-vivo administration of the extracts is beneficial for patients.Keywords
Organoleptic, Fluorescence, Pharmacognostic Study.
References
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- Dubey, N.K., Kumar, R. and Tripathi, P. (2004): Global promotion of herbal medicine: India's opportunity, Current Science, 86(1), pp.37-41.
- Gaikwadi, S.S., Vadlamudi, V.P., Waghmaee, S.P., Maral, V.J., Ranteke, V.D. and Dhok, A.P. (2003): Phytochemical analysis of aqueous extract of few medicinal plants, PKV. Res. J., 27(1), pp.91-92.
- Van Der Vijver Lm. Distribution of plumbagin in the Plumbaginaceae. Phytochemistry 1974, Vol 11, Pages 3247- 3248.
- Bala Rathinasabapathi, Walid M. Fouad, and Celia A. Sigua . β- Alanine Betaine Synthesis in the Plumbaginaceae. Purification and Characterization of a Trifunctional, S-Adenosyl-l- Methionine-Dependent N-Methyltransferase from Limonium latifolium Leaves. Plant Physiol. 2001, Vol 126(3), Pages 1241- 1249.
- Jackson, B.P. and Snowdown, D.W. (1968): Powdered vegetable drugs, Cheer Chil Ltd., London, pp.25.
- Kokoshi, G.J., Kokoshi, J.R. and Sharma, F.J. (1958): Fluorescence of powdered vegetable drugs under ultra violet radiation, J. Amer. Pharm. Assn., 38(10), pp.715-717.
- Chase, C.R. and Pratt, R.F. (1949): Fluorescence of powdered vegetable drugs with particular reference to the development of systems of identification, J. American Pharm. Assoc., 38, pp.324- 333.
- Pandey, H.C., Dixit, R.S. and Sharma, H.P. (1984): Addition to the Pharmacognosy of Kalimulri (Curculigo orchioides), Bull. Med. Ethnobot. Res., 5(1-2), pp. 55-56.
- Evaluation of Antimotility Effect of Plumbago indica (L.) on Charcoal Induced Gastrointestinal Motility in Mice
Abstract Views :396 |
PDF Views:5
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University Bangladesh Chittagong, BD
1 Department of Pharmacy, BGC Trust University Bangladesh Chittagong, BD
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 3 (2012), Pagination: 95-97Abstract
Evaluation of antimotility activity was done in intestine of mice treated with methanolic extract of Plumbago indica L. (MEPI).Charcoal was used as a promotility agent. The antimotility activity with the mean defecation period 302.2 and 376.4min at the dose of 250 and 500mg/kg body weight.Keywords
Plumbago indica L., Gastrointestinal Motility, Chacoal.References
- Massee B, McGahey C: A Framework for Action; Child Diarrhea Prevention. Global healthlink, a publication of the Global Health Council, www.globalhealth.org 2001., (111):
- Harrison TR: Diarrhea and Constipation. In Principles of internal medicine. 16th edition. New York: Macgraw Hill; 2005:224-232.
- Hardman JG, Limbird LE: Goodman's and Gilman's: Drugs affecting gastrointestinal function. In The pharmacological basis of therapeutics. 10th edition. New York: Macgraw Hill; 2001:1023-1024.
- Chitme HR, Chandra R, Kaushik S: Studies on anti-diarrhoeal activity of Calotropis gigantea R.Br. in experimental animals. J Pharm Pharmaceut Sci 2004, 7:70-75.
- Van Der Vijver Lm. Distribution of plumbagin in the Plumbaginaceae. Phytochemistry 1974, Vol 11, Pages 3247-3248.
- Bala Rathinasabapathi, Walid M. Fouad, and Celia A. Sigua . β-Alanine Betaine Synthesis in the Plumbaginaceae. Purification and Characterization of a Trifunctional, S-Adenosyl-l-Methionine-Dependent N-Methyltransferase from Limonium latifolium Leaves. Plant Physiol. 2001, Vol 126(3), Pages 1241-1249.
- Herida Regina Nunes Marona and Maria Beatriz Bastos LUCCHESI , (2004) , Protocol ofr Refine Intestinal Motility in mice and rats, 38: 257-260.
- Cytotoxic Activity of Ethanol Extract of Leea indica Leaf
Abstract Views :329 |
PDF Views:3
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 4 (2012), Pagination: 137-139Abstract
The cytotoxic activity of ethanol extract of Leea indica (Burm. f.) Merr., (Family: Leeaceae) leaf has been investigated in the present study. The cytotoxic activity of the L. indica ethanol extract was assessed by brine shrimp lethality bioassay method. In brine shrimp lethality bioassay LC50 value of L. indica ethanol extract was found 2.4771μg/ml with 95% confidence limit where the lower and upper limits were 2.2561 and 2.6981 μg/ml respectively, which indicates that the leaf extract has promising cytotoxic effect. The present study demonstrates that ethanol extract of L. indica leaf has significant cytotoxic effect.Keywords
Leea indica, Cytotoxic, Brine Shrimp Lethality Bioassay, LC50.- In Vitro Screening of Antifungal Activity of Methanol Extract of Plumbago indica L. against some Pathogenic Species of Fungi
Abstract Views :286 |
PDF Views:3
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 2 (2012), Pagination: 55-57Abstract
The main objective of the present study was to determine the methanolic extract of Plumbago indica L. for antifungal activity. To determine the antifungal activity, agar disc diffusion method was used. The antifungal activity of the extracts was compared with standard drug Fluconazole (500 μg/disc). The methanol extract of Plumbago indica L. showed very good antifungal activity ranging from zone of inhibition (10.0-27.0) mm and Candida albicans was the most susceptible fungal strain of the methanolic extract of. Plumbago indica L .Due to these promising results, further in vivo studies over Plumbago indica L. must be conducted.Keywords
Plumbago indica L., Methanol Extract, Antifungal Activity.- Analgesic Activity of Methanol Extract of Alpinia conchigera Griff by Acetic Acid Induced Writhing Method
Abstract Views :322 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 2 (2012), Pagination: 62-65Abstract
The present study was designed to investigate Analgesic activity of methanolic extract of Alpinia conchigera Griff, using Acetic Acid Induced Writhing method. Methanolic extract was administered intraperitoneally at doses of 250 mg/kg and 500 mg/kg to Young Swiss-albino mice. Methanol Extract of Alpinia conchigera Griff showed significant inhibition in pain response induced by thermal and mechanical stimuli in dose dependent manner. The obtained results provide promising baseline information for the potential use of these crude extract in the treatment of pain.Keywords
Alpinia conchigera Griff, Analgesic, Acetic Acid, Writhing Method.- An Ontological Design: Two Stage Mouse Skin Carcinogenesis Induced By DMBA and Promoted By Croton Oil
Abstract Views :333 |
PDF Views:0
Authors
Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, (C.G), IN
2 Dept. of Chemistry, Dr. C. V. Raman University, Kargi Road, Kota, Bilaspur, C.G.- 495113, IN
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, (C.G), IN
2 Dept. of Chemistry, Dr. C. V. Raman University, Kargi Road, Kota, Bilaspur, C.G.- 495113, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 1 (2012), Pagination: 1-3Abstract
DMBA is a polycyclic aromatic hydrocarbon which may be used as cancer initiator and croton oil is used as cancer promoter in murine skin which composed of phorbol esters. Formation of stable DMBA-DNA adduct can lead to the induction of mutation that activate proto-oncogen or inactivate tumor suppressor genes as an important event during tumor initiation. In mouse skin the promotion process like increased cell proliferation, suppression of apoatosis and induction of the production of ROS and RNS that cause increase membrane lipid peroxidation and decrease cellular antioxidant stores. ROS plays an important role in the process of mutagenesis and carcinogenesis specially tumor promotion. The main aim and rationally of this ontological design is very potent for screening of new cancer chemopreventive agents as well as anticancer drug development.Keywords
Carcinogenesis, Polycyclic Aromatic Hydrocarbon, DMBA, Croton Oil.- Xenobiotics, Oxidative Stress, Free Radicals Vs. Antioxidants: Dance Of Death to Heaven's Life
Abstract Views :384 |
PDF Views:1
Authors
Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, C.G, IN
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, C.G, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 1, No 2 (2011), Pagination: 36-38Abstract
A xenobiotic is a compound that is foreign to the body. Xenobiotics can produce a variety of biological effects, including pharmacologic responses, toxicity, genes, immunologic reactions and cancer. Oxidative stress is a leading cause to damage cells by oxidation. The rate at which oxidative damage is induced (input) and the rate at which it is efficiently repaired and removed (output). A free radical is an atom or molecule that has one or more unpaired electron(s). These are highly reactive species capable of wide spread, indiscriminate oxidation and peroxidation of proteins, lipids and DNA which can lead to significant cellular damage and even tissue and/or organ failure. Antioxidants are molecules that slow or prevent the oxidation other chemicals. Oxidation reactions can involve the production of free radicals which can form dangerous chain reactions. Antioxidants can terminate these chain reactions by removing radical intermediates and can inhibit other oxidation reactions by being oxidized themselves. Antioxidants are often reducing agents such as thiols or phenols. Therefore, we need antioxidants to ensure our defence mechanism for neutralizing harmful radicals.Keywords
Xenobiotics, Oxidative Stress, Free Radicals, Antioxidants, Polyphenolic Compounds.- Radiopharmaceuticals and Radio Opaque Contrast Media: Practice, Prospects and Potentials
Abstract Views :312 |
PDF Views:0
Authors
Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur- 495004, C.G, IN
2 Dept. of Chemistry, Dr.C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G, IN
3 Dept. of Pharmacy, Bharat Technology, Uluberia-711316, W.B, IN
4 Dept. of Pharmacy, Annamalai University, Annamalai Nagar, IN
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur- 495004, C.G, IN
2 Dept. of Chemistry, Dr.C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G, IN
3 Dept. of Pharmacy, Bharat Technology, Uluberia-711316, W.B, IN
4 Dept. of Pharmacy, Annamalai University, Annamalai Nagar, IN