Asian Journal of Research in Pharmaceutical Sciences

D. M. Shinkar ¹, Aarif S. Khatik ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjineri, Nashik, IN

Abstract

Liquisolid system is a novel concept of drug delivery via oral route. Solubility is the phenomenon of dissolution of solid in liquid phase and is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response. Poorly water soluble compound’s oral administration often require high doses in order to reach therapeutic plasma concentrations because insufficient dissolution rate of the drug is the limiting factor in the oral bioavailability and one of the most challenging aspects of drug development. Design of this technique was according to new mathematical model proposed by Spireas et al. The drug is dissolved or dispersed in suitable non-volatile solvent and this liquid medication is converted to free flow powder by using carrier and coating material. To this suitable excipients were added and tabletting by direct compression. In this case, even though the drug is in a solid dosage form, it is held within the powder substrate in solution or, in a solubilized, almost molecularly dispersed state, which contributes to the enhanced drug dissolution properties. Large scale production of fabricated drug on commercial level. Succesful liquisolid tablet is a determination of optimal flowable liquid retention.

Keywords

Liquisolid System, Dissolution of Solid.

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D. M. Shinkar ¹, Bhushan S. Bhamare ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN

Abstract

The drug delivery technology landscape has become highly competitive and rapidly evolving. More and more developments in delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. Peptides, proteins and DNA-based therapeutics cannot be effectively delivered by conventional means. To control the delivery rate of active agents to a predetermined site in human body has been one of the biggest challenges faced by drug industry. Controlled release of drugs onto the epidermis with assurance that the drug remains primarily localized and does not enter the systemic circulation in significant amounts is an area of research that is successively done by the Microsponge delivery system. This review covers the advantages of Microsponges, their formulation and applications in pharmaceutical field.

Keywords

Microsponge, Controlled Release, Topical Drug Delivery, Oral Drug Delivery, Liquid-Liquid Suspension Polymerization.

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D. M. Shinkar ¹, Rohan S. Gadakh ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN

Abstract

Disintegrants are the substances that causes the rapid disintegration of the capsules or tablets into smaller particles that dissolves more rapidly than in the absence of the disintegrants. On the other hand superdisintegrants, are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhances drug dissolution rate. Superdisintegrants categories such as synthetic, semi-synthetic, natural and coprocessed blends etc. They are used in mouth dissolving tablet as well as conventional tablet to overcome the limitations of this dosage form. Superdisintegrants are generally used at a low conc. in the solid dosage form. The present review comprises the various kinds of Superdisintegrants like natural and synthetic which are being used in the formulation.

Keywords

Superdisintegrants, Disintegrants, Fast Release, Swelling, Wetting.

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