Asian Journal of Research in Pharmaceutical Sciences

S. B. Patil ¹, M. Y. Lende ¹, V. S. Thakur ¹, N. S. Naikwade ¹, C. S. Magdum ², G. M. Chavan ³

Affiliations
1 Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivaji nagar, Sangli ,Maharashtra – 416 416, IN
2 Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, IN
3 P.S.G.V.P. Mandal's College of Pharmacy, Shahada, Maharashtra, IN

Abstract

Sunscreen resources mostly obtained from plants in form of natural substances which are ability to absorb ultraviolet ray in the UVA region. This paper evaluates UV absorption ability of flowers from various varieties of Clitoria ternata Linn (Fabaceae), Canna indica Linn (Scitaminaceae), as an anti-solar agent. Extracts were prepared by maceration with a mixture of distilled water and methanol (1:1). The method is performed by UV spectrophotometer in the range of 200 to 400 nm and results of all the extracts shows effective UV absorption in the given range.

Keywords

UV Protection, Clitoria ternata Linn, Canna indica Linn, Hydro-Alcoholic Extract.

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Rohan R. Vakhariya ¹, Swati S. Talokar ¹, V. R. Salunkhe ¹, C. S. Magdum ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, IN

Abstract

The present research work support preformulation, formulation, development and optimization of solid lipid nanoparticles containing simvastatin as an antihyperlipidemic drug. The different batches of formulation were obtained using simvastatin as active pharmaceutical ingredient, stearic acid as the source of lipid and β - cyclodextrin as a polymer. Solid lipid nanoparticles of simvastatin were prepared by precipitation method. The prepared formulations were evaluated for various parameters like Particle size, Percentage entrapment efficiency, Measurement of Zeta Potential, FTIR, in-vitro release study. The result was found to be within standard limit. FTIR study reports indicated that there was no interaction between Simvastatin and other excipients. Motic microscope shown that the nanoparticles size ranges from 100-550nm. Percent entrapment efficiency was between 61.40% - 92.30%. Based on the resultants of the entrapment and particle size of nanoparticles, formulation S6 was observed to be optimized formulation. The optimized formulation exhibited 63.75% cumulative drug release after 24 h. The optimized batch shows mean of zeta potential at -44.0 mV.

Keywords

Antihyperlipidemic Drug, β–Cyclodextrin, Entrapment Efficiency, Zeta Potential, Motic Microscope.

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