Asian Journal of Research in Chemistry

V. I. Patel ¹, R. G. Patel ¹, N. G. Patel ¹, S. R. Panchal ¹, P. D. Bhardia ¹

Affiliations
1 Dep. of Pharmaceutical and Medicinal Chemistry, B.S. Patel Pharmacy College, Linch, Mehsana, Gujarat, IN

Abstract

Some New 2-Imino-3-[Carboxamido o-hydroxy Phenyl]-5-Arylidene-4-Thiazolidinone, unsubstituted or carrying hydroxy, nitro and chloro groups on the benzene ring, were synthesized and assayed in vitro for their antibacterial activity against Gram positive and Gram negative bacteria by the cup-plate method . The 5-arylidene derivatives showed an antibacterial efficacy considerably greater than that of the parent 2-imino-3-(carboxamido p-hydroxyphenyl)-thiazolidine-4-one, suggesting that the substituted and unsubstituted 5-arylidene moiety plays an important role in enhancing the antibacterial properties of this class of compounds. All the title compounds characterised on the basis of their IR, MASS, ¹H NMR spectroscopic data analysis. The synthesized compounds were screened for their in vitro antibacterial activity against Staphylococcus aureus, B. citrus, Escherichia coli, by measuring the zone of inhibition in mm. The antibacterial activity was performed by cup plate method at concentration 20 μg/ml and 50 μg/ml and reported. Nutrient agar was employed as culture medium and DMF was used as solvent control. Streptomycin used as standard for antibacterial activity. From the antibacterial screening it was observed that all the compounds exhibited activity against all the organisms employed. Compound bearing -2ClC₆H₄, -4ClC₆H₄ substituents shows better anti bacterial activity than other compounds.

Keywords

2-Imino-3-(Carboxamido O-Hydroxyphenyl)-Thiazolidine-4-One, Thiazolidinone Derivatives, Antibacterial Activity.

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