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Pandeya, S. N.
- Various Methods for Synthesis of Purine Analogues
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Authors
Affiliations
1 Department of Pharmaceutical Sciences, Saroj Institute of Technology and Management, Lucknow, IN
1 Department of Pharmaceutical Sciences, Saroj Institute of Technology and Management, Lucknow, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 9 (2011), Pagination: 1361-1365Abstract
The purine analogues are new class of nonclassical antimicrobial agents that binds with riboswitches. Purine (adenine) analogues are having antimicrobial, antifungal, antitumour, antiproliferative, antiviral and activity against HSV-1. Riboswitches are structured RNA domains that can bind directly to specific ligands and regulate gene expression. These RNA elements are located most commonly within the non-coding regions of bacterial mRNAs, because these genes were involved in fundamental metabolic pathways in certain bacterial pathogens. Purine-binding riboswitches may be targets for the development of novel antimicrobial agents. Designed compounds are bound by a purine riboswitches aptamer in vitro with affinities comparable to that of the natural ligand, and several also inhibit microbial growth.Keywords
Purines, Synthesis.- Various Approaches for Synthesis of 1, 5 -Benzodiazepines
Abstract Views :219 |
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Authors
S. N. Pandeya
1,
Neha Rajput
1
Affiliations
1 Department of Pharmaceutical Sciences, Saroj Institute of Technology & Management, Sultanpur Road, Lucknow-226002 (U.P.), IN
1 Department of Pharmaceutical Sciences, Saroj Institute of Technology & Management, Sultanpur Road, Lucknow-226002 (U.P.), IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 6 (2011), Pagination: 863-872Abstract
Benzodiazepines and its derivatives constitute an important class of heterocyclic compounds which possess a wide range of therapeutic and pharmacological properties. This manuscript includes efficient synthesis of various derivatives of 1,5-benzodiazepines by different methods.Keywords
1,5-Benzodiazepines, Heterocyclic, Pharmacological Properties.- Chemistry of Fullerene and it’s Application:A Review
Abstract Views :198 |
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Authors
Affiliations
1 Saroj Institute of Technology and Management, Lucknow, U.P., IN
2 Pranveer Singh Institute of Technology, Kanpur, U.P., IN
1 Saroj Institute of Technology and Management, Lucknow, U.P., IN
2 Pranveer Singh Institute of Technology, Kanpur, U.P., IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 234-242Abstract
The discovery of fullerenes has opened a new chapter on the physics and chemistry of carbon. So far, the physical and chemical properties of fullerenes are still under investigation. More research is needed to be done to confirm the suitability of some important application. Some potential applications will need more time for them to become reality. Their unique carbon cage structure coupled with immense scope for derivatization makes fullerenes a potential therapeutic agent. Henceforth chemistry and various potential therapeutic applications of fullerenes have been reviewed in the present paper. These include anti HIV-protease activity, photodynamic DNA cleavage, free radical scavenger, antimicrobial action and use of fullerenes as diagnostic agents.Keywords
Fullerenes, Anti-HIV Agent, Antibacterial Agent, DNA Photo Cleavage, Anti-Oxidant.- Synthesis and Biological Activity of N-(1-Alkyl-4-Phenyl-6-Thioxo-1, 6-Dihydro-1, 3, 5-Triazine-2-Yl)-N-Arylidine Hydrazine
Abstract Views :153 |
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Authors
Affiliations
1 Saroj Institute of Tech. and Management, Lucknow-226002, IN
2 Harish Chandra P.G. College, Varanasi, IN
1 Saroj Institute of Tech. and Management, Lucknow-226002, IN
2 Harish Chandra P.G. College, Varanasi, IN