Asian Journal of Research in Chemistry

Sachan Dinesh ¹, S. N. Pandeya ¹, A. K. Pathak ¹

Affiliations
1 Department of Pharmaceutical Sciences, Saroj Institute of Technology and Management, Lucknow, IN

Abstract

The purine analogues are new class of nonclassical antimicrobial agents that binds with riboswitches. Purine (adenine) analogues are having antimicrobial, antifungal, antitumour, antiproliferative, antiviral and activity against HSV-1. Riboswitches are structured RNA domains that can bind directly to specific ligands and regulate gene expression. These RNA elements are located most commonly within the non-coding regions of bacterial mRNAs, because these genes were involved in fundamental metabolic pathways in certain bacterial pathogens. Purine-binding riboswitches may be targets for the development of novel antimicrobial agents. Designed compounds are bound by a purine riboswitches aptamer in vitro with affinities comparable to that of the natural ligand, and several also inhibit microbial growth.

Keywords

Purines, Synthesis.

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S. N. Pandeya ¹, Neha Rajput ¹

Affiliations
1 Department of Pharmaceutical Sciences, Saroj Institute of Technology & Management, Sultanpur Road, Lucknow-226002 (U.P.), IN

Abstract

Benzodiazepines and its derivatives constitute an important class of heterocyclic compounds which possess a wide range of therapeutic and pharmacological properties. This manuscript includes efficient synthesis of various derivatives of 1,5-benzodiazepines by different methods.

Keywords

1,5-Benzodiazepines, Heterocyclic, Pharmacological Properties.

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S. N. Pandeya ¹, Neelottama Maurya ¹, A. K. Pathak ¹, Swatantra K. S. Kushwaha ²

Affiliations
1 Saroj Institute of Technology and Management, Lucknow, U.P., IN
2 Pranveer Singh Institute of Technology, Kanpur, U.P., IN

Abstract

The discovery of fullerenes has opened a new chapter on the physics and chemistry of carbon. So far, the physical and chemical properties of fullerenes are still under investigation. More research is needed to be done to confirm the suitability of some important application. Some potential applications will need more time for them to become reality. Their unique carbon cage structure coupled with immense scope for derivatization makes fullerenes a potential therapeutic agent. Henceforth chemistry and various potential therapeutic applications of fullerenes have been reviewed in the present paper. These include anti HIV-protease activity, photodynamic DNA cleavage, free radical scavenger, antimicrobial action and use of fullerenes as diagnostic agents.

Keywords

Fullerenes, Anti-HIV Agent, Antibacterial Agent, DNA Photo Cleavage, Anti-Oxidant.

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S. N. Pandeya ¹, Vaishali Mishra ², Alka Pandey ², Ritu Srivastava ²

Affiliations
1 Saroj Institute of Tech. and Management, Lucknow-226002, IN
2 Harish Chandra P.G. College, Varanasi, IN

Abstract

Triazine, arylidinehydrazones were synthesized starting from benzoyl isothiocyanate were condensed with S-benzyl isothiourea which were further reacted with hydrazine to give s-triazynyl hydrazines. These were further reacted with different aromatic aldehydes to give the corresponding hydrazones. The structures of the compounds were confirmed by elemental analysis and spectral studies. In-vitro antibacterial testing was done by serial dilution method.

Keywords

1, 3, 5 Triazine, Hydrazines, Antibacterial.

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