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Authors
Affiliations
1 Government College of Pharmacy, Vidyanagar, Tal. Karad-415124, Dist. Satara, Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 404-406
Abstract
A new, simple, rapid and novel reproducible UV-spectrophotometer estimation method has been developed for estimation of griseofulvin in marketed formulation. The proposed method was successfully applied for the estimation of griseofulvin in commercial pharmaceutical preparation with Absorbance maxima at 263.5 nm. A Shimadzu 1700 UV-Visible spectrophotometer with 1 cm matched quartz cells and acetone:ethanol:0.1N HCl (1:1:8) solvents were employed in the method. Developed methods obeyed the Beer’s law in the concentration range of 0.5-3.5 μg/ml and methods were validated statistically. The SD and Percentage recovery of the drug for the proposed method are given in method indicating no interference of the tablet excipients. The results of the tablet analysis were validated with respect to accuracy (recovery), linearity, limit of detection and limit of quantitation were found to be satisfactory.
Keywords
Absorbance Maxima, Area Under Curve (AUC), Griseofulvin, UV Spectrophotometer.
