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Rajan V, Rele
- A Validated Potentiometric Titration Method for Quantitative Determination of Favipiravir from Pharmaceutical Preparation
Abstract Views :73 |
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Authors
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1 Central Research Laboratory D.G. Ruparel College Mahim, Mumbai 400 016., IN
1 Central Research Laboratory D.G. Ruparel College Mahim, Mumbai 400 016., IN
Source
Asian Journal of Research in Chemistry, Vol 15, No 1 (2022), Pagination: 49 - 51Abstract
A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of favipiravir from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 10 % to 50 % w/v of 0.200 mg of drug substance weight. The percentage recovery of favipiravir in the optimized method was between 99.65 to 100.08 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.Keywords
Favipiravir, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid.References
- Sohrabi, C., Alsafi, Z.; O’Neill, N.; Khan, M.; Kerwan, A.; AlJabir, A.;et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19), Int. J. Surg., 76;2020:, 71–76.
- Zhu, R. F.; Gao, R. I.; Robert, S. H.; Gao, J. P.; Yang, S. G.; Zhu, C.Systematic review of the registered clinical trials of coronavirus diseases 2019 (COVID-19), J. Transl. Med. 18;2020: 274–279.
- Prajapat, M.; Sarma, P.; Shekhar, N.; Avti, P.; Sinha, S.; Kaur, H.; et al. Drug targets for corona virus: A systematic review. Indian J.Pharm. 52(1); 2020: 56–63.
- Dong, L.; Hu, S.; Gao, J. Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discov. Ther. 14(1);2020: 58–60.
- De Clercq, E. New nucleoside analogues for the treatment of hemorrhagic fever virus infections. Chem.–Asian Journal. 14(22) ; 2019: 3962–3968.
- Delang, L.; Abdelnabi, R.; Neyts, J. Favipiravir as a potential countermeasure against neglected and emerging RNA viruses.Antiviral Research. 153;2018: 85–94.
- Chen, C.; Huang, J.; Cheng, Z.; Wu, J.; Chen, S.; Zhang, Y.; et al. Favipiravir versus arbidol for COVID-19: A randomized clinical trial, medRxiv. 3; 2020: 17–20.
- Ibrahim Bulduk, HPLC-UV method for quantification of favipiravir in pharmaceutical Formulations, Acta Chromatographica 2020:1-7 DOI: 10.1556/1326.2020.00828.
- R. Suzuki, Y. Osaka, Quantitative Analysis of Favipiravir Spiked in Plasma Using by HPLC, Shimadzu excellence in science, application news no L 570,http://www.shimadzu.com/about/trademarks/index.html.
- China patent. A kind of Favipiravir has the HPLC assay method of related substance. 21.09.2016. (CN104914185B)
- China patent HPLC method for measuring related substances in Favipiravir. 16.09.2015. (CN104914185A).
- Rele Rajan V. Tiwatane Prathamesh P. Determination of Favipiravir from Pharmaceutical Dosage Form by Extractive Ion Pair Complex Colorimetric Method, Asian Journal of Chemistry,14(5);2021:321-323
- Determination of Molnupiravir by Extractive Colorimetric Method from Pharmaceutical Dosage Form
Abstract Views :63 |
PDF Views:0
Authors
Affiliations
1 Central Research Laboratory, D.G. Ruparel College, Mahim, Mumbai 400 016., IN
1 Central Research Laboratory, D.G. Ruparel College, Mahim, Mumbai 400 016., IN
Source
Asian Journal of Research in Chemistry, Vol 15, No 4 (2022), Pagination: 256 - 258Abstract
Simple and accurate extractive colorimetric method was developed for the estimation of molnupiravir in Pharmaceutical dosage forms. The method was based on the formation of colored ion pair complexes by the drugs with thiocynate ions. These ion pair complexes were quantitatively extracted under the experimental condition in organic solvent like chloroform. The absorbance values were measured at 620 respectively. The proposed method was validated statistically. A recovery of method was carried out by standard addition methods. The Beer’s law ranges were found to be 1-14 μg/ml, respectively. The low values of standard deviation and percentage RSD indicate high precision of method. Hence the method is useful for routine estimation of molnupiravir in tablets respectively.Keywords
Molnupiravir, Cobalt nitrate, Ammonium thiocynate, Chloroform, ethanol.References
- R.C. Group. Lopinavir-ritonavir in patients admitted to hospital with COVID-19 (Recovery): a randomized, controlled, open-label, platform trial. Lancet. 396 (10259); 2020 :1345–1352.
- Chen J, Xia L, Liu L, Xu Q, Ling Y, Huang D, Huang W, Song S, Xu S, Shen Y, Lu H. Antiviral Activity and Safety of Darunavir/Cobicistat for the Treatment of COVID-19. Open Forum Infect Dis. 7 (7; 2020; 241
- Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, Hohmann E, Chu HY, Luetkemeyer A, Kline S, Lopez de Castilla D, et al. Remdesivir for the Treatment of Covid-19 - Final Report. The New England Journal of Medicine. 383 (19); 2020; 1813–1826.
- Toots M, Yoon J-J, Cox RM, Hart M, Sticher ZM, Makhsous N, Plesker R, Barrena AH, Reddy PG, Mitchell DG, Shean RC, et al.Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci Transl Med. 11 (515); 2019; 5866.
- Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schafer A, Dinnon KH 3rd, Stevens LJ, Chappell JD, et al. An orally bioavailable broad-spectrum antiviral inhibits SARSCoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med.12 (541); 2020
- Painter GR, Bowen RA, Bluemling GR, DeBergh J, Edpuganti V, Gruddanti PR, Guthrie DB, Hager M, Kuiper DL, Lockwood MA, Mitchell DG, et al. The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection. Antiviral Res.; 171; 2019: 104597.
- Painter WP, Holman W, Bush JA, Almazedi F, Malik H, Eraut NCJE, Morin MJ, Szewczyk LJ, Painter GR. Human Safety, Tolerability, and Pharmacokinetics of a Novel Broad-Spectrum Oral Antiviral Compound, Molnupiravir, with Activity Against SARS-CoV-2.medRxiv.12.10; 2020:.20235747.
- Amara et al. J Pharm Biomed Anal. 2021 9.
- Rosenke K, Hansen F, Schwarz B, Feldmann F, Haddock E, Rosenke R, Meade-White K, Okumura A, Leventhal S, Hawman DW, Ricotta E, et al. Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian Hamster Model. Res Sq. .3; 2020:86289.
- Alieu Amaraa, Sujan Dilly Penchalaa, Laura Elsea, Colin Haleb, Richard Fitz Geraldb, Lauren Walkerb, Rebecca Lyonsb, Tom Fletcherc, Saye Khoo, The development and validation of a novel LCMS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human plasma and saliva, J Pharm Biomed Anal. 206; 2021: 114356.doi:10.1016/j.jpba.2021.11435628.
- Tuba Reçber, Selin Seda Timur, Sevilay Erdogan Kablan, Fatma Yalçın, Tutku Ceren Karabulut, R. Neslihan Gürsoy, Hakan Eroglu, Sedef Kır, A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies, Journal of Pharmaceutical and Biomedical Analysis, 214; (2022): 114693
- Rajan V. Rele, S.S. Zarapker Vipul Doshi,V.M. Shah, A simple extractive colorimetric determination of three drug from pharmaceutical preparations., Indian Drug. 24(12); 1987:560-564.
- Rajan V. Rele, Pankaj Gurav. A simple extractive spectrophotometric determination of loradatadine desloratadine and rupatadine from pharmaceutical formulation, International Journal of Pharma and
- Biosciences. 3(2); 2012:89-92.
- Rele Rajan V. Tiwatane Prathamesh P. Determination of Favipiravir from Pharmaceutical Dosage Form by Extractive Ion Pair Complex Colorimetric Method, Asian J. Research Chem.,14(5); 2021:321-323.
- DOI: 10.52711/0974-4150.2021.00054.
- Simple Extractive Spectrophotometric Method for Determination of Favipiravir from Pharmaceutical Formulation
Abstract Views :65 |
PDF Views:0
Authors
Affiliations
1 Central Research Laboratory, D. G. Ruparel College, Mahim, Mumbai - 400 016 ., IN
2 Central Research Laboratory, D. G. Ruparel College, Mahim, Mumbai - 400 016., IN
1 Central Research Laboratory, D. G. Ruparel College, Mahim, Mumbai - 400 016 ., IN
2 Central Research Laboratory, D. G. Ruparel College, Mahim, Mumbai - 400 016., IN
Source
Asian Journal of Research in Chemistry, Vol 15, No 4 (2022), Pagination: 299 - 302Abstract
Simple sensitive and accurate extractive spectrophotometric methods have developed for the estimation of favipiravir in pharmaceutical dosage form. The methods are based on the formation of coloured complexes by the drug with reagents like bromophenol blue, solochrome dark blue and bromocresol green in acidic medium. The ion associated complexes were formed and quantitatively extracted under the experimental condition in chloroform. The absorbance values were measured at 420nm, 495nm and 430nm respectively. The proposed methods were validated statistically. Recoveries of methods were carried out by standard addition methods. The linearity was found to be 1.0-12.0μg/ml, 2-20μg/ml, 1-16μg/ml for methods 1, 2 and 3 respectively. The low values of standard deviation and percentage RSD indicate high precision of methods. Hence these methods are useful for routine estimation of favipiravir in tabletsKeywords
Favipiravir, Bromophenol blue, solochrome dark blue, Bromocresol green, Chloroform ethanol.References
- Sohrabi, C., Alsafi, Z.; O’Neill, N.; Khan, M.; Kerwan, A.; AlJabir, A.;et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19), Int. J. Surg., 76;2020:, 71–76.
- Zhu, R. F.; Gao, R. I.; Robert, S. H.; Gao, J. P.; Yang, S. G.; Zhu, C. Systematic review of the registered clinical trials of coronavirus diseases 2019 (COVID-19), J. Transl. Med. 18;2020: 274–279.
- Prajapat, M.; Sarma, P.; Shekhar, N.; Avti, P.; Sinha, S.; Kaur, H.; et al. Drug targets for corona virus: A Systematic Review. Indian J. Pharm. 52(1); 2020: 56–63.
- Dong, L.; Hu, S.; Gao, J. Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discov. Ther. 14(1);2020: 58–60.
- De Clercq, E. New nucleoside analogues for the treatment of hemorrhagic fever virus infections. Chem.–Asian Journal. 14(22); 2019: 3962–3968.
- Delang, L.; Abdelnabi, R.; Neyts, J. Favipiravir as a potential countermeasure against neglected and emerging RNA viruses.Antiviral Research. 153;2018: 85–94.
- Chen, C.; Huang, J.; Cheng, Z.; Wu, J.; Chen, S.; Zhang, Y.; et al. Favipiravir versus arbidol for COVID-19: A randomized clinical trial, medRxiv. 3; 2020: 17–20.
- Ibrahim Bulduk, HPLC-UV method for quantification of favipiravir in pharmaceutical Formulations, Acta Chromatographica 2020:1-7 DOI: 10.1556/1326.2020.00828.
- R. Suzuki, Y. Osaka, Quantitative Analysis of Favipiravir Spiked in Plasma Using by HPLC, Shimadzu excellence in science, application news no L 570, http://www.shimadzu.com/about/ trademarks/index.html.
- China patent. A kind of Favipiravir has the HPLC assay method of related substance. 21.09.2016. (CN104914185B)
- China patent HPLC method for measuring related substances in Favipiravir. 16.09.2015. (CN104914185A).
- Journal.pntd.0005389 Thi Huyen Tram Nguyen and et.al. Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted. 23; 2017: https://doi.org/10.1371/journal.pntd.0005389.
- Rele Rajan V., Tiwatane Prathamesh P. Determination of Favipiravir from Pharmaceutical Dosage Form by Extractive Ion Pair Complex Colorimetric Method. Asian Journal of Research in Chemistry. 14(5),2021:321-323.
- Rele Rajan V., Tiwatane Prathamesh P. A Validated Potentiometric Titration Method for Quantitative Determination of Favipiravir from Pharmaceutical Preparation. Asian Journal of Research in Chemistry 15(1): 2022;49-51.
- Rajan V. Rele and et.al, A simple extractive colorimetric determination of three drug from pharmaceutical preparations. Indian Drugs. 24(12); 1987:560-564.
- Rajan V. Rele, Pankaj Gurav. A simple extractive spectrophotometric determination of loradatadine desloratadine and rupatadine from pharmaceutical formulation. International Journal of Pharma and Biosciences. 3(2);2012 :89-92.
- A Validated Potentiometric Titration Method for Quantitative Determination of Molnupiravir from Pharmaceutical Preparation
Abstract Views :162 |
PDF Views:0
Authors
Affiliations
1 Central Research Laboratory, D.G. Ruparel College Mahim Mumbai 400 016., IN
2 Central Research Laboratory, D.G. Ruparel College Mahim Mumbai 400 016 ., IN
1 Central Research Laboratory, D.G. Ruparel College Mahim Mumbai 400 016., IN
2 Central Research Laboratory, D.G. Ruparel College Mahim Mumbai 400 016 ., IN
Source
Asian Journal of Research in Chemistry, Vol 15, No 6 (2022), Pagination: 439 - 442Abstract
A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of molnupiravir from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 10 % to 50 % w/v of 100 mg of drug substance weight. The percentage recovery of molnupiravir in the optimized method was between 99.05 to 99.81 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.Keywords
Molnupiravir, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid.References
- R.C. Group. Lopinavir-ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomized, controlled, openlabel, platform trial. Lancet. 396 (10259); 2020 :1345–1352.
- Chen J, Xia L, Liu L, Xu Q, Ling Y, Huang D, Huang W, Song S, Xu S, Shen Y, Lu H. Antiviral Activity and Safety of Darunavir/Cobicistat for the Treatment of COVID-19. Open Forum Infect Dis. 7 (7; 2020; 241
- Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, Hohmann E, Chu HY, Luetkemeyer A, Kline S, Lopez de Castilla D, et al. Remdesivir for the Treatment of Covid-19 Final Report. The New England journal of medicine. 383 (19); 2020; 1813–1826.
- Toots M, Yoon J-J, Cox RM, Hart M, Sticher ZM, Makhsous N, Plesker R, Barrena AH, Reddy PG, Mitchell DG, Shean RC, et al. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci Transl Med. 11 (515); 2019; 5866.
- Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schafer A, Dinnon KH 3rd, Stevens LJ, Chappell JD, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med.12 (541); 2020
- Painter GR, Bowen RA, Bluemling GR, DeBergh J, Edpuganti V, Gruddanti PR, Guthrie DB, Hager M, Kuiper DL, Lockwood MA, Mitchell DG, et al. The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection. Antiviral Res.; 171; 2019: 104597.
- Painter WP, Holman W, Bush JA, Almazedi F, Malik H, Eraut NCJE, Morin MJ, Szewczyk LJ, Painter GR. Human Safety, Tolerability, and Pharmacokinetics of a Novel Broad-Spectrum Oral Antiviral Compound, Molnupiravir, with Activity Against SARS-CoV-2. medRxiv.12.10; 2020:.20235747.
- Amara et al. J Pharm Biomed Anal. 2021 9.
- Rosenke K, Hansen F, Schwarz B, Feldmann F, Haddock E, Rosenke R, Meade-White K, Okumura A, Leventhal S, Hawman DW, Ricotta E, et al. Orally delivered MK-4482 inhibits SARSCoV-2 replication in the Syrian hamster model. Res Sq. .3; 2020:86289.
- Alieu Amaraa, Sujan Dilly Penchalaa, Laura Elsea, Colin Haleb, Richard Fitz Geraldb, Lauren Walkerb, Rebecca Lyonsb, Tom Fletcherc, Saye Khoo, The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human plasma and saliva, J Pharm Biomed Anal. 206; 2021: 114356.doi:10.1016/j.jpba.2021.11435628.
- Tuba Reçber, Selin Seda Timur, Sevilay Erdo˘gan Kablan , Fatma Yalçın, Tutku Ceren Karabulut, R. Neslihan Gürsoy, Hakan Ero˘glu , Sedef Kır, A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies, Journal of
- pharmaceutical and biomedical analysis, 214; (2022): 114693.
- Rele Rajan V. Tiwatane Prathamesh P. Determination of Molnupiravir by Extractive Colorimetric Method from Pharmaceutical Dosage Form, Asian J. Research Chem. 15(4);256- 258: 2022; DOI: 10.52711/0974-4150.2022.00046
- Rele Rajan V. Tiwatane Prathamesh P. A Validated Potentiometric Titration Method for Quantitative Determination of Favipiravir from Pharmaceutical Preparation, Asian J. Research Chem.,15(1);
- :49-51. DOI: 10.52711/0974-4150.2022.00007.