Asian Journal of Research in Chemistry

Sharad Sankhe ¹, Ramesh Yamgar ², Umesh N. Pol ³

Affiliations
1 Chemistry Research Laboratory, Patkar College, Goregaon (W), Mumbai 400 062, IN
2 Chemistry Research Laboratory, Patkar College, Goregaon (W), Mumbai 400 062
3 Department of Chemistry, Willingdon College, Sangli, Maharashtra, IN

Abstract

The kinetics of oxidation of the Schiff base 2-hydroxy - 1 - Naphthalidene anil and substituted anils such as 2' - methoxy - 2 - hydroxy - 1 - naphthalidene anil, 3' - Methoxy - 2 - Hydroxy - 1 - Naphthalidene anil and 4' - Methoxy - 2 - Hydroxy - 1- Naphthalidene anil by Ce (IV) as oxidant in aqueous sulphuric acid medium. The kinetic study is carried out by using various concentrations of oxidants and the substrates, which is found to be the first order reaction. A suitable plaussible mechanism has been suggested on the basis of kinetic results.

Keywords

Kinetics of Oxidation, Schiff Base, Redox System, Reaction Mechanism.

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Udaysinha Patil ¹, Mustapha Mandewale ¹, Bapu Thorat ¹, Aarti Nagarsekar ¹, Ramesh Yamgar ²

Affiliations
1 P.G. and Research Laboratory, Department of Chemistry, Government of Maharashtra, Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East) Mumbai-400 060, IN
2 Department of Chemistry, Chikitsak Samuha’s Patkar-Varde College of Arts, Science and Commerce, Goregaon,(West), Mumbai 400 062, IN

Abstract

A series of tetrahydrosalophen Schiff bases have been prepared from the reaction of two equivalents of salicylaldehyde with one equivalent o-phenylenediamine derivatives followed by reduction with NaBH₄. The Co (II), Ni (II), Cu (II) and Zn (II) complexes of these ligands have been prepared. All the synthesized ligands and metal complexes were characterized by IR, ¹H and ¹³C-NMR, MS, XRD, TGA, UV-Visible, Fluorescence and elemental analysis. The Preliminary results of antituberculosis study showed that the salophen schiff bases 2a-2b demonstrated very good antituberculosis activity while the tetrahydrosalophen schiff bases 3a-3i showed moderate activity. Among the tested metal complexes 4a was found to be most active with minimum inhibitory concentration (MIC) of 6.25 μg/ml against Mycobacterium tuberculosis (H37 RV strain) ATCC No-27294.

Keywords

Salophen, Schiff Base, Metal Complex, Antituberculosis, Fluorescence.

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Bapu R. Thorat ¹, Bhusan Nazirkar ¹, Vaishali B. Thorat ², Kishor More ², Ravindra Jagtap ³, Ramesh Yamgar ⁴

Affiliations
1 P. G. Dept of Chemistry, Govt. of Maharashtra, Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai 400 060, IN
2 IES, Junior College, Bandra (E), Mumbai, IN
3 JJT University, Rajasthan, IN
4 Department of Chemistry, Chikitsak Samuha’s Patkar-Varde College of Arts, Science and Commerce, Goregaon (W),Mumbai 400 062, IN

Abstract

The 3-hydroxy-1-benzofuran-2-carbohydrazide was synthesized from 2-hydroxyacetophenone. To deduce the antibacterial and anticancer activity of the 3-hydroxy-1-benzofuran-2-carbohydrazide, it is docked with different biomarkers of cancer cell and bacteria. Grid was generated for each oncoproteins by specifying the active site amino acids. The binding model of best scoring analogue with each protein was assessed from their G-scores and disclosed by docking analysis using the XP visualizer tool. An analysis of the receptor-ligand interaction studies revealed that 3-hydroxy-1-benzofuran-2-carbohydrazide is most active against 3FDN (threonine protein kinase 6) and 3LAU (Arora 2 kinase) biomarkers and have the features to prove themselves as anti-tuberculosis drugs. The Cramer rules of toxicity predicts the toxicological hazard (when administered orally) from the molecular structure. It shows that it is class III toxic compound. The anti-TB studies show that it shows strong activity (1.6 μg/ml) against mycobacterium tuberculosis (H37 RV strain).

Keywords

Benzofurans, Molecular Docking, SAR Study, 3LAU, Hydrazones, TB-Activity.

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